Injury

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This trial tests a real-time algorithm-driven system that gives doctors feedback on ventilator settings to protect the lungs of critically ill patients. The study will include 208 adults on breathing machines with acute respiratory distress syndrome (ARDS). The goal is to see if …

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This study compares two radiotherapy schedules for men whose prostate cancer has returned after surgery. The standard treatment takes 5 weeks, while the shorter one takes 4 weeks. Researchers want to see if the shorter schedule causes no more side effects and controls the cancer …

This trial looks at two approaches for treating displaced wrist fractures in children aged 4 to 10. One group gets the standard sedated reduction (where the bone is realigned under sedation) followed by a cast. The other group gets only a cast without any realignment. The study m…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This pilot study tests a new way to make a custom pressure orthosis for burn scars using 3D scanning and printing. About 25 adults with healing hypertrophic burn scars will get the device. The main goal is to see if the manufacturing process works and the orthosis fits safely.

This study tests whether adding special wound dressings (called CAMPs) to standard care helps heal pressure ulcers (bedsores) that won't close on their own. About 2,000 adults with stage 3 or 4 pressure sores will receive weekly applications of a CAMP product plus standard care, …

This early study tests whether implanting electrodes deep in the brain (thalamus) can safely help people with long-term disorders of consciousness. Only 2 participants will be enrolled, and the main goal is to check safety and see if awareness improves using a standard behavioral…

This study is testing whether a single, high-dose radiation session works as well as multiple sessions for people whose cancer has spread to a few places (oligometastatic disease). About 600 participants will be randomly assigned to receive either one or several radiation treatme…

This study compares two common surgeries for a certain type of hip fracture in adults aged 60 and older: hip replacement (arthroplasty) versus internal fixation (using screws or pins). The goal is to see which approach helps people survive, walk independently, and spend more time…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This early study tests a new implantable sensor array, called Phantom X, that picks up muscle signals to control a bionic arm. Ten adults with below-elbow amputations will receive the implant and be followed for up to 21 weeks. The goal is to see if the device is safe and allows …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study tests a wound covering made from donated human placental tissue, called NeoThelium FT, for people with chronic open wounds that have not healed for at least 4 weeks. About 132 adults will receive either standard wound care alone or standard care plus NeoThelium FT. The…

This study is following 35 adults who have received a Tipmed revision hip prosthesis during routine care. Researchers will track how well the hip works and any complications over 24 months. The goal is to see if the device performs safely and effectively in real-world use.

This trial investigates the safest time to restart direct oral anticoagulants (DOACs) after a traumatic brain bleed. Many older adults who fall and hit their head are on blood thinners for conditions like atrial fibrillation, and stopping them raises the risk of stroke or clots. …

This study is testing a material called Neocement Inject P, used to rebuild bone in the jaw for dental implants. Researchers will follow 66 adults to see if the material is safe and helps grow enough bone for implant placement. The goal is to gather real-world evidence on how wel…

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests an implanted spinal cord stimulator (ARC-IM System) to help people with chronic spinal cord injury manage dangerously low blood pressure and fainting. Sixty participants will receive the implant and be randomly assigned to active or sham stimulation for 3 months,…

This study compares oral (pill) antibiotics to intravenous (IV) antibiotics for treating infected broken bones that haven't healed properly. About 250 adults with this condition will be randomly assigned to receive either oral or IV antibiotics for up to 6 weeks after surgery. Th…

This study tests whether using cryopreserved aortic patches (donated tissue) can safely repair defects in the windpipe or bronchial tubes. Ten people with severe tracheal narrowing or deformities will receive this surgical patch. The main goal is to see if it reduces death and co…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This early-phase trial tests a single inhaled dose of a lab-made protein (Rh-KGF-2) in 24 adults with moderate to severe ARDS who are on ventilators. The goal is to see if the drug is safe and tolerable, and to find the right dose. Participants are split into three dose groups, w…

This study tests whether injecting a person's own skin cells from the palm or sole into their amputation stump can thicken the skin and reduce breakdown. Researchers will enroll 50 adults with below-knee amputations who use a prosthetic. The goal is to see if this treatment is sa…

This study follows 50 people who receive a Zimmer Biomet shoulder replacement implant to see if it safely improves pain, movement, and quality of life over two years. Participants have shoulder arthritis, fractures, or other joint damage. The main goal is to measure a meaningful …

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This early-phase trial tests whether a lab-grown urethra made from a patient's own cells can safely repair urethral strictures (narrowing of the urine tube) in adult men. Ten participants will receive the engineered tissue, and researchers will monitor for side effects and improv…

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This registry is following 240 people who receive the GORE VIABAHN VBX stent graft to treat blocked or damaged arteries in the abdomen, pelvis, or limbs. Researchers are tracking how well the device works and any serious side effects over time. The goal is to see if the stent gra…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can reduce deaths in people with severe bleeding from injury. About 1050 adults at risk of hemorrhagic shock will be randomly assigned to receive these treatments or placebo…

This study tests hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—for people with severe traumatic brain injury. Researchers will compare different oxygen pressures to see which works best. The goal is to improve long-term recovery and reduce brain swellin…

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This early study tests whether a daily supplement called gamma-glutamylcysteine (GGC) can boost the brain's natural antioxidant levels in people who have had repeated head impacts, such as retired NFL players and military veterans. The 30 participants will take GGC tablets for a …

This study tests a liquid agent called Onyx™ that is injected into arteries to block active bleeding outside the heart and brain. It includes 119 adults with severe bleeding from trauma, ulcers, or other causes. The goal is to see if it safely stops bleeding without needing furth…

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests a new 'nine-grid' method to guide needle placement during vertebroplasty, a procedure that stabilizes spine fractures caused by osteoporosis. Researchers will compare this technique to the standard approach in 68 adults with a single fractured vertebra. The goal …

This study tests whether a drug called 4-AP, taken twice daily, can boost recovery of leg movement in people with spinal cord injury. Participants also receive a type of brain stimulation and leg training. The goal is to improve walking and muscle strength. The study involves 27 …

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This study tests two non-invasive therapies to help people with chronic cervical spinal cord injury regain arm and hand function. Ten participants will try both therapies, each for two months, combined with rehabilitation. The goal is to see which works best and tailor treatments…

This study tests a device that sends electrical pulses to the spinal cord, combined with daily rehab, to help people with chronic spinal cord injury regain walking ability. Twelve participants will receive the implant and be followed for over a year. The goal is to see if the app…

This study tests whether a vacuum dressing (negative pressure wound therapy) reduces infection compared to standard bandages after skin graft surgery for leg tumors. About 242 adults will be randomly assigned to one of the two dressings. The main goal is to see if the vacuum dres…

This study tests whether combining cognitive training with brain stimulation (rTMS or tDCS) can improve thinking skills in veterans who have persistent symptoms after mild traumatic brain injury. Participants will receive 16 sessions of training with either real or sham stimulati…

This study tests whether a new antibiotic protocol can prevent infections in people with severe open fractures (where the bone breaks through the skin). The experimental group gets antibiotics applied directly to the wound before closure, plus extended systemic antibiotics. The c…

This early-stage trial tests a new antibody called HT31-1 in 24 healthy volunteers to see if it is safe and how the body processes it. The antibody targets a protein linked to inflammation in acute respiratory distress syndrome (ARDS), a severe lung condition often caused by infe…

This study tests whether giving blood transfusions quickly when hemoglobin drops can prevent delirium (sudden confusion) in patients 75 and older after hip fracture surgery. About 198 participants will be randomly assigned to either early transfusion or standard care. Researchers…

This study is testing a wireless brain implant that lets people with severe spinal cord injuries control external devices just by thinking. The device is placed in the brain with a small surgery. Researchers will check how well participants can perform tasks using only their brai…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This study tests whether using a lung imaging tool called EIT to set ventilator pressure (PEEP) can improve survival in patients with moderate-to-severe ARDS. The trial will enroll 2400 adults and compare EIT-guided PEEP to the standard method. The main goal is to see if this app…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This study compares two surgical methods to treat chronic ankle instability in people who also have joint hypermobility (very flexible joints). One method adds a special tape for extra support. The goal is to see which surgery provides better stability and fewer repeat injuries. …

This expanded access study offers stem cell therapy (HB-adMSCs) to up to 8 people with traumatic or non-traumatic brain injury who were not eligible for a related trial. Participants receive 6 intravenous infusions over 16 weeks. The goal is to evaluate safety and whether the tre…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study looks at whether having surgery sooner or later after a traumatic spinal cord injury leads to better recovery. Researchers will compare how much nerve function improves in 100 adults who get either early or delayed surgery. The goal is to find the best timing to help p…

This study compares a standard metal rod (nail) used to fix shinbone fractures with a new 'micromotion' nail that allows a tiny amount of movement at the break. Researchers want to see if the new nail helps bones heal faster and with fewer problems. About 100 adults with stable s…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests whether vitamin D3 supplements can reduce inflammation and improve recovery in adults with mild-to-moderate traumatic brain injury. Researchers will give different doses of vitamin D3 or a placebo to 240 participants and track their blood markers and neurological…

This phase 4 trial tests whether giving the NSAID ketorolac (Toradol) for the first five days after orthopedic trauma surgery can reduce the chance of patients still needing opioids six months later. About 458 adults aged 18–70 with acute musculoskeletal injuries requiring surger…

This study tests two approaches for children under 18 with life-threatening bleeding from trauma. One compares whole blood to standard blood components; the other tests tranexamic acid against placebo. The goal is to see which reduces death within 24 hours. Up to 1,000 children w…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study tests whether a combination of chemotherapy and radiation (total neoadjuvant therapy, or TNT) can shrink rectal tumors enough so that some patients can avoid surgery and instead be monitored closely. About 400 adults with early-stage rectal cancer will be randomly assi…

This study tests a device that stimulates a nerve in the leg to help people with spinal cord injury manage their bladder function at home. About 21 adults with chronic spinal cord injury (at level T9 or above) will use the device and be monitored for safety, reliability, and ease…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This Phase 2 trial at Johns Hopkins University will transplant donated hands onto 30 people who have lost one or both hands or arms. The key innovation is a bone marrow cell therapy designed to allow the body to accept the new hand with just one low-dose anti-rejection drug, inst…

This study tests whether a negative pressure wound therapy (NPWT) device, placed over the surgical incision, can reduce infections and other wound complications compared to standard dressings in people with severe leg fractures. The trial will enroll 352 patients with high-risk t…

This study tests whether a gel made from umbilical cord stem cells can help heal severe burns faster and more safely. About 90 adults with burns covering less than 30% of their body will receive either a low-dose, high-dose, or placebo gel on their donor skin site. The main goal …

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study compares two common surgeries for wrist fractures that involve the joint surface: a volar locking plate (a metal plate placed inside the wrist) and an external fixator (a frame outside the arm with pins into the bone). Researchers will measure how long the surgery take…

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and oxygen levels. The goal is to find a saf…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or an active drug to see if the treatments improve survival and are safe. The go…

This Phase 2 trial tests a drug called paridiprubart in hospitalized adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo as a single IV dose. The main goal is to see …

This study is testing whether taking an antibiotic pill for 7 days after surgery to fix a broken leg, ankle, or foot can lower the chance of wound infection in adults with poorly controlled diabetes. About 40 participants will either receive the antibiotic or standard care (no ex…

This study tests a medicine called vilobelimab in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and is safe…

This study tests whether a gel made from human umbilical cord stem cells and cow collagen can safely help third-degree burn wounds heal faster. About 108 adults with burns covering 1-5% of their body will receive the gel or a placebo. The main goal is to see how much and how quic…

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This pilot study tests whether giving trauma patients whole blood instead of separate red blood cells and plasma before reaching the hospital is feasible and improves outcomes. About 60 adults with severe traumatic bleeding will be randomly assigned to receive either two units of…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This study compares two types of zirconia materials used in full-mouth dental implants: monolithic zirconia (a single, solid ceramic) and zirconia-feldspathic (a ceramic with a porcelain veneer). Researchers will track complications like chipping, cracking, or other issues over a…

This early study tests a device called Mechanical Tissue Resuscitation (MTR) that is designed to drain excess fluid from the brain area after a person has had part of their skull removed or repaired. The trial will include 11 people who need a drain as part of their standard care…

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

This study tests whether pouring tranexamic acid (TXA), a drug that helps blood clot, directly into the surgical wound during spine surgery can reduce bleeding and the need for blood transfusions. About 252 adults with spinal injuries or deformities will be randomly assigned to r…

This Phase 3 trial tests whether antibiotic cement beads or negative pressure wound therapy (a wound vac) works better for severe open tibia fractures. 312 adults with these injuries will be randomly assigned to one of the two treatments. Researchers will compare death, amputatio…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests a program led by trained peers (other women with HIV) that combines acceptance and commitment therapy, exercise, and social support. The goal is to help 300 women in four counties stick to their HIV medication and manage substance use and trauma. Researchers will…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This study follows 120 people who need hip revision surgery (replacing a previous hip implant) to see how well the Prevision hip stem works. The stem comes in different versions, and surgeons choose the best one for each patient. The main goal is to measure how well patients can …

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This study tests a new way to create living skin during surgery for wounds that won't heal easily. Doctors take a small piece of the patient's own skin, separate out stem cells, and spray them onto a scaffold that is placed on the wound. The goal is to see if this helps wounds cl…

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study follows over 1,000 people who receive a shoulder replacement with FX Shoulder Solutions systems. Researchers will track how often the implant needs to be replaced (revision) and measure pain, movement, and quality of life for up to 10 years after surgery. The goal is t…

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of b…

This study tests whether injecting N-acetylcysteine (NAC), an antioxidant, into the ankle right after a severe pilon fracture can keep cartilage cells alive and reduce the chance of developing post-traumatic arthritis. Thirty adults with closed high-energy pilon fractures will re…

This study is following 584 people who received Zimmer Biomet shoulder implants to see how well the devices work over 10 years. Participants have shoulder arthritis, fractures, or deformities. Researchers will track implant survival, pain, function, and any side effects. The goal…

This study compares two common seizure medications, levetiracetam and lacosamide, to see which works better at preventing early seizures after a traumatic brain injury. Researchers will also track side effects like agitation and sedation. The trial plans to enroll 600 adults with…

This study tests whether an implanted device that sends electrical pulses to the spinal cord can improve movement and feeling in people with chronic spinal cord injuries. Ten participants with injuries above the T10 level will receive the implant and undergo regular assessments o…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This study tests a new surgical approach for complex fractures of the distal ulna (the forearm bone on the pinky side). The method uses both a flexible nail inside the bone and a small metal plate on the outside to hold the break together. Researchers will check how well the bone…

This early study is testing a device called ARC-IM Therapy, which delivers electrical impulses to the lower spinal cord, to see if it can help people with spinal cord injury regain the ability to walk. The trial will include 12 adults with recent or long-term injuries. The main g…

This early-stage trial tests whether draining fluid from the spine (external lumbar drainage) is safe and doable for people with severe traumatic brain injury who have high pressure inside the skull. Thirty adults aged 18-65 will receive either standard care alone or standard car…

This study is testing the safety and performance of the RibFix Titan™ device, used to fix broken ribs or during chest wall surgery. Researchers will follow 54 adults for 90 days after surgery to see how well the device works and if any additional procedures are needed. Participan…

This study tests whether functional electrical stimulation (FES) can improve arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove device to stimulate muscles during short therapy sessions. The goal is to see if this appr…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This study tests a bone substitute called Mg OSTEOCRETE in 10 adults with bone defects from tumor removal, loose orthopedic hardware, or trauma. The main goal is to measure how long it takes for the bone to heal after treatment. Researchers will also track patient-reported outcom…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This study tests whether adding a piece of donated hip bone (femoral allograft) to standard plate surgery helps people aged 40-70 recover better from severe shoulder fractures. Half the participants will get the graft plus a plate, the other half just the plate. Researchers will …

This study compares two common surgical methods—cannulated screws and K-wires—for fixing broken wrists in adults aged 18-60. The goal is to see which approach leads to better bone healing and hand strength. About 34 participants will be assigned to one of the two treatments and f…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study follows 300 people who receive the IlluminOss device to treat broken bones from injury or disease. Researchers will track how well the device works, how safely it performs, and how patients recover over time. The goal is to gather real-world data on bone healing and re…

This study tests whether special crutch tips with sensors can help heal a specific type of shinbone fracture. Thirty people who had surgery for a broken tibia will use the smart crutches for up to 24 weeks. The crutches give real-time feedback to guide how much weight to put on t…

This study tests whether special crutch tips that measure how much weight you put on your leg can help a broken shinbone heal better. Thirty people who had surgery for a tibial fracture will use the smart tips for up to 24 weeks, following a personalized walking plan based on CT …

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This phase 2 trial tests whether a 4-week course of an essential amino acid supplement can help older adults (65+) rebuild muscle after a hip fracture. Sixty participants will be randomly assigned to receive either the supplement or standard care alone. Researchers will measure m…

This study tests whether personalized weight-bearing instructions using smart crutch tips can help heal tibia fractures faster. Thirty adults who had surgery for a broken shinbone will use sensor-equipped crutch tips that give real-time feedback on how much weight they put on the…

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding in the brain. About 100 adults will receive the drug or a placebo within 24 hours of injury. The main goal is to see if …

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study tests a special wound dressing made from sheep stomach lining, used with a vacuum device, to see if it helps cover exposed bone or tendon faster than the vacuum device alone. About 30 adults with soft tissue wounds on an arm or leg will take part. The goal is to see if…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether semaglutide (Ozempic), a drug used for type 2 diabetes, works well for people with spinal cord injury (SCI) who also have diabetes. SCI patients are at higher risk for diabetes, but it's unclear if standard treatments are effective. The trial will measure…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study looks at whether a special vibrating device placed on the chest can improve breathing in older patients with a hip fracture who also have respiratory failure. 60 participants will receive the therapy for 5 days, and doctors will check their blood oxygen levels and lung…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study aims to create a blood test that helps doctors quickly diagnose traumatic brain injury (TBI) and predict how patients will recover. Researchers will collect blood samples from 2,000 adults with suspected TBI in emergency rooms and hospitals. The goal is to find specifi…

This study is testing whether a bedside ultrasound can accurately detect skull fractures in children aged 6 and under who have minor head injuries with a scalp bruise. Researchers will compare ultrasound results to a standard CT scan in 150 children. If ultrasound proves reliable…

This study looks at whether older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will check 75 patients with a physical exam and, if needed, an MRI before they leave the hospital. The goal is to fi…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study tests whether a very powerful 7 Tesla MRI can detect tiny brain injuries in people with post-concussion syndrome after a mild head trauma. Researchers will scan 100 patients one week after their injury and compare the results to standard tests. The goal is to see if th…

This study is testing a new device that scans the eyes to find signs of mild traumatic brain injury (TBI). The device looks at how the eyes move and focus, which can be affected by a brain injury. Researchers will scan 60 people with a recent head injury and 20 healthy volunteers…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study tests a new iPhone app called Senseye DT that uses artificial intelligence to diagnose Post-Traumatic Stress Disorder (PTSD) in adults. Participants will use the app while it records video of their face, and the AI looks for signs of PTSD. The goal is to see if the app…

This pilot study tests a new device called WounDx that gives surgeons information about a wound to help them decide when it's ready to be surgically closed. The study will enroll 40 people with large extremity wounds. The goal is to see if the device can be used smoothly in a hos…

This study looks at whether a special ultrasound (CEUS) can find hidden bleeding pockets (pseudoaneurysms) in the liver, spleen, or kidneys after an injury, just as well as the standard CT scan. About 385 adults with abdominal trauma will be followed over time with both tests. If…

This study tests a drug called BX-001N to see if it can prevent acute kidney injury in people having heart surgery. About 40 adults will receive either a low dose, high dose, or a placebo. The goal is to see if the drug can keep kidneys working well after surgery.

This study tests if teaching people how to use mobility devices like crutches or walkers before foot or ankle surgery can lower their risk of falling after the operation. About 250 adults having elective foot or ankle surgery will take part. The goal is to see if this simple trai…

This study tests whether applying paraffin oil to the skin before using a tourniquet (a tight band that stops blood flow) during arm surgery can prevent skin injuries like redness, blisters, or burns. About 90 adults having elective upper arm surgery will be randomly assigned to …

This study tests a community violence prevention program for adults who have been hospitalized with a gunshot wound in Central Arkansas. The program offers bedside support, peer mentoring, and case management to help people stay safe and address mental health needs. Researchers w…

This study tests whether coating a metal rod (intramedullary nail) with antibiotics (vancomycin and gentamicin) can prevent deep infections in people with severe open tibia fractures. About 484 adults with Gustilo Type II or III open tibia fractures will be randomly assigned to r…

This study tests an online program called Store Safely that teaches rural families with children how to store firearms more safely. The program includes videos, facts, and a personalized action plan. Researchers will check if families lock up more guns after using the program. 60…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether a brief counseling program called BeSMART, given to parents while their child is in the hospital, can improve how they store firearms at home. About 400 caregivers of hospitalized children will be randomly assigned to receive the counseling or usual care.…

This study tests a smartphone app designed to help people who use wheelchairs or scooters prevent and manage falls. Researchers will compare the app to standard fall prevention information in 120 adults with spinal cord injury or multiple sclerosis. The goal is to see which appro…

This study looks at whether a special prosthetic ankle that reads muscle signals can help people with below-knee amputations improve their balance and stability. About 50 adults who have had an amputation for at least two years will train with this powered ankle and be compared t…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study will compare three pain management methods after hip surgery in 108 adults aged 65 and older. The methods are a nerve block (PENG block), a local anesthetic injection around the joint (periarticular injection), or both combined. The goal is to see which approach reduce…

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests whether a therapist-guided exercise program helps people aged 50 and older recover better from a wrist fracture compared to usual care advice. Participants will either receive supervised exercises or standard self-management advice. The main goal is to see if the…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study compares buprenorphine to a standard opioid (hydromorphone) for pain relief in adults aged 65 and older who come to the emergency department with a broken bone. Researchers want to see if buprenorphine works just as well but causes fewer side effects like nausea, confu…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether a device that delivers high-frequency radiofrequency electrical currents (called TECAR) can reduce pain and improve movement in people with muscle injuries or low back pain. Researchers will measure pain, flexibility, and function before and after a singl…

This study tests the Point Mini, a mechanical finger prosthetic, in 14 children aged 3-17 with partial hand differences from amputation or birth. Each child uses their current device for one month, then the Point Mini for two months, to compare hand function, ease of use, and how…

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This study tests whether early, symptom-guided therapy can prevent long-term complaints after mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, psychoeducation by phone, or usual care. The goal is to reduce post-concussion…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study tests whether a walking program on uneven surfaces can improve walking skill and confidence for people who use a lower-limb prosthesis. Thirty-five adults with leg amputations will practice walking on flat and uneven treadmills for four weeks. Researchers will measure …

This study tests a smartwatch-based system that gives real-time tips and reminders to help people with spinal cord injury increase their physical activity. About 196 adults who use wheelchairs will be split into two groups: one gets a standard web-based exercise program, and the …

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study tests whether taking creatine supplements after a concussion helps people recover faster. Twenty adults aged 18–35 with a recent concussion will either take creatine or follow their usual diet. Researchers will track how many days it takes to become symptom-free and co…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have ongoing pain after a serious orthopedic injury. Researchers want to see if it's possible to run a larger study by checking how many people sign up, attend sessions…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This pilot study tests whether combining a gentle nerve stimulator placed on the ear (taVNS) with robotic tilt-table therapy can safely help people with prolonged disorders of consciousness after severe brain injury. Fifteen participants will undergo 12 weeks of paired therapy, a…

This study compares two ways of delivering cognitive processing therapy (CPT) to pregnant women with posttraumatic stress disorder (PTSD). One group receives standard weekly therapy sessions for 12 weeks, while the other gets an intensive schedule of 10 sessions over just 5 days.…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study compares two remote training programs for 300 people who have had a mild traumatic brain injury (concussion) and struggle with emotional awareness and regulation. One program teaches participants to recognize and label their emotions, while the other focuses on general…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study tests whether deep brain stimulation (DBS) can improve walking in people with incomplete spinal cord injury. Six adults who have had a spinal injury for at least one year will receive DBS to a brain area called the cuneiform nucleus. The goal is to see if it safely hel…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests whether a low-volume nose resistance breathing exercise using an Acapella device plus an incentive spirometer can improve lung function and reduce shortness of breath, cough, and phlegm in people with cervical spinal cord injuries. Forty-two inpatients aged 18–38…

This study looks at mothers who feel severe pain during a C-section despite spinal or epidural anesthesia. It compares giving general anesthesia versus extra pain medicine to see which better prevents post-traumatic stress disorder (PTSD). The goal is to find a way to reduce trau…

This study tests a silk-based wound dressing against a standard adhesive dressing in 50 adults undergoing double-incision mastectomy for female-to-male gender affirmation. Each patient serves as their own control, with one side of the chest getting the silk dressing and the other…

This study tests whether adding virtual reality (VR) exercises to standard physical therapy can improve hand function, reduce pain, and speed recovery in adults with traumatic wrist or hand injuries. About 40 participants will receive either usual rehab alone or usual rehab plus …

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This early study is testing a mineral-based spray called THERAVEX on 26 people with various wounds, including burns, pressure sores, and diabetic ulcers. The spray is used alongside standard wound care to see if it helps the skin heal better and faster. So far, it appears safe an…

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a traumatic spinal cord injury, is safe and might help patients recover movement. Fifteen adults with acute spinal cord injury will receive either real or sham sti…

This study tests a live, group tele-exercise program (TEEMS) for people with spinal cord injury. Researchers want to see if it improves exercise confidence, physical activity, and quality of life compared to watching pre-recorded exercise videos. The program is fully virtual to m…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve mobility recovery in elderly patients after hip fracture surgery. Researchers will compare the iron group to a placebo group in 210 participants across three Danish hospitals. The main g…

This pilot study is testing whether a home-based virtual reality exercise program called VR-Move can improve fitness and quality of life in people with spinal cord injuries. Sixteen participants will use the VR system three times a week for 12 weeks. The goal is to provide an acc…

This study tests whether taking a short chain fatty acid supplement can reduce gut-related side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 adults will be randomly assigned to receive either the supplement or a placebo. The goal i…

This study tests whether hypnosis before getting stitches in the emergency room can lower pain and stress. 180 adults with stitchable wounds will either receive standard care or a short hypnosis session before the procedure. The main measure is heart rate variability, and patient…

This study is testing a wearable robotic exoskeleton called ABLE Daily to see if it is safe and works well for helping people with spinal cord injury walk in their home and community. Ten participants will train with the device at a clinic for three weeks, then use it on their ow…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests two different therapies to help people with ongoing memory problems after a concussion. One is traditional cognitive rehabilitation, and the other is a new cognitive-behavioral therapy (CBT) approach. Researchers want to see which one works better for improving h…

This study compares two types of nerve blocks (meta-PENG and fascia iliaca) to see which one better reduces pain during hip fracture surgery. About 80 adults having hip fracture surgery will receive one of the blocks as part of their routine care. The goal is to find which block …

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study looks at how older adults (ages 65-74) who live alone and have limb injuries experience recovery. Researchers are testing a special "Geriatric Trauma Care Program" to see if it can improve pain, daily function, mood, and loneliness. About 110 participants will join for…

This study tests a new anonymous online therapy program called Restory for people with PTSD after sexual abuse. It is designed for 140 adults who have experienced sexual violence at least one month ago. The therapy uses a type of talk therapy done over the internet, and the goal …

This study tests whether strengthening the ankle, the hip, or both together works best for people with chronic ankle instability. 45 participants aged 18-35 will do isometric exercises three times a week for four weeks. Researchers will measure improvements in stability, strength…

This study tests whether daily training with colored lights can reduce light sensitivity in people who have had a traumatic brain injury. Twenty participants will use a device at home for 20 minutes a day, first with a blue light and then with a red light, or vice versa. Research…

This study looks at whether a new type of nerve block, called the Quadro-Iliac Plane (QIP) block, helps people recover better after hip replacement surgery. Researchers will compare it to other standard blocks by measuring pain, how quickly people get up and move, and overall rec…

This study tests whether daily symptom tracking via smartphone can help teens with concussion get quicker access to specialty care. About 210 teens aged 13-18 who visit the emergency department with a concussion and are at high risk for long-term symptoms will report their sympto…

This study compares two approaches for breast cancer patients who still have cancer in their sentinel lymph node after chemotherapy: removing the underarm lymph nodes (surgery) or treating them with radiation. The goal is to see if radiation can reduce the risk of arm swelling (l…

This study tests whether a week of accelerated brain stimulation (25 sessions over 5 days) can quickly reduce PTSD symptoms. It involves 132 adults with PTSD, including those with traumatic brain injury. The goal is to see if this fast-paced treatment works better than a placebo …

This study tests whether a cold helium plasma device is safe and tolerable for people with chronic wounds, such as leg ulcers or pressure sores. About 40 adults with wounds that have not healed for over 4 weeks will receive the treatment. The goal is to see if cold plasma can red…

This study tests whether a special laser can make burn scars look and feel better. Researchers will treat mature burn scars on the body and measure changes in scar height, texture, color, and flexibility. The study involves 6 adults in Winnipeg with scars that are 6-12 months old…

This study tests whether a drug called phenylephrine can control bleeding during burn surgery as well as the standard drug epinephrine, but without causing unwanted changes in heart rate or blood pressure. About 24 adults with burns needing skin grafts will take part. The goal is…

This study tests a special gel dressing called Plurogel against standard burn dressings in people with partial thickness burns on the face or one limb. The goal is to see if Plurogel helps burns heal faster, reduces pain, and lowers the need for skin grafts. About 25 adults will …

This early-phase trial tests whether disposable nitrous oxide (laughing gas) canisters can reduce pain and anxiety during burn dressing changes. Thirty adult burn patients will try both the gas and a placebo in random order. The goal is to see if this offers a safer alternative t…

This study tests whether a structured prenatal yoga program can reduce how traumatic women perceive childbirth to be, and improve their self-image and delivery preferences. Forty-six pregnant women in their second trimester or later will attend eight yoga sessions over four weeks…

This pilot study tests whether a gel called PluroGel®, used with standard dressings, can help burn injuries heal better and reduce the need for skin grafting. Twenty adults with similar burns on both arms or legs will have one limb treated with the gel and the other with standard…

This pilot study tests whether a trauma-focused therapy (TF-CBT) adapted for autistic youth is practical and well-received in community mental health centers. About 24 autistic children and their therapists will participate. The goal is to see if the therapy is acceptable and fea…

This study tests whether using blood flow restriction cuffs during low-intensity stationary cycling can safely improve muscle strength and mobility in older adults recovering from a hip fracture. Sixty hospitalized patients over age 65 will be randomly assigned to either real or …

This study tests whether community health workers can help caregivers of people with traumatic brain injury (TBI) during the move from rehab to home. About 126 adult caregivers will get either standard support or extra help from a health worker starting before discharge. The goal…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study looks at whether pulsed dye laser therapy can make burn scars less red, softer, flatter, and more flexible. Researchers will treat people with burn scars that are 1 to 6 months old and living in Winnipeg. The goal is to see if the laser helps scars heal better.

This study tests whether adding shock wave therapy to standard hand rehab can improve movement, reduce pain, and increase grip strength after a flexor tendon injury. About 56 adults who had tendon repair surgery 8-12 weeks ago will take part. Half will get usual rehab, and the ot…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study tests whether a smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. About 50 participants will use either a basic or interactive app, and those who struggle may get extra coaching. The goal is to find the best way to boos…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study tests a new prosthetic socket that automatically adjusts to daily changes in limb size for people with below-knee amputations. The goal is to improve comfort, prevent skin problems, and reduce the need for manual adjustments. About 100 adults who have used a prosthesis…

This study tests whether a 12-week pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Thirty participants will do exercises five times a week. Researchers will track how many people join, stick with the program, and …

This study tests whether a structured nutrition plan helps people recover physical function after abdominal trauma surgery. Participants are adults in the ICU who need nutrition through an IV. They are randomly assigned to either the structured plan (IV nutrition, then shakes for…

This study tests a 3D-printed adapter that snaps onto an Xbox controller, allowing children aged 7 to 17 with a one-sided upper limb difference to use almost all buttons with one hand. Researchers want to see if it improves gaming performance and enjoyment. Twenty participants wi…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study looks at whether using a continuous passive motion (CPM) machine—a device that gently moves the leg—can help control pain and reduce the need for strong painkillers after surgery for certain leg fractures. About 100 adults who have had surgery for a broken hip socket, …

This study looks at whether giving children a nerve block before elbow fracture surgery can help control pain afterward and reduce the need for strong painkillers like oxycodone. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either …

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers wi…

This study tests whether a short-arm fiberglass cast works as well as a long-arm cast for stabilizing certain forearm fractures in children aged 4 to 16. The goal is to see if the shorter cast provides enough support while being more comfortable. About 120 children with Salter Ha…

This study tests whether putting tranexamic acid (a medicine that helps blood clot) into the surgical wound before closing it can reduce pain and the need for painkillers after wrist fracture surgery. About 90 adults having surgery for a broken wrist will be randomly assigned to …

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This study tests a cream containing FS2 (kynurenic acid) to see if it can reduce scarring in burn patients who need skin grafts. About 70 people aged 12 to 65 will apply the cream or a placebo to both the graft and donor sites for 90 days. The goal is to check safety and whether …

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study looks at whether a new preservative-free eyelid cream helps people feel more comfortable after eyelid surgery. About 30 adults who are planning eyelid surgery will use the cream twice a day for 3 months. Researchers will measure how satisfied patients are with their ey…

This Mayo Clinic study tests whether using a virtual reality (VR) headset can reduce pain and the need for opioid painkillers in 100 adults hospitalized with a broken bone. Participants will use a VR program while in the hospital, and researchers will track their pain medication …

This study tests whether using CPAP or BiPAP breathing machines can reduce tumor movement during radiation therapy for lung cancer, esophageal cancer, or lymphoma. About 31 adults with advanced but treatable cancers will try these machines during treatment. The goal is to see if …

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and daily function in 15 people with mild traumatic brain injury (mTBI) who have trouble sleeping. Participants will learn techniques like sleep scheduling and changing unhelpful tho…

This study tests whether socks made with semiconductor fabric can improve healing and reduce symptoms after an ankle sprain. About 100 adults with ankle injuries will wear either the special socks or regular compression socks and report their pain and function over time. The goal…

This pilot study is testing a special capsule that vibrates as it moves through the digestive system. The goal is to see if it is safe and helpful for people with spinal cord injuries who have bowel problems. Only 12 participants will be enrolled to check safety and how well they…

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests whether a semi-elemental liquid diet (a pre-digested formula) reduces stomach and bowel issues like vomiting, diarrhea, and bloating in patients with severe traumatic brain injury. About 100 adults will receive either the special formula or standard liquid nutrit…

This study tests Emotional Freedom Techniques (EFT), a stress-reduction method that involves tapping on specific body points, in smokers who have failed standard quit programs. Researchers want to see if EFT can improve quit rates by reducing anxiety and cravings. The trial enrol…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether adding a lightweight SAM splint to usual pain relief helps adults with suspected wrist fractures feel less pain while waiting for X-rays in the emergency department. About 120 participants with moderate to severe pain will be randomly assigned to get a sp…

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…

This study tests whether practicing driving skills in a simulator can improve real driving performance in veteran stroke survivors. One hundred participants will complete both active training (focusing on speed, lane position, collision avoidance, and attention) and a control ses…

This study tests whether adding cognitive processing therapy (CPT) to standard relapse prevention (RP) helps people with both PTSD and alcohol use disorder more than RP alone. About 200 adults with moderate to severe alcohol use disorder and current PTSD will receive either CPT+R…

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study tests a new, single-session therapy called PATH-SS for people struggling with PTSD or depression after a sexual assault. Researchers want to see if this brief treatment reduces distress and is helpful to participants. The study involves 45 adults in Ohio who experience…

This study compares two types of nerve blocks—suprainguinal fascia iliaca block (SIFI) and quadro-iliac plane block (QIPB)—for pain relief after hip fracture surgery. Researchers will enroll 70 adults undergoing hip fracture repair and measure pain scores and opioid use. The goal…

This study tests whether pelvic floor physical therapy can reduce bowel and bladder control problems that often happen after radiation for cervical cancer. Twenty-eight women who are getting pelvic radiation will start physical therapy four weeks after finishing radiation. The th…

This study tests a new approach that combines magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation to improve hand, leg, and trunk function in people with spinal cord injury. Researchers will enroll 25 participants, including both injured and abl…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests a new multi-speed ergonomic wheelchair designed to reduce shoulder overuse injuries common in manual wheelchair users. Thirty adults who use a manual wheelchair daily will try different gear ratios on various surfaces. The goal is to see if the design improves pr…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study tests a portable virtual reality system that guides eye exercises to help veterans with mild traumatic brain injury improve their eye coordination. About 80 veterans will be split into two groups: one receiving active therapy and the other a sham version. The goal is t…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

This study looks at whether pelvic floor muscle training is practical and helpful for people recovering from a spinal cord injury during inpatient rehab. Researchers will recruit 50 participants to do pelvic floor physiotherapy five times a week for six weeks. The goal is to see …

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study compares a nonopioid pain control plan to standard opioid pain medicine in 75 adults after surgery for a broken collarbone. The goal is to see if the nonopioid plan can control pain just as well while reducing opioid side effects and addiction risk. Participants are ra…

This study tests whether a 3D hologram can distract children aged 3 to 12 during painful burn dressing changes, reducing their pain, anxiety, and fear. About 70 children with second-degree burns covering less than 10% of their body will be randomly assigned to see a hologram or r…

This pilot study tests whether a topical diclofenac gel (Voltaren) works as well as oral ibuprofen for reducing pain in children aged 6-18 with ankle or knee sprains. Sixty participants will use either the gel or oral medicine three times a day for three days, then report their p…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study tests whether using a medical glue (cyanoacrylate bioadhesive) instead of stitches to close the wound on the roof of the mouth after gum graft surgery leads to less pain and faster healing. Sixty-six healthy adults will be randomly assigned to receive either stitches o…

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study tracks how much radiation doctors are exposed to while performing robotic-assisted lung biopsies. About 350 procedures will be monitored across multiple hospitals using special badges. The goal is to understand current exposure levels and help make the procedure safer …

This study looks at how blood pressure changes in the first year after a spinal cord injury and whether a device that stimulates the spine through the skin can help. Five people with recent injuries will be followed for a year, testing the stimulation during sessions to see if it…

This study will follow 1,000 people receiving Medtronic spinal or cranial devices during routine surgery. Researchers will track outcomes like fusion success, pain relief, and device safety for up to two years. The goal is to gather real-world data on how these already-approved p…

This study tests whether a set of simple decision rules, adapted from the Canadian C-Spine Rule, can help emergency responders decide when a neck collar and hospital imaging are truly needed. Researchers will enroll 840 stable, conscious adults with recent neck trauma treated by …

This study tests whether combining 4D MRI and 4D CT scans can better track lung tumors and nearby organs as a person breathes during radiation therapy. Researchers will compare this new method to the current standard. The goal is to see if it improves targeting of the tumor while…

This study looks at whether two different training programs can improve emotional health in people who have had a moderate to severe traumatic brain injury. About 48 adults will take part in 8 one-on-one sessions over a month, learning either to recognize emotions or adopt health…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing diffe…

This study compares brain health in 300 former professional football players (ages 29-59) to a similar group of men who did not play football. Participants will undergo cognitive tests, balance and eye-movement exams, sleep assessments, and high-resolution MRI scans. The goal is …

This study looks at 200 children with minor head trauma to see if family education, income, and health literacy influence parents asking for a CT scan. Doctors already have a rule (PECARN) to decide when a CT is needed, but parents sometimes request one anyway. The goal is to und…

This study looks at whether a harmless thermal camera can help doctors see how surgical wounds are healing after skin surgery. About 120 adults having skin lesions removed will have their wounds photographed with the camera. The goal is to catch problems like infection or slow he…

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This study compares carbon dioxide emissions from orthopedic surgeries performed with different materials and setups. Researchers will track waste, energy use, and sterilization methods for procedures like carpal tunnel release or wound revision. The goal is to identify ways to r…

This study is developing and testing a 12-week group education program called FEELS to help Black young adults (ages 18-35) who have experienced trauma better understand mental health and substance use. Participants will attend weekly sessions and complete surveys to see if their…

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study follows about 100 adults who received a Tipmed hip replacement during routine care. Researchers track complications and hip function over two years to see how well the device performs in real life. The goal is to gather practical evidence on safety and effectiveness, n…

This study aims to establish normal knee rotation values in healthy athletes who play pivot sports like soccer or basketball. Researchers will measure knee rotation in 482 athletes using a device called DYNEELAX. The goal is to better understand what is normal, so doctors can ide…

This study is testing whether giving elderly patients with a broken hip and high frailty a special nutritional drink before surgery can help them stay more stable during the operation and recover better. Researchers will compare patients who get the drink with those who follow st…

This study follows about 400 young rugby players (ages 12-18) from Rugby Club Toulonnais over two seasons. Researchers will record every injury that needs medical care, noting how often injuries happen, how serious they are, and what types occur. The goal is to understand injury …

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…

This study will review medical records of 100 trauma patients with colon injuries treated at Methodist Dallas Medical Center. Researchers want to see which surgical approaches lead to the best outcomes. No new treatments are being tested; instead, the goal is to learn from past c…

This study looks at how a serious burn injury changes the way cells produce energy. Researchers will collect blood, urine, and tissue samples from 125 children and adults admitted to the burn center. No new treatments are tested; the goal is simply to learn more about the body's …

This study looks at blood from people with ARDS, a severe lung condition with no specific medicines. Researchers will take immune cells from the blood and test a new blocking agent in the lab to see if it can reduce lung damage. The goal is to learn more about the disease and fin…

This study looks at whether starting physical therapy 2 weeks after reverse total shoulder replacement (for a broken upper arm bone) is better than waiting 6 weeks. Ten adults aged 50-85 will be randomly assigned to one of the two rehab schedules. The goal is to see which timing …

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study looks at two ways to treat pelvic fractures in people aged 60 and older: surgery or non-surgical care. Researchers will follow 120 patients to see if a larger trial comparing these treatments is possible. The goal is to understand patient and surgeon preferences and wh…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study explores whether injecting special skin cells (fibroblasts) can change normal skin into the thicker skin found on palms and soles. Researchers will take a small skin sample, grow the cells in a lab, and inject them back into the skin. They will measure changes in cell …

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This study looks at whether offering free legal help to people recovering from violent injuries like gunshot wounds can lower stress and improve their health. Researchers will work with 500 patients at a trauma center to address problems like housing or money issues that often le…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study follows 15,000 people with various spinal conditions (like stenosis, fractures, infections, or cancer spread) to see how their quality of life changes over 5 years. Participants fill out questionnaires about their health and daily activities. The goal is to understand …

This study will use data from 1,200 hip fracture patients to build a machine learning model that predicts mobility and daily living independence three months after injury. The goal is to help patients and doctors set realistic expectations for recovery. No new treatments are bein…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to doing them by hand. Sixty adults who are …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study tests whether a simple manual chest compression technique works as well as electrical impedance tomography (a special imaging method) to find the best ventilator pressure for people with acute respiratory distress syndrome (ARDS). Thirty adults on ventilators will have…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study is testing whether a robotic ultrasound device can safely and effectively monitor blood flow in the brains of people with severe traumatic brain injury. The device is designed to work automatically for long periods, even in hospitals with little ultrasound experience. …

This study is observing nearly 2,700 active-duty service members to find out what makes them more likely to get muscle or bone injuries. Participants will do physical tests and answer questions to identify risk factors. The goal is to create better ways to prevent injuries and he…

This study tests whether keeping the thumb in a cast for four weeks after surgery reduces the risk of tendon rupture compared to the standard early active motion therapy. About 380 patients in Sweden will be randomly assigned to one of the two rehab programs. The goal is to find …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study looks at whether a special mobility program, designed with input from patients and doctors, can help older adults move more after hip fracture surgery. About 25 participants will try the program during their hospital stay. Researchers will check if the program is pract…

This study is tracking 561 people who have already had spine surgery using METROSAN spinal implants and BONEGRAFT bone fillers. Researchers want to see how well these devices work and if any new safety issues pop up over a year. It's an observational study, meaning patients get s…

This study follows 150 older adults who survived a stay in the intensive care unit (ICU) for sepsis or lung injury. Researchers will measure muscle strength and physical function at hospital discharge and again at 3, 6, 12, and 24 months later. A small group will also have muscle…

This study from Mayo Clinic looks at how the body manages blood pressure after a spinal cord injury and whether those changes can predict future health problems. Researchers will test 18 people with spinal cord injuries (either recent or long-term) using simple procedures like co…

This Mayo Clinic study is looking at how spinal cord stimulation affects blood pressure, heart rate, and immune function in people with spinal cord injuries. Researchers will test how the body handles changes in blood pressure using simple tasks like hand cold pressor tests and b…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study looks at whether surgery improves walking in older adults with pelvic ring fractures. Researchers will compare walking patterns and hospital outcomes between those who get surgery and those who don't. The goal is to see if surgery leads to better recovery and quality o…

This study looks at how a simulated burn injury affects how quickly the body cools down after exercise in hot conditions. Researchers will compare the same person's recovery with and without a special material on the skin that mimics a burn. The goal is to understand if burn surv…

This study looks at whether doctors can rely on feeling a patient's pulse (in the neck, groin, or wrist) to know if their blood pressure is dangerously low during shock. Researchers will compare pulse checks with standard blood pressure readings in 5,000 critically ill adults in …

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study looks at how adults with acquired brain injury (like from stroke or trauma) learn connections between things without being directly taught. Researchers will test 40 participants using a task that links pill shapes, functions, and names. The goal is to understand how br…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study looks at how doctors decide to use brain CT scans for people with mild head injuries in emergency rooms. Many CT scans come back normal, exposing patients to unnecessary radiation and increasing costs. Researchers will analyze data from 2,500 adults across Italy to und…

This study looks at whether a breathing technique called acute intermittent hypoxia (AIH) increases spasticity (muscle tightness) in people with chronic spinal cord injury. Ten adults with incomplete spinal cord injury will receive AIH and have their reflexes and muscle stiffness…

This study looks at why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks in 300 participants to understand the underlying causes. The goal is to better classify pain types, not to test a new trea…

This study follows 100 adults who had surgery for traumatic nerve injuries in the hand or arm. Researchers will measure hand function, strength, and quality of life over time to better understand long-term recovery. The goal is to gather information, not to test a new treatment.

This study looks at why some infants develop lung injury after heart surgery that uses a heart-lung machine. Researchers will collect blood and fluid from the lungs of 56 babies under 1 year old to study how their immune cells (neutrophils) behave. The goal is to better understan…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study enrolls people who have already had a hand or arm transplant to collect information over time. Researchers will measure hand function, pain, quality of life, and mental well-being using questionnaires and tests. The goal is to better understand the long-term safety and…

This study follows 150 adults who need surgery for a broken upper arm bone (proximal humerus fracture) using the ALPS plating system. Researchers will measure shoulder strength, movement, and pain, and track any complications. The goal is to see how well this surgical tool perfor…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study will video-record occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to understand exactly what therapists do to help patients improve arm and hand movement. The goal is to create a toolkit that makes rehabilitation …

This study looks at adults aged 18-70 who have a specific type of broken back (thoracolumbar burst fracture) but no nerve damage. Half will get surgery to fuse the spine, and half will wear a brace for six weeks instead. Researchers want to see if avoiding surgery works just as w…

This study is testing whether a non-invasive brain stimulation technique called iTBS, combined with computer-based attention training, can improve focus and daily functioning in people with persistent attention problems after a mild traumatic brain injury (mTBI), with or without …

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study looks at whether people with a torn ACL have weakness in the soleus, a calf muscle that helps protect the knee. Researchers will test leg strength in 55 participants with ACL tears and compare them to healthy individuals. The goal is to better understand muscle changes…

This study tests whether mild electrical stimulation of a nerve in the forehead can improve blood flow and waste clearance in the brain. Researchers will measure changes in brain fluid flow using MRI and light-based imaging in 55 healthy adults and people with mild traumatic brai…

This study tests a new computer system called SeeMe that can detect tiny movements in people with severe traumatic brain injury (TBI). Current exams may miss these movements, leading to misdiagnosis. The study will involve 60-80 TBI patients and aims to see if SeeMe can find sign…

This study is developing a standard test to measure how well assistive technologies (like eye trackers) and brain-computer interfaces help people with spinal cord injury or ALS use computers and phones. Researchers will test 60 participants, including healthy volunteers and peopl…

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study is looking at whether measuring two proteins in the blood (NF-L and GFAP) soon after a spinal cord injury can help doctors predict how severe the injury is and how much recovery a person might have 6 months later. Researchers will enroll 260 adults with traumatic spina…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study looks at whether older adults who are frail before hip fracture surgery have higher levels of inflammation, measured by simple blood tests. Researchers will enroll 200 patients aged 65 and older and check their frailty using a standard questionnaire. The goal is to bet…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at how different laser energy levels affect skin damage and repair. Twenty healthy Chinese women will receive various laser doses on their forearms. Researchers will track changes in skin color, moisture, and healing over 10 days. The goal is to create a model fo…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study looks at whether a computer program called BrainHQ can help adults with traumatic brain injury improve their memory and attention. About 150 people with mild to severe brain injuries will either use BrainHQ or play regular brain games. Researchers will test their think…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This study follows 300 people with a broken wrist (distal radius fracture) to understand their pain, hand function, and use of painkillers or splints during the first three months. Participants will fill out daily and weekly questionnaires. The goal is to learn what recovery real…

This study looks at how a moderate traumatic brain injury (TBI) from early or middle adulthood might speed up physical and mental decline in older age. Researchers will test balance and thinking in 70 Veterans aged 50-75 who had a TBI at least 15 years ago, even if they feel fine…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to mod…

This study looks at how different meals affect energy use and appetite in men with high spinal cord injury (T6 and above) compared to able-bodied men. Participants will eat standardized meals and have their metabolism measured. The goal is to understand how food impacts cardiovas…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study follows 100 adults who had a traumatic brain injury and completed 60 sessions of hyperbaric oxygen therapy. Researchers will test their thinking, memory, and quality of life 1 to 4 years later to see if improvements stick. The goal is to understand the long-term effect…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study compares two recovery approaches after surgery for pelvic fractures: starting to put weight on the leg immediately versus waiting a while. Researchers will track 50 adults aged 18 to 55 to see which group has better function, less pain, and stronger muscles. The goal i…

This study looks at whether a new way of organizing hospital care, called an Acute Medical Unit, can help older adults with sudden illnesses like infections or COPD get better faster and spend fewer days in the hospital. Researchers will compare 220 patients who receive this new …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This observational study will collect movement data from 5,000 healthy athletes aged 10 to 65 who play organized sports. Researchers will track participants for 12 months to see who gets injured, especially ACL tears. The goal is to build a database of normal movement patterns to…

This study exposes small areas of sun-damaged skin to simulated sunlight to see how proteins and genes change. Researchers will compare 46 adults—half with a history of skin cancer, half without—to find differences that might explain cancer risk. Participants will have four small…

This study looks at whether imagining certain movements or scenarios can trigger or worsen headaches and dizziness in people who have had a mild traumatic brain injury or concussion and still have symptoms months later. Researchers will ask 60 adults to imagine movements that usu…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study looks back at medical records of 5,000 adults who had blunt trauma to the chest or belly area. Researchers want to learn how often the adrenal gland is injured and how that affects recovery. The goal is to better understand this rare injury, not to test a new treatment…

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study looks at whether wearing a rigid neck collar is needed for stable neck fractures. About 616 adults with these fractures will be treated either with a collar for 12 weeks or without one. The goal is to see if both approaches lead to similar healing, while avoiding colla…

This study looks at how much fluid doctors should use when cleaning open fractures (broken bones that poke through the skin). About 200 adults will join for 12 months. Researchers will compare two different fluid amounts to see if one helps bones and wounds heal better with fewer…

This study looks at two types of spine surgery for people with broken back bones. One is a traditional open surgery, the other is a less invasive method. Researchers will use 3D walking analysis and muscle activity tests to see which approach helps patients recover better. The go…