Zapping resistant tumors: could targeted radiation buy more time for prostate cancer patients?

NCT ID NCT03644303

Completed Disease control Sponsor: Royal Marsden NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone drugs. The goal was to see if this approach could delay the need for chemotherapy and improve cancer control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stereotactic body radiotherapy (SBRT) plus continued hormone therapy (enzalutamide or abiraterone)
What this could lead to: If successful, this approach could offer a new way to control metastatic prostate cancer longer without needing chemotherapy.
What could go wrong: This is a mid-stage trial with 86 participants, so results may not apply to all patients. SBRT may not slow progression for everyone, and side effects from radiation are possible.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic neoplasm metastatic prostate carcinoma Neoplasm Metastasis prostate cancer radiation injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIRCULATING TUMOUR DNA METASTASIS PROSTATE CANCER TOXICITY DUE TO RADIOTHERAPY

Contacts and locations

Locations

Angelie Tirona

Sutton, Surrey, SM5 3EZ, United Kingdom
Belfast Health & Social care Trust

Belfast, Northern Ireland, BT8 8BH, United Kingdom
Leeds Teaching Hospitals NHS Trust

Leeds, West Yorkshire, LS9 7TF, United Kingdom
The Christie NHS Foundation Trust

Manchester, Manchester Greater, M20 4BX, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
University Hospitals Birmingham NHS Foundation Trust

Birmingham, West Midlands, B15 2TH, United Kingdom
Velindre Cancer Centre

Cardiff, Wales, CF14 2TL, United Kingdom

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