Could an Alzheimer's drug help treat metabolic syndrome in spinal cord injury?

NCT ID NCT07625332

Recruiting now Disease control Sponsor: Northwell Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related waist measurements. Participants will take galantamine for 12 weeks, starting at 8 mg and possibly increasing to 16 mg daily, while researchers monitor side effects and changes in inflammation markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Galantamine (Razadyne ER)
What this could lead to: If it works, this could point toward a new way to manage metabolic syndrome and reduce inflammation in people with spinal cord injury.
What could go wrong: This is a small early-stage pilot study (60 people) testing a drug already approved for Alzheimer's, so it may not work for this new use. Side effects like changes in heart rate and blood pressure are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X paraplegia quadriplegia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METABOLIC SYNDROME PARAPLEGIA AND TETRAPLEGIA SPINAL CORD INJURY TRAUMATIC SPINAL CORD INJURY

Contacts and locations

Locations

James J. Peters VA Medical Center
RECRUITING

The Bronx, New York, 10468, United States
Kessler Institute for Rehabilitation
NOT_YET_RECRUITING

West Orange, New Jersey, 07052, United States
Northwell Health
RECRUITING

Manhasset, New York, 11030, United States

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