Please sign in to follow a disease.
A tiny molecule may shield sperm DNA from freezing damage
NCT ID NCT04011813
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This trial tests whether adding hypotaurine, a natural antioxidant, to the media used for sperm preparation and freezing can protect sperm DNA from damage. The study compares sperm samples from 33 participants, processed with or without hypotaurine, through a freeze-thaw cycle. Researchers will measure DNA integrity, chromatin packaging, and other sperm quality indicators to see if hypotaurine offers a protective effect.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- hypotaurine
- What this could lead to
- If it works, this could lead to better sperm preservation techniques, potentially improving success rates for fertility treatments using frozen sperm.
- What could go wrong
- This is a small, early-stage trial. The benefits may not be significant, and the results may not apply to all sperm samples or fertility outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CRYOPRESERVATION are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.