Nervous system injury

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This early study tests whether implanting electrodes deep in the brain (thalamus) can safely help people with long-term disorders of consciousness. Only 2 participants will be enrolled, and the main goal is to check safety and see if awareness improves using a standard behavioral…

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This trial investigates the safest time to restart direct oral anticoagulants (DOACs) after a traumatic brain bleed. Many older adults who fall and hit their head are on blood thinners for conditions like atrial fibrillation, and stopping them raises the risk of stroke or clots. …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests an implanted spinal cord stimulator (ARC-IM System) to help people with chronic spinal cord injury manage dangerously low blood pressure and fainting. Sixty participants will receive the implant and be randomly assigned to active or sham stimulation for 3 months,…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This study tests hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—for people with severe traumatic brain injury. Researchers will compare different oxygen pressures to see which works best. The goal is to improve long-term recovery and reduce brain swellin…

This early study tests whether a daily supplement called gamma-glutamylcysteine (GGC) can boost the brain's natural antioxidant levels in people who have had repeated head impacts, such as retired NFL players and military veterans. The 30 participants will take GGC tablets for a …

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests whether a drug called 4-AP, taken twice daily, can boost recovery of leg movement in people with spinal cord injury. Participants also receive a type of brain stimulation and leg training. The goal is to improve walking and muscle strength. The study involves 27 …

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This study tests two non-invasive therapies to help people with chronic cervical spinal cord injury regain arm and hand function. Ten participants will try both therapies, each for two months, combined with rehabilitation. The goal is to see which works best and tailor treatments…

This study tests a device that sends electrical pulses to the spinal cord, combined with daily rehab, to help people with chronic spinal cord injury regain walking ability. Twelve participants will receive the implant and be followed for over a year. The goal is to see if the app…

This study tests whether combining cognitive training with brain stimulation (rTMS or tDCS) can improve thinking skills in veterans who have persistent symptoms after mild traumatic brain injury. Participants will receive 16 sessions of training with either real or sham stimulati…

This study is testing a wireless brain implant that lets people with severe spinal cord injuries control external devices just by thinking. The device is placed in the brain with a small surgery. Researchers will check how well participants can perform tasks using only their brai…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This expanded access study offers stem cell therapy (HB-adMSCs) to up to 8 people with traumatic or non-traumatic brain injury who were not eligible for a related trial. Participants receive 6 intravenous infusions over 16 weeks. The goal is to evaluate safety and whether the tre…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study looks at whether having surgery sooner or later after a traumatic spinal cord injury leads to better recovery. Researchers will compare how much nerve function improves in 100 adults who get either early or delayed surgery. The goal is to find the best timing to help p…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests whether vitamin D3 supplements can reduce inflammation and improve recovery in adults with mild-to-moderate traumatic brain injury. Researchers will give different doses of vitamin D3 or a placebo to 240 participants and track their blood markers and neurological…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study tests a device that stimulates a nerve in the leg to help people with spinal cord injury manage their bladder function at home. About 21 adults with chronic spinal cord injury (at level T9 or above) will use the device and be monitored for safety, reliability, and ease…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This early study tests a device called Mechanical Tissue Resuscitation (MTR) that is designed to drain excess fluid from the brain area after a person has had part of their skull removed or repaired. The trial will include 11 people who need a drain as part of their standard care…

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of b…

This study tests whether an implanted device that sends electrical pulses to the spinal cord can improve movement and feeling in people with chronic spinal cord injuries. Ten participants with injuries above the T10 level will receive the implant and undergo regular assessments o…

This study compares two common seizure medications, levetiracetam and lacosamide, to see which works better at preventing early seizures after a traumatic brain injury. Researchers will also track side effects like agitation and sedation. The trial plans to enroll 600 adults with…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This early study is testing a device called ARC-IM Therapy, which delivers electrical impulses to the lower spinal cord, to see if it can help people with spinal cord injury regain the ability to walk. The trial will include 12 adults with recent or long-term injuries. The main g…

This early-stage trial tests whether draining fluid from the spine (external lumbar drainage) is safe and doable for people with severe traumatic brain injury who have high pressure inside the skull. Thirty adults aged 18-65 will receive either standard care alone or standard car…

This study tests whether functional electrical stimulation (FES) can improve arm and hand function in people with spinal cord or peripheral nerve injuries. Researchers will use the MyndMove device to stimulate muscles during short therapy sessions. The goal is to see if this appr…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding in the brain. About 100 adults will receive the drug or a placebo within 24 hours of injury. The main goal is to see if …

This study tests whether a non-invasive nerve stimulation on the leg, called transcutaneous tibial nerve stimulation (TTNS), can help maintain bladder function in people with recent spinal cord injury. Researchers will enroll 120 adults with spinal injuries at level T9 or above, …

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study tests whether semaglutide (Ozempic), a drug used for type 2 diabetes, works well for people with spinal cord injury (SCI) who also have diabetes. SCI patients are at higher risk for diabetes, but it's unclear if standard treatments are effective. The trial will measure…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests whether a spinal cord stimulator — a device that sends mild electrical pulses to the spinal cord — can help people with long-term bladder and bowel problems after a spinal cord injury. Ten adults with injuries older than 6 months will have the device implanted an…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study tests whether an implanted spinal cord stimulator can improve autonomic functions like blood pressure and heart rate in people with chronic cervical spinal cord injury. The device delivers electrical pulses to the spinal cord to help regulate involuntary body processes…

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several ti…

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve nerve recovery. About 102 adults with recent spinal cord injuries will take part. The goal is to see if…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study combines non-invasive electrical stimulation of the spinal cord with treadmill step training to help people with incomplete spinal cord injury improve walking, posture, and bladder, bowel, and sexual function. About 36 participants will receive stimulation alone or wit…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This Phase 3 trial tests whether a single injection of tranexamic acid, given within 3 hours of a mild head injury, can reduce brain bleeding, disability, and death in adults aged 50 and older. The study aims to enroll 5,000 participants and compares the drug to a placebo. If suc…

This early study tests a device called the Bidirectional Neural Bypass System in up to 7 people with tetraplegia (paralysis from the neck down). The device is designed to let users move and feel their hand and wrist again by bypassing the damaged spinal cord. Researchers will mea…

This study looks at whether nerve transfer surgery can improve arm function and quality of life in people with high-level cervical spinal cord injuries (tetraplegia). Thirty participants will receive standard nerve transfer surgery and be followed for up to 4 years. The goal is t…

This study is testing a robotic exoskeleton called TWIICE Rise to see if it is safe and practical for people with spinal cord injury to use for walking. The trial involves 15 participants and will take place in clinics, homes, and community settings. The goal is to assess how wel…

This study tests whether a 'cafe therapy' program helps people with chronic traumatic brain injury improve their movement, thinking, and daily function. Twenty participants will work in a real cafe for 2 hours a day, 3 days a week, for 6-8 weeks, with supervision from researchers…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, and sexual function in people with spinal cord injury. About 60 veterans and adults in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab…

This pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training (RGT) can improve trunk control and walking in people with chronic spinal cord injury. Twelve participants will first receive RGT alone, then RGT plus tSCS, and their prog…

This study tests a personalized stepwise treatment for teens aged 12-16 with mild to moderate scoliosis (spine curve under 45 degrees). It compares two types of electroacupuncture and checks if a simpler screening method can replace X-rays. The goal is to improve spine curvature …

This study is testing a small device called KeyGrip that is implanted in the arm to help people with cervical spinal cord injury regain hand function. The device uses mild electrical pulses to activate paralyzed muscles, allowing hand opening and closing. Researchers will measure…

This study tests a new device called SSMD to help people with arm weakness after a stroke or traumatic brain injury. About 150 adults will use the device in supervised sessions over 5-6 weeks. The goal is to see if it improves arm movement better than standard electrical stimulat…

This early study tests whether a common diabetes pill, glyburide, can safely protect the spinal cord from further damage after a traumatic injury. Researchers will enroll 12 adults with acute spinal cord injury to check safety and see if the drug helps preserve nerve function. Th…

This early-stage trial tests a new device designed to deliver OPC1 cells directly into the spinal cord of people with traumatic spinal cord injuries. The study will enroll 10 participants with either recent or chronic injuries. The main goal is to see if the device and injection …

This study is testing whether giving fresh frozen plasma (FFP) to people with moderate to severe traumatic brain injury can improve their recovery. About 357 adults aged 18-65 will be randomly assigned to receive either standard care alone or standard care plus two units of FFP. …

This study is checking how well a device called the GORE® TAG® Thoracic Branch Endoprosthesis works for people with a thoracic aortic aneurysm, dissection, or injury. About 200 patients in Japan who receive this stent graft will be followed to see if it is safe and effective. The…

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study is testing a personal exoskeleton that lets people with spinal cord injury walk hands-free and stay balanced on their own. Twelve participants with injuries at or above the T6 level will train with the device over several sessions. The goal is to see if the exoskeleton…

This study tests a hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk and perform everyday activities. The trial will enroll 24 participants who will train with the device over several sessions. Researchers will measure how quickly they ca…

This study tests whether a wearable robotic exoskeleton helps people with recent spinal cord injury regain walking ability better than standard physical therapy. Eighty participants will be randomly assigned to either robot-assisted or conventional gait training for 8 weeks. Rese…

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compa…

This study is for adults over 21 with chronic spinal cord injury (more than a year) who have lost motor function. Researchers will implant a spinal cord stimulator and combine it with advanced robotic rehabilitation to see if it can improve movement, like walking. The main goal i…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This study looks at how well a spine implant (VIPER PRIME/Expedium) combined with a special bone graft putty (Fibergraft BG) helps bones fuse together after spine surgery. About 100 adults with spine problems like slipped vertebrae or disc degeneration will be followed for two ye…

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This study looks at how well a special intensive therapy called ACQUIRE Therapy works for children with motor problems caused by conditions like cerebral palsy, autism, or brain injury. The therapy involves many hours of play-based exercises each day, often with a cast or splint …

This study tests whether a special egg yolk powder called Salovum can help people with severe traumatic brain injury. Half of the 20 participants get Salovum, the other half get a placebo. Researchers will measure brain pressure, oxygen levels, and inflammation to see if the trea…

This study tests whether a non-invasive device that sends small electrical pulses to the spine, combined with repetitive hand and arm exercises, can improve movement in people with chronic tetraplegia from a cervical spinal cord injury. Researchers will measure changes in muscle …

This early study tests the safety and function of a brain-computer interface (BCI) implanted by a robot in people with severe paralysis. The device aims to let users control external devices like computers or phones using their thoughts. The trial enrolls 15 adults with quadriple…

This study tests whether a combination of a wearable robot suit, electrical spinal stimulation, and muscle-strengthening exercises can help people with complete spinal cord injury walk on their own. Twenty adults with paralysis from the chest down will train for months to see if …

This study tests whether giving tranexamic acid early after a traumatic brain injury can reduce harmful inflammation. Researchers will enroll 60 adults with mild or moderate head injuries. The goal is to see if this drug can help control the body's inflammatory response and impro…

This early-stage study tests whether a harmless bacterium called Lactobacillus crispatus, when placed directly into the bladder, is safe and can help prevent urinary tract infections (UTIs) in adults with spinal cord injury who use a catheter. Forty participants will receive two …

This study tests a new rehabilitation program for people with recent spinal cord injuries (within 1-5 months). Participants walk on a downhill treadmill while receiving electrical stimulation to their leg and trunk muscles. The goal is to improve walking and movement. Researchers…

This trial tests a device implanted in the arm that stimulates paralyzed muscles to help people with cervical spinal cord injury pick up and release objects. The study involves 13 participants and focuses on safety and how well the device improves hand function. It is an early-st…

This study tests a fully implanted neuroprosthetic device designed to improve hand, reach, and trunk function in people with cervical spinal cord injuries. Thirty participants will receive the device and be evaluated on their ability to perform daily activities with and without i…

This study tests a new spinal implant system (ARC-IM Lumbar) in 8 people with chronic spinal cord injury who already have a spinal implant. The goal is to improve walking, bladder, bowel, and sexual function, and make the system easier to use at home. Participants will be followe…

This study tests two surgical procedures to reduce further damage after a severe spinal cord injury. Ten adults with recent spinal cord injury will receive either a standard decompression surgery or that surgery plus a nerve graft. The goal is to see if these approaches are safe …

This Phase 2 trial tests whether sildenafil citrate (the drug in Viagra) can improve blood vessel function in the brain of people who had a traumatic brain injury (TBI) at least 6 months ago. Researchers will give different doses (20, 40, or 80 mg) or a placebo to 160 adults aged…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study aims to create a blood test that helps doctors quickly diagnose traumatic brain injury (TBI) and predict how patients will recover. Researchers will collect blood samples from 2,000 adults with suspected TBI in emergency rooms and hospitals. The goal is to find specifi…

This study tests whether a very powerful 7 Tesla MRI can detect tiny brain injuries in people with post-concussion syndrome after a mild head trauma. Researchers will scan 100 patients one week after their injury and compare the results to standard tests. The goal is to see if th…

This study is testing a new device that scans the eyes to find signs of mild traumatic brain injury (TBI). The device looks at how the eyes move and focus, which can be affected by a brain injury. Researchers will scan 60 people with a recent head injury and 20 healthy volunteers…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study is testing whether a simple saliva test can help detect concussions in professional rugby players. Researchers will measure specific proteins and genetic material in saliva before and after matches, and compare them with impact data from special mouthguards. The goal i…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study is testing a new device called Crainio that uses infrared light to measure pressure inside the skull without needing to insert a probe into the brain. Researchers will enroll 54 adults with traumatic brain injury who already require standard invasive monitoring. The go…

This study is working on a new way to diagnose concussions in athletes using a simple saliva test. Researchers will measure specific molecules in the saliva of 80 male athletes (professional, amateur, and occasional) before, during, and after exercise. The goal is to find reliabl…

This study is testing a new, 10-minute MRI sequence (3D FGAPSIR) to see if it can find more spinal cord lesions in people with multiple sclerosis than standard scans. Researchers will enroll 200 adults already scheduled for a spinal MRI. The goal is to improve detection of spinal…

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study looks at whether a blood test measuring two brain injury markers can safely rule out the need for a CT scan in people with mild traumatic brain injury. Researchers will compare a new management pathway using this test to standard care in 1,000 emergency room patients. …

This study looks at whether a simple blood test can help doctors decide if a head CT scan is really needed after a mild head injury. Researchers will collect blood samples from 350 adults with mild head trauma and see if the test results match the need for imaging. The goal is to…

This study tests a smartphone app designed to help people who use wheelchairs or scooters prevent and manage falls. Researchers will compare the app to standard fall prevention information in 120 adults with spinal cord injury or multiple sclerosis. The goal is to see which appro…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study tests whether a short form of exposure therapy, given soon after a traumatic injury, can prevent posttraumatic stress disorder (PTSD). Researchers will enroll 300 injured adults admitted to Level I trauma centers. Half will receive the brief therapy plus standard care,…

This study tests whether gentle electrical stimulation of nerves in the leg or lower back can prevent the bladder from becoming overactive after a spinal cord injury. Researchers will compare two types of nerve stimulation against standard care in 45 adults who had a spinal injur…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study tests three approaches—oxygen therapy, the drug trazodone, and brief low-oxygen episodes—to see if they can improve sleep apnea in people with chronic cervical spinal cord injury. Researchers will measure changes in breathing and sleep quality in 100 participants. The …

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether early, symptom-guided therapy can prevent long-term complaints after mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, psychoeducation by phone, or usual care. The goal is to reduce post-concussion…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study tests a smartwatch-based system that gives real-time tips and reminders to help people with spinal cord injury increase their physical activity. About 196 adults who use wheelchairs will be split into two groups: one gets a standard web-based exercise program, and the …

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests whether taking creatine supplements after a concussion helps people recover faster. Twenty adults aged 18–35 with a recent concussion will either take creatine or follow their usual diet. Researchers will track how many days it takes to become symptom-free and co…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This pilot study tests whether combining a gentle nerve stimulator placed on the ear (taVNS) with robotic tilt-table therapy can safely help people with prolonged disorders of consciousness after severe brain injury. Fifteen participants will undergo 12 weeks of paired therapy, a…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study compares two remote training programs for 300 people who have had a mild traumatic brain injury (concussion) and struggle with emotional awareness and regulation. One program teaches participants to recognize and label their emotions, while the other focuses on general…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study tests whether deep brain stimulation (DBS) can improve walking in people with incomplete spinal cord injury. Six adults who have had a spinal injury for at least one year will receive DBS to a brain area called the cuneiform nucleus. The goal is to see if it safely hel…

This study tests whether a low-volume nose resistance breathing exercise using an Acapella device plus an incentive spirometer can improve lung function and reduce shortness of breath, cough, and phlegm in people with cervical spinal cord injuries. Forty-two inpatients aged 18–38…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a traumatic spinal cord injury, is safe and might help patients recover movement. Fifteen adults with acute spinal cord injury will receive either real or sham sti…

This study tests a live, group tele-exercise program (TEEMS) for people with spinal cord injury. Researchers want to see if it improves exercise confidence, physical activity, and quality of life compared to watching pre-recorded exercise videos. The program is fully virtual to m…

This pilot study is testing whether a home-based virtual reality exercise program called VR-Move can improve fitness and quality of life in people with spinal cord injuries. Sixteen participants will use the VR system three times a week for 12 weeks. The goal is to provide an acc…

This study is testing a wearable robotic exoskeleton called ABLE Daily to see if it is safe and works well for helping people with spinal cord injury walk in their home and community. Ten participants will train with the device at a clinic for three weeks, then use it on their ow…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests two different therapies to help people with ongoing memory problems after a concussion. One is traditional cognitive rehabilitation, and the other is a new cognitive-behavioral therapy (CBT) approach. Researchers want to see which one works better for improving h…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests whether daily training with colored lights can reduce light sensitivity in people who have had a traumatic brain injury. Twenty participants will use a device at home for 20 minutes a day, first with a blue light and then with a red light, or vice versa. Research…

This study tests whether daily symptom tracking via smartphone can help teens with concussion get quicker access to specialty care. About 210 teens aged 13-18 who visit the emergency department with a concussion and are at high risk for long-term symptoms will report their sympto…

This study tests whether a week of accelerated brain stimulation (25 sessions over 5 days) can quickly reduce PTSD symptoms. It involves 132 adults with PTSD, including those with traumatic brain injury. The goal is to see if this fast-paced treatment works better than a placebo …

This study tests whether community health workers can help caregivers of people with traumatic brain injury (TBI) during the move from rehab to home. About 126 adult caregivers will get either standard support or extra help from a health worker starting before discharge. The goal…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study tests whether a smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. About 50 participants will use either a basic or interactive app, and those who struggle may get extra coaching. The goal is to find the best way to boos…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study tests whether a 12-week pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Thirty participants will do exercises five times a week. Researchers will track how many people join, stick with the program, and …

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers wi…

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study is testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and daily function in 15 people with mild traumatic brain injury (mTBI) who have trouble sleeping. Participants will learn techniques like sleep scheduling and changing unhelpful tho…

This pilot study is testing a special capsule that vibrates as it moves through the digestive system. The goal is to see if it is safe and helpful for people with spinal cord injuries who have bowel problems. Only 12 participants will be enrolled to check safety and how well they…

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests whether a semi-elemental liquid diet (a pre-digested formula) reduces stomach and bowel issues like vomiting, diarrhea, and bloating in patients with severe traumatic brain injury. About 100 adults will receive either the special formula or standard liquid nutrit…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…

This study tests whether practicing driving skills in a simulator can improve real driving performance in veteran stroke survivors. One hundred participants will complete both active training (focusing on speed, lane position, collision avoidance, and attention) and a control ses…

This study tests whether a noninvasive brain stimulation method, combined with hand exercises, can improve grasping ability in people with chronic spinal cord injury. About 54 adults with neck-level injuries will receive either real or sham stimulation during training sessions. T…

This study tests a new approach that combines magnetic brain stimulation, electrical spinal cord stimulation, and muscle stimulation to improve hand, leg, and trunk function in people with spinal cord injury. Researchers will enroll 25 participants, including both injured and abl…

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests a new multi-speed ergonomic wheelchair designed to reduce shoulder overuse injuries common in manual wheelchair users. Thirty adults who use a manual wheelchair daily will try different gear ratios on various surfaces. The goal is to see if the design improves pr…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study tests a portable virtual reality system that guides eye exercises to help veterans with mild traumatic brain injury improve their eye coordination. About 80 veterans will be split into two groups: one receiving active therapy and the other a sham version. The goal is t…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

This study looks at whether pelvic floor muscle training is practical and helpful for people recovering from a spinal cord injury during inpatient rehab. Researchers will recruit 50 participants to do pelvic floor physiotherapy five times a week for six weeks. The goal is to see …

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical (neck) spinal cord injury regain arm and hand function. The device, called the CoverEdgeX 32 Surgical Lead, is already approved for pain but is investigational f…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study tests a counseling program for caregivers of children hospitalized for a traumatic injury like burns or a car accident. The goal is to reduce PTSD and depression in both the caregiver and child. 24 caregiver-child pairs will be randomly assigned to either the counselin…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study tests whether goal-oriented cognitive training delivered via video calls can help veterans with mild to moderate traumatic brain injury (TBI) improve attention, planning, and daily functioning. 80 veterans with lasting cognitive difficulties will participate remotely. …

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests whether a brief behavioral treatment for insomnia (BBTi) — guided by a nurse or through a mobile app — can improve sleep, mood, and thinking in people recovering from traumatic brain injury (TBI). About 93 participants with chronic TBI and insomnia will be assign…

This study tests whether non-invasive spinal stimulation, used at home with exercise, can safely improve arm and hand function in people with recent cervical spinal cord injury. 46 participants will be randomly assigned to start the program immediately or after a 12-week delay. T…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether using mild electrical pulses on the belly muscles during a bowel program can cut down the time it takes. Fifteen adults with chronic spinal cord injury (above T11) will try the device at home and track their bowel routine times, quality of life, and any c…

This pilot study tests whether focused shockwave therapy can safely reduce arm spasticity in people with spinal cord injury. Twelve participants will receive three weekly sessions of sound waves applied to the forearm and elbow muscles. Researchers will measure changes in muscle …

This study looks at whether using special prismatic lenses along with computer brain games can help improve thinking and behavior in people who have had a traumatic brain injury. About 50 adults will take part, with half getting the lenses plus games and the other half getting ga…

This study tests whether a single dose of ketamine given during surgery can help adults with serious orthopedic trauma recover better. Researchers want to see if it reduces pain, lowers the need for opioids, and improves symptoms of depression and PTSD. Ninety participants will b…

This early-stage study is checking if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will monitor side effects and see if virtual training…

This study tests whether breathing low oxygen, along with spinal cord stimulation and walking practice, can improve walking for people with chronic spinal cord injury. About 60 adults with some walking ability will take part. The goal is to see if these combined treatments can he…

This study is for adults aged 18–80 with chronic spinal cord injury who can already walk a little. It combines short periods of breathing low oxygen, spinal cord stimulation, and walking practice to see if it helps them walk better. The goal is to improve walking speed and endura…

This study tests a nerve block procedure called bilateral cervical sympathetic block (BCSB) in 75 Special Operations Veterans with PTSD, anxiety, or traumatic brain injury. The procedure uses a numbing medicine to calm overactive nerves. Some participants also receive talk therap…

This study tests a brain implant that lets people with severe paralysis control a tablet computer using only their thoughts. The goal is to help them communicate, use apps, and control smart devices, improving their quality of life. Up to 5 participants will be implanted and foll…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can improve thinking and memory in people still having symptoms 3 to 12 months after a mild concussion. Thirty adults will receive 10 sessions over about 3 w…

This study is testing a small, wearable device that sends a barely noticeable electrical current behind the ears to see if it can improve balance and walking in people still struggling with dizziness weeks after a concussion. About 32 adults aged 18 to 55 with persistent symptoms…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with breathing exercises, can improve lung function in people with chronic spinal cord injury. About 36 adults will be split into three groups: breathing training alone, stimulation alone, or bo…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether a spinal cord stimulator, combined with breathing exercises, can improve respiratory function in people with chronic spinal cord injury. Thirty adults with neck-level injuries will undergo 16 weeks of training while using the device. Researchers will meas…

This study tests a virtual cognitive rehabilitation program designed for refugees and asylum seekers who have had a traumatic brain injury (TBI) and struggle with thinking and memory. The program includes 8 virtual sessions led by trained bilingual staff, covering brain injury ed…

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Sixty adults will receive either real or sham rTMS daily for 15 sessions while continuing their usual pain medications. Pain levels will be mea…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) for depression in people with spinal cord injury. Fourteen adults with a spinal cord injury and major depression will receive daily rTMS sessions for four weeks. The go…

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

This study is testing whether a slow, resistive yogic breathing technique called Ujjayi can improve breathing, lung function, and sleep in people with spinal cord injuries. Twenty adults aged 18 to 60 who use wheelchairs will practice Ujjayi breathing for six weeks. Before and af…

This study tests whether a gentle electrical current applied to the skin over the spinal cord (called transcutaneous spinal cord stimulation) can safely improve walking in children aged 3 to 16 with incomplete spinal cord injury. Twenty children will receive either real stimulati…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…

This study is testing a wearable robotic hand orthosis called MyHand-SCI for people with C6-C7 spinal cord injury. The device is designed to assist with hand and finger movement. Researchers will enroll 40 participants to evaluate how usable and helpful the device is. The goal is…

This study tests a structured rehabilitation program for active-duty soldiers who have had a mild traumatic brain injury (concussion). The program includes low-intensity aerobic exercise, balance, and cognitive activities tailored to each soldier's symptoms and job demands. Resea…

This study is testing a wearable robotic exoskeleton that stretches the legs of people with spasticity caused by spinal cord injury. The device aims to mimic the stretching done by nurses or caregivers. Ten veterans will try the device during leg stretching, treadmill walking, an…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study tests whether virtual reality exercises can reduce neck pain and disability better than standard physical therapy. Seventy-two adults with chronic neck pain or whiplash will do 12 sessions over six weeks. Half will use VR, the other half will do the same exercises with…

This small pilot study tests whether adding a gentle electrical stimulation to the spinal cord (tSCS) can make robotic arm training more effective for people with chronic tetraplegia from a spinal cord injury. Six to eight adults with neck-level injuries will first receive roboti…

This study tests whether magnetic pulses to the brain (TMS) can ease nerve pain that won't go away with standard drugs in people with spinal cord injury. 39 adults with pain for at least 6 months will receive either real or sham TMS to the motor cortex or the anterior cingulate c…

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce PTSD symptoms and improve thinking problems in people with PTSD, including those who also have a mild traumatic brain injury. 120 participants will receive either a low or high dose of CBD or a place…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests a guided online version of cognitive behavioral therapy for insomnia in 80 people who have had a moderate or severe traumatic brain injury at least a year ago and currently have insomnia. Participants will either receive the online therapy (6 modules over 6-9 wee…

This study tests whether electromagnetic stimulation can safely improve bladder function in people with spinal cord injury. Researchers will enroll 24 men with complete motor paralysis who have used catheters for at least a year. Participants will receive non-invasive stimulation…

This study looks at whether a robotic walking trainer, called Trexo, can help people with walking problems from conditions like cerebral palsy or brain injury. About 120 participants will use the robot in a hospital setting to see if it's practical and helps them reach their pers…

This study is testing a personal exoskeleton that helps people with spinal cord injury stand, walk, and move without using their hands. The device is self-balancing, so users don't need crutches or a walker. Researchers will see if 24 participants can complete walking tests and e…

This study tests whether a gentle brain stimulation technique called tDCS can improve motor and thinking skills in children aged 10-15 who have had a mild concussion. Ten participants will receive tDCS and be evaluated with balance, coordination, and brain imaging tests. The goal…

This study tests a noninvasive treatment called REAC that uses gentle electrical signals to help rebalance brain activity after a severe traumatic brain injury. Researchers will compare real REAC sessions to a sham (fake) version in 60 patients to see if it improves brain wave pa…

This study tests an 8-week online program called MENTOR that teaches mindfulness, exercise, and nutrition to people who had a traumatic brain injury at least a year ago. Researchers want to see if it improves emotional health, physical activity, and overall well-being. The trial …

This study tests whether a virtual walking therapy can reduce chronic nerve pain in people with spinal cord injury. Participants will watch a life-sized video of themselves walking through a forest while seated in a tilting wheelchair. The trial will enroll 40 adults and compare …

This study is testing a non-invasive device called PNRT that uses gentle light and motion to help people with lingering dizziness and other symptoms after a mild traumatic brain injury. Researchers will enroll 80 adults to see if the device is safe, tolerable, and can reduce dizz…

This study tests whether starting personalized aerobic exercise soon after a concussion helps active-duty military members recover faster and avoid long-term symptoms. About 168 participants will either do daily exercise plus standard care or standard care alone. The goal is to s…

This study is testing whether adding a mild electrical stimulation to the lower back can boost the benefits of a robotic exoskeleton for people with chronic spinal cord injury. Twenty-four participants who cannot walk will receive either exoskeleton training alone or combined wit…

This study tests whether shining a special light on the forehead (transcranial photobiomodulation) can improve blood flow and thinking in older adults who had a traumatic brain injury 1-2 years ago. Seventy people aged 55-85 will receive either real or sham light therapy for abou…

This study is for people with spinal cord injury who also have depression. It tests a new method to dose a brain stimulation treatment called rTMS, which is already approved for depression but usually requires a thumb movement to set the dose. Since many with spinal cord injury h…

This study tests a new rehab approach for people with incomplete spinal cord injury. It combines electrical muscle stimulation with augmented reality games during walking exercises. 70 adults aged 18-45 will be split into two groups: one gets the high-tech training, the other get…

This study tests a bilingual program called 1stBIEN for Hispanic children (ages 3-17) recovering from traumatic brain injury. The program provides in-person education, mobile videos, and a navigator to help families access outpatient care and school support. Researchers will meas…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with computer-based brain games can improve attention, memory, and decision-making in veterans aged 65 and older who have had a mild traumatic brain injury. Participants will do exercises from home …

This study tests a new rehab program called STAR-C for people with lasting cognitive issues after a mild traumatic brain injury (concussion). It compares three groups: in-person therapy, online therapy via telehealth, and a waitlist that gets no treatment. The goal is to see if S…

This study compares two types of talk therapy for insomnia in 160 active-duty military members who have had a mild traumatic brain injury and still have symptoms like trouble sleeping, thinking, or mood issues. One therapy is longer (6 sessions) and the other is shorter (4 sessio…

This study tests whether a 10-week online expressive writing program can help adults with spinal cord injury work through feelings of grief and loss. Participants will write about their emotions with guidance from a coach and share reflections with others. The goal is to see if t…

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The training combines exercises to recognize emotions in faces and voices with attention training, since paying attention is key to understanding emotions in daily life…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This small early-stage study tests whether a device that combines augmented reality (AR) with functional electrical stimulation (FES) is safe and usable for people with cervical spinal cord injury. Seven participants will attend 20 one-hour sessions over 10 weeks, using the syste…

This study looks at whether a common dietary fiber called inulin can improve fatigue and thinking problems in people recovering from brain injuries. Researchers will give inulin to 130 adults in neurorehabilitation and track changes in their gut bacteria and symptoms. The goal is…

This study tests whether combining a powered exoskeleton (a robotic leg brace) with functional electrical stimulation (small muscle zaps) can improve walking speed in people with chronic spinal cord injury. About 34 participants with incomplete injuries will be randomly assigned …

This study tests whether a mobile app can help adults with dizziness after a mild traumatic brain injury. 68 participants will either do standard home exercises or use a gamified app version. The goal is to see if the app leads to greater improvement in dizziness and balance afte…

This study tests whether playing a virtual reality walking game at home can help reduce neuropathic pain in adults with chronic spinal cord injury. 250 participants with complete injuries will use a VR headset to see virtual legs walking from a first-person view. They will play t…

This pilot study tests whether a neurofeedback device can reduce light sensitivity in 36 Veterans who have had a mild traumatic brain injury at least 6 months ago. The device uses low-intensity electrical pulses to train brain activity. Researchers will also use MRI scans to see …

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether combining non-invasive spinal cord stimulation with walking rehabilitation can reduce muscle stiffness and improve leg strength and walking ability in people with incomplete spinal cord injury. Ten adults with stable, incomplete spinal cord injury who can…

This study tests whether sildenafil (the drug in Revatio, similar to Viagra) can reduce urine leakage in people with spinal cord injuries. Twenty-four adults who have at least three leaks per week will take either sildenafil or a placebo for four weeks. Researchers will track how…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

This study tests whether adding gentle electrical stimulation to physical therapy can help people who have had a severe stroke and developed muscle weakness in the ICU. About 24 participants will receive either standard therapy or therapy combined with functional electrical stimu…

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. About 18 adults with cervical-level injuries will receive either real or sham stimulati…

This study tests a web-based program called webSTAIR, which teaches emotion regulation and relationship skills, for female veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see if it helps them manage em…

This study tests whether a non-invasive spinal cord stimulation device can improve autonomic functions like blood pressure, bladder, bowel, and sexual control in people with chronic spinal cord injury. Thirty participants will receive targeted stimulation over several weeks. The …

This study looks at whether Xeomin injections can reduce migraine pain and frequency in people who have had a traumatic brain injury or an unexplained health incident. About 60 adults will receive the injections and report their headache changes over 12 weeks. The goal is to see …

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study looks at how blood pressure changes in the first year after a spinal cord injury and whether a device that stimulates the spine through the skin can help. Five people with recent injuries will be followed for a year, testing the stimulation during sessions to see if it…

This study looks at whether two different training programs can improve emotional health in people who have had a moderate to severe traumatic brain injury. About 48 adults will take part in 8 one-on-one sessions over a month, learning either to recognize emotions or adopt health…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing diffe…

This study compares brain health in 300 former professional football players (ages 29-59) to a similar group of men who did not play football. Participants will undergo cognitive tests, balance and eye-movement exams, sleep assessments, and high-resolution MRI scans. The goal is …

This study looks at 200 children with minor head trauma to see if family education, income, and health literacy influence parents asking for a CT scan. Doctors already have a rule (PECARN) to decide when a CT is needed, but parents sometimes request one anyway. The goal is to und…

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at whether giving older trauma patients extra protein drinks (up to 3 times a day in the hospital and for 4 weeks after discharge) helps them regain muscle and function better than standard nutrition. Sixty adults aged 45 and older who can eat by mouth will be ra…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study is testing whether a robotic ultrasound device can safely and effectively monitor blood flow in the brains of people with severe traumatic brain injury. The device is designed to work automatically for long periods, even in hospitals with little ultrasound experience. …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study from Mayo Clinic looks at how the body manages blood pressure after a spinal cord injury and whether those changes can predict future health problems. Researchers will test 18 people with spinal cord injuries (either recent or long-term) using simple procedures like co…

This Mayo Clinic study is looking at how spinal cord stimulation affects blood pressure, heart rate, and immune function in people with spinal cord injuries. Researchers will test how the body handles changes in blood pressure using simple tasks like hand cold pressor tests and b…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study looks at how adults with acquired brain injury (like from stroke or trauma) learn connections between things without being directly taught. Researchers will test 40 participants using a task that links pill shapes, functions, and names. The goal is to understand how br…

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study looks at how doctors decide to use brain CT scans for people with mild head injuries in emergency rooms. Many CT scans come back normal, exposing patients to unnecessary radiation and increasing costs. Researchers will analyze data from 2,500 adults across Italy to und…

This study looks at whether a breathing technique called acute intermittent hypoxia (AIH) increases spasticity (muscle tightness) in people with chronic spinal cord injury. Ten adults with incomplete spinal cord injury will receive AIH and have their reflexes and muscle stiffness…

This study looks at why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks in 300 participants to understand the underlying causes. The goal is to better classify pain types, not to test a new trea…

This study follows 100 adults who had surgery for traumatic nerve injuries in the hand or arm. Researchers will measure hand function, strength, and quality of life over time to better understand long-term recovery. The goal is to gather information, not to test a new treatment.

This study will video-record occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to understand exactly what therapists do to help patients improve arm and hand movement. The goal is to create a toolkit that makes rehabilitation …

This study is testing whether a non-invasive brain stimulation technique called iTBS, combined with computer-based attention training, can improve focus and daily functioning in people with persistent attention problems after a mild traumatic brain injury (mTBI), with or without …

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study tests whether mild electrical stimulation of a nerve in the forehead can improve blood flow and waste clearance in the brain. Researchers will measure changes in brain fluid flow using MRI and light-based imaging in 55 healthy adults and people with mild traumatic brai…

This study tests a new computer system called SeeMe that can detect tiny movements in people with severe traumatic brain injury (TBI). Current exams may miss these movements, leading to misdiagnosis. The study will involve 60-80 TBI patients and aims to see if SeeMe can find sign…

This study is developing a standard test to measure how well assistive technologies (like eye trackers) and brain-computer interfaces help people with spinal cord injury or ALS use computers and phones. Researchers will test 60 participants, including healthy volunteers and peopl…

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study is looking at whether measuring two proteins in the blood (NF-L and GFAP) soon after a spinal cord injury can help doctors predict how severe the injury is and how much recovery a person might have 6 months later. Researchers will enroll 260 adults with traumatic spina…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study looks at whether a computer program called BrainHQ can help adults with traumatic brain injury improve their memory and attention. About 150 people with mild to severe brain injuries will either use BrainHQ or play regular brain games. Researchers will test their think…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study looks at how a moderate traumatic brain injury (TBI) from early or middle adulthood might speed up physical and mental decline in older age. Researchers will test balance and thinking in 70 Veterans aged 50-75 who had a TBI at least 15 years ago, even if they feel fine…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to mod…

This study looks at how different meals affect energy use and appetite in men with high spinal cord injury (T6 and above) compared to able-bodied men. Participants will eat standardized meals and have their metabolism measured. The goal is to understand how food impacts cardiovas…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study follows 100 adults who had a traumatic brain injury and completed 60 sessions of hyperbaric oxygen therapy. Researchers will test their thinking, memory, and quality of life 1 to 4 years later to see if improvements stick. The goal is to understand the long-term effect…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This study looks at whether imagining certain movements or scenarios can trigger or worsen headaches and dizziness in people who have had a mild traumatic brain injury or concussion and still have symptoms months later. Researchers will ask 60 adults to imagine movements that usu…

This study looks back at medical records of 4 severely injured trauma patients who needed large blood transfusions. It compares two drugs that help blood clot—prothrombin complex concentrate and recombinant activated factor VIIa—to see which causes fewer dangerous blood clots and…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This small study tests whether combining standing therapy with mild electrical stimulation of a nerve in the leg can improve pelvic floor muscle function in adults with chronic spinal cord injury. Twelve participants will undergo 12 weeks of treatment, three times per week. Resea…

This study looks at how spinal cord stimulation combined with physical training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand if these changes lead to bette…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study looks at adults with serious brain injuries from stroke, trauma, or bleeding who need a breathing machine. Researchers want to see if certain machine settings are linked to how severe the brain injury is. About 19 people will take part, and no new treatments are being …

This study compares two types of spinal stimulation—transcutaneous (through the skin) and epidural (implanted via surgery)—to see how they help people with spinal cord injury generate leg force and stand with support. Sixty adults aged 22-75 who cannot stand independently will pa…

This study looks at whether a noninvasive device that stimulates the vagus nerve can improve the ability to understand speech in noisy environments for people who have had a traumatic brain injury. Researchers will compare brain responses and speech test scores with and without t…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study tests whether breathing low oxygen for short periods (called intermittent hypoxia) can improve walking and strength in people with chronic spinal cord injury. Researchers want to understand how this affects the nervous system. The trial involves 44 participants who wil…

This study tests a new method to personalize TMS (a non-invasive brain stimulation) dosing for people with PTSD, with or without mild traumatic brain injury. Researchers will use brain imaging (fNIRS) to measure brain activity directly, aiming to replace the current indirect meth…

This study looks at how eating a high-fat meal affects pain sensitivity and inflammation in people with chronic spinal cord injury. Researchers will compare a high-fat meal to a moderate-fat meal in 40 adults. They aim to understand links between body composition, diet, and pain.

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage common health problems like pain, bladder issues, and stress. About 40 adults with spinal cord injury will receive texts with tips and support, and researchers will see…

This study looks at two different methods to check consciousness in people with severe brain injuries. The goal is to see if a shorter, simpler test works as well as the longer standard one. About 110 patients will take part, and the results could help doctors make better treatme…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study looks at how heart function relates to recovery in people with severe traumatic brain injury or brain bleeding. Researchers will collect data from routine monitoring and follow up with 50 adults 6 months after hospital discharge. The goal is to better understand the co…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study tests whether a simple procedure called remote ischemic preconditioning (RIPC) — briefly restricting blood flow to an arm or leg — can reduce brain injury after non-cardiac surgery. The trial will include 216 older adults at risk for postoperative delirium. Researchers…

This study looks at how a concussion (mild traumatic brain injury) before age 6 might change brain structure and behavior. Researchers will use MRI scans to compare 30 children who had a concussion with 30 children who had a limb injury. The goal is to better understand the short…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study looks at whether starting body-weight-supported treadmill training (BWSTT) at different times within the first 6 months after a spinal cord injury affects walking ability. 108 participants will be randomly assigned to start therapy within 60 days, 3 months, 6 months, o…

This study is testing whether a special electrode placed deep in the brain can detect abnormal electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury. These waves may cause further damage. The study will involve 15 people who already need…

This study explores whether breathing slightly higher levels of carbon dioxide (CO2) can safely increase the movement of proteins from the brain into the blood, which may indicate better waste clearance. Researchers will compare healthy adults and those with a history of traumati…

This study looks at how focal brain injuries affect mental time travel — the ability to imagine past or future events. Researchers will ask participants to judge whether a person in a photo likely experienced a certain life event years ago or will experience it in the future. The…

This study aims to understand how upper-limb assistive devices—like grasping gloves, mealtime aids, and robotic arms—impact the daily lives of people with motor impairments. Researchers will interview and survey 150 regular users (including those with stroke, spinal cord injury, …

This study looks at whether storing blood for a long time before transfusion affects death rates and complications in severely injured trauma patients. Researchers will review records of 300 patients aged 18-75 who received large transfusions. The goal is to understand if blood s…

This study looks at how small electrical pulses to the brain or arm nerves can help restore sensation in people with spinal cord injuries. Participants already have tiny electrodes implanted as part of a larger study. Researchers will test different stimulation patterns to see wh…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This study is testing a non-surgical method of spinal cord stimulation to help people with spinal cord injury regain movement. Researchers want to see if adjusting the timing and strength of electrical pulses can target specific muscles more precisely. The study involves 48 adult…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study looks at whether a new blood test can help emergency room doctors better assess patients with mild traumatic brain injury (TBI). The test checks for brain injury markers in the blood and may reduce the need for CT scans. Researchers will study how well the test works i…

This study interviews 60 adults with spinal cord injuries and neurogenic bladder, plus their caregivers, to learn about their experiences with different types of bladder washes (gentamicin, lactobacillus, or both). The goal is to understand what they like, dislike, and find helpf…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study uses ultrasound to measure the thickness of ankle cartilage in people with spinal cord injuries and compares it to healthy individuals. The goal is to see if cartilage damage starts early, which could help prevent osteoarthritis. Researchers will also assess participan…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study tests whether using a driving simulator can help adults with acquired brain injury improve their driving comfort, confidence, and independence. Fifty participants will practice with realistic driving scenarios and then take an on-road test. The goal is to see if simula…

This study aims to create a Turkish version of a questionnaire that measures how environmental factors affect people with spinal cord injuries. Researchers will work with experts and adults living with spinal cord injury in Turkey to make sure the questions are clear, relevant, a…

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study looks at whether training physical and occupational therapists in motivational interviewing (a supportive communication style) helps people with spinal cord injuries or disorders engage more actively in their rehab sessions. About 180 patients will take part across thr…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at how fast the bladder is filled during a urodynamic test affects a condition called autonomic dysreflexia (sudden high blood pressure) in people with spinal cord injuries. Researchers will test two different filling speeds in 30 participants to see which one ca…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This early-phase study is testing whether a single dose of ketamine is safe for people with severe traumatic brain injury. Researchers will measure changes in brain pressure and oxygen levels in 10 critically ill adults. The goal is to see if ketamine, which has sedative and pain…

This study tests whether combining non-invasive brain and spinal cord stimulation during a movement task can improve hand function and thinking in people with stroke or spinal cord injury. 45 participants will receive both types of stimulation separately and together to see if th…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This early-phase study looks at how a single dose of intranasal testosterone affects nerve and autonomic function in 15 male veterans with spinal cord injury who have low testosterone. Researchers will measure muscle responses and heart rate changes before and after the dose. The…

This study explores whether using both lung and brain ultrasound can help doctors choose the best ventilator pressure for patients with acute respiratory distress syndrome (ARDS) and acute brain injury. About 30 critically ill adults on breathing machines will be enrolled. The go…

This study uses advanced MRI scans to look at changes in the spinal cord and fluid around it in people with spinal cord injuries. The goal is to see if these changes relate to a person's symptoms and nerve function. Researchers hope this will lead to earlier diagnosis and better …

This study looks at whether monitoring specific brain wave patterns (called spreading depolarizations) in real time can help doctors choose treatments to reduce these events after severe traumatic brain injury. About 72 people who need emergency brain surgery will be randomly ass…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure to pr…

This study is gathering information on how people naturally recover from spinal cord injuries. Researchers will follow 8000 participants across Europe, measuring their independence, movement, and nerve function over time. The goal is to create a detailed baseline of recovery, whi…

This study looks at small molecules in the blood (metabolites) of people with severe traumatic brain injury compared to those with other injuries. Researchers aim to find differences that could help determine how serious a brain injury is and predict recovery. The study involves …

This study uses MRI scans to observe how the brain and spinal cord change after a spinal cord injury. Researchers will compare 450 patients (from recent to long-term injury) with healthy volunteers. The goal is to find imaging markers that can predict recovery and guide rehabilit…

This study will follow 35 people who recently had a spinal cord injury to see how their gut bacteria change over the first year. Researchers will collect blood, stool samples, and bowel function surveys at the start, 6 months, and 12 months. The goal is to understand how the gut …

This study uses advanced MRI scans to see how the brain and spinal cord change after a spinal cord injury. Researchers will study 225 adults with recent or long-term injuries, as well as those with related conditions. The goal is to better understand nerve activity below the inju…

This study is checking how well certain eye tests can measure vision problems caused by mild traumatic brain injury (mTBI). Researchers will test 150 people who had an mTBI within the last 1 to 6 months. The goal is to make these tests reliable for future studies on mTBI-related …

This study looks at whether intensive upper-limb training, started within 13 weeks of a cervical spinal cord injury, can trigger changes in the brain and nerves that improve arm and hand function. Researchers will measure brain activity, nerve signals, and motor skills in 44 part…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…