Zapping resistant tumors: could targeted radiation buy more time for prostate cancer patients?
NCT ID NCT03644303
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone drugs. The goal was to see if this approach could delay the need for chemotherapy and improve cancer control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Stereotactic body radiotherapy (SBRT) plus continued hormone therapy (enzalutamide or abiraterone)
What this could lead to
If successful, this approach could offer a new way to control metastatic prostate cancer longer without needing chemotherapy.
What could go wrong
This is a mid-stage trial with 86 participants, so results may not apply to all patients. SBRT may not slow progression for everyone, and side effects from radiation are possible.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Angelie Tirona
Sutton, Surrey, SM5 3EZ, United Kingdom
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Belfast Health & Social care Trust
Belfast, Northern Ireland, BT8 8BH, United Kingdom
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Leeds Teaching Hospitals NHS Trust
Leeds, West Yorkshire, LS9 7TF, United Kingdom
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The Christie NHS Foundation Trust
Manchester, Manchester Greater, M20 4BX, United Kingdom
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The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, West Midlands, B15 2TH, United Kingdom
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Velindre Cancer Centre
Cardiff, Wales, CF14 2TL, United Kingdom