Could short bursts of low oxygen help heal the brain?

NCT ID NCT04890639

Completed Knowledge-focused Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Researchers monitored vital signs and symptoms to check for side effects and also looked for any improvements in memory, thinking, and motor control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acute Intermittent Hypoxia (brief low-oxygen breathing sessions)
What this could lead to: If safe and effective, this approach could point toward a new way to boost brain recovery after traumatic brain injury.
What could go wrong: This is a very small, early safety study with only 12 participants, so results may not apply widely. The treatment involves low oxygen, which could cause side effects like dizziness or shortness of breath.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Hypoxia traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN INJURIES, TRAUMATIC

Contacts and locations

Locations

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

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