A simple choice of IV fluid during surgery could change outcomes — which is safer?

NCT ID NCT02502773

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial tests two types of intravenous fluids given during abdominal surgery: a standard saline solution and a starch-based fluid. The goal is to see whether one leads to fewer serious complications, such as kidney problems, breathing issues, heart failure, infections, or the need for another surgery, within the first two weeks after the operation. The study includes adults at moderate-to-high risk of complications who are having abdominal surgery lasting at least two hours. By comparing these fluids in a controlled way, the trial aims to find out if the choice of fluid can improve patient safety and recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Hydroxyethyl starch (6% HES 130/0.4) compared with 0.9% saline, given as intravenous fluid during surgery
What this could lead to
If one fluid is better, it could guide safer fluid management during major abdominal surgery, potentially reducing serious complications and deaths after surgery.
What could go wrong
This is a phase 3 trial, but results may not apply to all patients or surgeries. Hydroxyethyl starch carries risks like kidney injury and bleeding, which the trial is specifically checking.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, 63003, France

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