Your gut bacteria might predict brain radiation injury risk

NCT ID NCT07767981

First seen Aug 17, 2026 ยท Last updated Aug 17, 2026

Summary

This study looks at whether the bacteria in your gut can help predict who might experience side effects from stereotactic radiosurgery (SRS), a precise type of radiation used to treat brain tumors. Researchers will collect stool and blood samples from 150 patients before and after their standard SRS treatment, and track their recovery over time. By comparing the gut microbiome and metabolic profiles of patients who develop radiation injury versus those who don't, the study aims to uncover biological clues that could improve risk prediction and guide future care.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Observational study with no intervention; examines gut microbiome and metabolites
What this could lead to
If successful, this could lead to a simple stool or blood test to predict which patients are at higher risk for radiation-induced brain injury, enabling personalized monitoring and preventive strategies.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to all patients or treatment settings, and the microbiome is highly variable, making it challenging to identify reliable signatures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Chicago

    RECRUITING

    Chicago, Illinois, 60637, United States

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