Could a vitamin and herb blend tame the Body's stress response?

NCT ID NCT04391452

Completed Symptom relief Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study tests whether a daily supplement containing magnesium, B vitamins, rhodiola, and L-theanine can reduce stress in adults who report feeling stressed. Participants take either the supplement or a placebo for 28 days, and researchers measure stress through questionnaires, biological samples, heart rate variability, and brain imaging in a subset. The goal is to see if this natural blend can help calm the mind and body's response to stress.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stress Resist® (dietary supplement containing magnesium, vitamins B6, B9, B12, rhodiola, and L-theanine)
What this could lead to: If effective, this supplement could offer a natural, non-prescription option to help manage everyday stress and its physical effects.
What could go wrong: The trial is relatively small and early, and supplements often show limited benefit beyond placebo. Individual responses may vary, and it's not a substitute for professional mental health care.

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Conditions

The condition(s) this trial relates to.

Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STRESS, PSYCHOLOGICAL

Contacts and locations

Locations

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

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