Could a simple infusion during surgery protect organs and save lives?
NCT ID NCT01536470
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether giving a continuous infusion of noradrenaline during high-risk surgery can prevent dangerous drops in blood pressure, compared to the standard approach of treating low blood pressure only when it occurs. The study includes 300 adults aged 50 and older undergoing major abdominal, orthopedic, or vascular surgery expected to last at least two hours. The goal is to see if this preventive strategy reduces the chance of postoperative organ failure and other serious complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- noradrenaline (also called norepinephrine), given as a continuous infusion to maintain blood pressure during surgery
- What this could lead to
- If effective, this approach could reduce organ failure after major surgery, improving recovery and reducing complications in high-risk patients.
- What could go wrong
- The trial is relatively small and focuses on a specific high-risk group, so results may not apply to all surgeries. Noradrenaline can cause high blood pressure or heart rhythm issues, and the benefit over standard care is not yet proven.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France