Could a daily glass of grapefruit juice shield aging hearts and bones?
NCT ID NCT01272167
First seen Jul 31, 2026 · Last updated Aug 04, 2026 · Updated 2 times
Summary
This trial tests whether drinking grapefruit juice regularly over a long period can improve blood vessel function and bone health in healthy postmenopausal women. The study uses a crossover design, where each participant experiences both the juice and a control period, to isolate the specific role of a natural compound in grapefruit called naringin. The goal is to see if this everyday fruit juice could help prevent age-related conditions like cardiovascular disease and osteoporosis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Long-term grapefruit juice consumption, with a focus on the flavanone naringin
- What this could lead to
- If grapefruit juice's flavanones prove protective, it could point toward a simple dietary approach to support heart and bone health in postmenopausal women.
- What could go wrong
- This is a small crossover study in a specific group, so results may not apply broadly. Grapefruit juice can interact with certain medications, and the effect on bone and vascular health remains uncertain.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France
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