Can pressurized oxygen heal Veterans' brain injuries? large trial launches

NCT ID NCT06581003

Recruiting now Symptom relief Sponsor: University of South Florida Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can reduce long-term symptoms like headaches, memory problems, and mood changes in veterans with mild to moderate traumatic brain injury. 420 veterans will receive either real HBOT or a placebo (normal air at room pressure) for 40 sessions over 12 weeks. Researchers will track symptom changes and also explore effects on thinking, sleep, and brain scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy (99.7% oxygen at 2.0 ATA pressure)
What this could lead to: If it works, this could provide a new treatment option to ease long-term symptoms like headaches, memory problems, and mood changes after traumatic brain injury.
What could go wrong: This is a large Phase 3 trial, but the placebo group also receives mild pressure and normal air, which may still produce some benefit, making it hard to prove HBOT works. The 40-session commitment may also lead to dropouts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILITARY OPERATIONS TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

University of South Florida
RECRUITING

Tampa, Florida, 33612, United States

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