Nervous system injury

This trial compares three sedatives—propofol, midazolam, and dexmedetomidine—for controlling pressure inside the skull after urgent brain surgery for moderate-to-severe traumatic brain injury. Adults who have had surgery within 24 hours of injury will receive one of the three dru…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This early-stage trial tests whether transplanting a patient's own nose cells into the spinal cord, combined with intensive exercise, is safe and possible for people with chronic spinal cord injury. About 30 participants will receive the cell transplant and a 32-week rehab progra…

This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 p…

This early study tests whether a hormone called hCG (Ovidrel) can help men recover thinking and daily living skills after a moderate to severe traumatic brain injury. Fifty men will receive either the hormone or a placebo twice a week for 24 weeks. The main goal is to check safet…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

This study tests whether a drug called istradefylline can boost the walking improvements seen with low-oxygen therapy in people with chronic, incomplete spinal cord injury. About 40 adults aged 18-75 with injuries at least one year old will receive the drug or a placebo before wa…

This study tests whether giving growth hormone to elderly patients (60+) with moderate to severe brain injury and low blood protein can improve their nutritional status. Half of the 160 participants will get daily growth hormone shots plus standard care, while the other half gets…

This study tests a robot-assisted, gamified rehabilitation program for children aged 7-16 with acquired brain injury. The program combines 15 supervised hospital sessions with 15 home-based sessions on a tablet, guided by an interactive avatar. Researchers will measure improvemen…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This study tests whether an interactive virtual reality (VR) system, where patients move to play games, can improve arm and leg function better than just watching VR. Sixty adults recovering from a stroke or traumatic brain injury will use the VR system three times a week for eig…

This study tests whether combining spinal cord stimulation with physical therapy can improve arm and hand movement in people with cervical spinal cord injury. Forty participants will receive either real stimulation or a sham version during 20 therapy sessions over 6-8 weeks. Rese…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study will test whether combining exoskeleton-assisted walking with a mild electrical stimulation to the spinal cord can improve muscle size and bone strength in people with chronic spinal cord injury. Twenty-four participants who have been injured for more than three years …

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study tests whether combining spinal cord stimulation with physical therapy can help people with non-traumatic spinal cord injury regain leg movement and the ability to stand or step. Ten adults who have had a spinal cord injury for at least one year and cannot walk independ…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests whether a home-based telerehabilitation program using a virtual reality device can help people recover motor and cognitive skills after a severe acquired brain injury as effectively as in-person therapy. Sixty-two adults aged 18 to 75 with brain injury will be as…

This early-stage trial tests whether a single dose of CRIS100 is safe for people with a recent spinal cord injury in the upper back. Only 5 adults with severe injuries will receive the drug directly at the injury site within 72 hours. The study focuses on side effects and lab cha…

This study tests whether a device that gently stimulates a nerve in the ear can reduce brain damage and inflammation after a traumatic brain injury or bleeding stroke. Sixty adults will be randomly assigned to receive either real stimulation or a sham (fake) treatment. Researcher…

This study tests whether a sodium lactate infusion is safe for people with severe traumatic brain injury in the ICU. Researchers will monitor side effects and survival in 264 adults. The goal is to see if this approach is safe enough to study further.

This study tests whether walking in a robotic exoskeleton combined with mild electrical stimulation of the spinal cord can improve muscle and bone health in people with chronic spinal cord injury. About 24 participants will be assigned to either active or sham stimulation during …

This study tests whether setting a personalized 'optimal' blood pressure for each patient with severe traumatic brain injury reduces brain damage compared to standard fixed targets. Researchers will enroll 60 adults in the ICU and measure brain injury markers in the blood over fi…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study tests whether tranexamic acid (TXA), a drug that helps stop bleeding, can improve recovery in 2000 severely injured children with brain or torso injuries. The goal is to see if TXA reduces bleeding and improves quality of life and thinking skills. The trial is for chil…

This study tests whether metformin, a common diabetes medicine, can help people recover after a spinal cord injury. The drug may reduce scar tissue that blocks nerve healing. Researchers will give metformin or a placebo to 34 adults with recent thoraco-lumbar spinal cord injury a…

This study tests whether a special arm-crank exercise (eccentric training) can improve upper body strength and daily function better than standard strength training for people recovering from a spinal cord injury. Twenty participants will do 20 sessions of one type of training ov…

This early-phase study tests whether a concentrated form of the patient's own growth factors can improve motor function after a spinal cord injury. Ten adults with moderate to severe traumatic spinal cord injury will receive the treatment. The goal is to see if this approach can …

This study tests a new stem cell therapy called XS228 for people with recent spinal cord injuries. The treatment uses lab-made nerve cells injected into the spinal fluid to help repair damage. About 60 adults with incomplete paralysis will receive either XS228 or a placebo and be…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This study tests whether a single dose of valproic acid, given soon after a moderate to severe traumatic brain injury, can improve patients' recovery and reduce disability. About 432 adults aged 18 to 65 will be randomly assigned to receive either valproic acid (at a low or high …

This study tests whether a 5-day course of the steroid methylprednisolone can improve long-term recovery in adults with moderate to severe traumatic brain injury. 520 participants will receive either the drug or a placebo, added to standard care. Researchers will measure neurolog…

This study will test a device called Delphi-MD that uses magnetic pulses and brain wave recordings to diagnose traumatic brain injury (TBI). Researchers will compare results from 215 people with TBI to healthy controls, looking for patterns that could help identify and assess bra…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study will test a blood test called the Abbott i-STAT™ TBI Plasma Test in 200 adults who come to the emergency room with a traumatic brain injury. The test looks for two brain proteins (GFAP and UCH-L1) in the blood. Researchers will compare the blood test results to CT scan…

This study tests a portable device that uses near-infrared light to find brain bleeds in people with traumatic brain injury. The goal is to see if it works as well as a CT scan, especially in places like battlefields or rural areas where CT machines aren't available. About 80 adu…

This study will check if a non-invasive device can accurately detect high pressure inside the skull in 300 adults with traumatic brain injury or stroke. The device uses a sensor placed on the head to measure brain pressure and pulse waves. If successful, it could help doctors mak…

This study looks at whether three bedside ultrasound techniques—TCCD, ONSD, and ODH—can accurately detect high pressure inside the skull (intracranial hypertension) in people with traumatic brain injury. Researchers will compare these non-invasive methods to the standard invasive…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months …

This study tests whether a simple pre-game safety huddle—where coaches, referees, and players briefly talk about the importance of reporting concussion symptoms—can improve concussion reporting in youth soccer. Researchers will enroll 2,000 children aged 9-13 and their coaches ac…

This study looks at whether a single dose of the antibiotic ceftriaxone can prevent early pneumonia in 60 brain-injured patients who need a breathing tube. Researchers will measure drug levels in the blood to see if enough reaches the infection site, especially in patients with f…

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether spending time in nature can help people recover faster from a concussion. 24 participants aged 14-35 who recently had a concussion will either do guided awareness exercises in a natural setting or indoors. Researchers will track symptoms, thinking speed, …

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study tests a 12-week program where a person with traumatic brain injury and a close supporter work with a therapist to improve communication and emotional support. The goal is to reduce isolation and improve health. The study involves 60 participants and focuses on whether …

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and problem-solving in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized …

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This study tests a 14-day home program called BraW-Day™ that combines brain exercises (like counting backwards) with walking, delivered via a smartphone app. Researchers want to see if doing both tasks together improves thinking, balance, and mood in athletes aged 18-40 who had a…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether playing virtual reality games like Beat Saber can improve memory, attention, and thinking speed in people with acquired brain injury. Fifteen participants will do 15 sessions of VR training over 5 weeks, plus their usual rehab. The goal is to see if this …

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests a stepped-care version of Parent-Child Interaction Therapy (PCIT) for children aged 2 to 7 who have a mild to moderate traumatic brain injury and behavior problems. The program teaches parents positive parenting skills through online modules and weekly therapist …

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study tests a 12-session group program called ENGAGE-TBI for adults who had a traumatic brain injury (TBI) at least 6 months ago. The program, led by an occupational therapist and a TBI survivor, focuses on social skills and problem-solving. Researchers want to see if it's p…

This study tests a patient empowerment program for veterans with spinal cord injury and neurogenic bladder who have had at least one urinary tract infection in the past year. The program provides training and tools to help them recognize when antibiotics are not needed and advoca…

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests whether a mindfulness app can help teenagers aged 12 to 17 recover from a mild concussion or traumatic brain injury. The goal is to see if using the app improves quality of life and resilience compared to standard care. The study will involve 362 participants fro…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study tests whether a gentle electrical current applied to the spinal cord (transcutaneous spinal cord stimulation) during assisted cycling can improve leg movement, reduce muscle spasms, and help bladder/bowel control in adults with incomplete spinal cord injury. Forty part…

This study tests a new AI system that adjusts electrical stimulation to the spine in real time while people with spinal cord injury walk. The goal is to improve muscle activation and walking ability compared to standard stimulation. The study involves 7 participants and focuses o…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests a home-based digital rehabilitation program combined with a non-invasive spinal cord stimulation device to improve upper limb function in people with chronic tetraplegia. Nine participants will use a mobile app-guided exercise program with daily stimulation over …

This study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…

This study tests a program called COMA-F, designed to help caregivers of patients with severe acute brain injury manage emotional distress. The program teaches skills to cope with uncertainty and long-term caregiving challenges. Researchers will compare it to a basic education pr…

This pilot study tests whether combining non-invasive brain stimulation (over the cerebellum) with spinal cord stimulation can improve arm and hand function in people with chronic cervical spinal cord injury. Twenty-four participants will receive either both stimulations, spinal …

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests whether virtual reality relaxation sessions can help adults with acquired brain injury who live in nursing homes and have emotional or behavioral issues. Three participants will use a multisensory VR device for 15–20 minutes twice a week over 8 weeks. Researchers…

This study tests whether an AI-powered mobile app can help people with spinal cord injury manage bowel dysfunction. About 34 adults will use the app for 12 weeks to see if it reduces bowel problem scores, shortens bathroom time, and improves quality of life. The goal is to make d…

This study tests whether a single 30-60 minute Crisis Response Planning (CRP) session can reduce suicide risk in 120 active-duty military personnel who have had a mild traumatic brain injury (mTBI). Participants will be randomly assigned to CRP or usual care, and researchers will…

This study tests a family-centred talking therapy (ACT) for young people aged 11-18 with acquired brain injury and their parents. Up to 6 families will receive 12 online therapy sessions. The goal is to see if the therapy is feasible and can improve emotional wellbeing, psycholog…

This study tests whether wearing a head-cooling device for 28 days can help women ages 18-27 recover from a concussion. Researchers will measure changes in thinking, sleep, mood, and brain inflammation. The goal is to see if cooling the brain speeds up recovery and eases symptoms…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…

This study tests whether combining loud sounds and mild electrical stimulation with walking practice can improve walking speed and leg strength in people with chronic spinal cord injury. About 20 adults with incomplete spinal injuries who can stand and have some ankle movement wi…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This early study tests whether delivering small electrical pulses over the skin above the spinal cord, alongside standard therapy, can help people with a recent spinal cord injury regain arm and hand function. Twenty participants will receive either active or sham stimulation dur…

This study tests a leg-worn device called AccelBand that uses mild electrical pulses to improve bowel function in people with spinal cord injury. One hundred participants will either receive active treatment or a sham (inactive) version for four weeks. Researchers will measure ch…

This study tests whether a short form of therapy called Focused Acceptance and Commitment Therapy (FACT) can help people with spinal cord injuries improve their mental health and quality of life while still in the hospital. Eight participants will complete questionnaires before a…

This study tests a robotic exoskeleton called CLINICAL EXPLORER in 60 children aged 2 to 17 with neurodevelopmental disorders like cerebral palsy. The device supports walking during 8 therapy sessions. Researchers will check if it is safe, easy to use, and helps improve movement …

This study will test whether a mild electrical stimulation applied to the lower back, combined with walking exercises, can improve mobility and balance in people with traumatic brain injury (TBI) who have weakness on one side. Thirty adults with a non-penetrating TBI at least two…

This study investigates why severe traumatic brain injury (sTBI) often leads to additional brain damage. Researchers think changes in the gut and immune system may play a key role. They will analyze blood, stool, and other samples from 40 adults with sTBI, as well as from trauma …

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study aims to see if special MRI scans can help predict how well people recover from moderate to severe traumatic brain injury (TBI). Researchers will scan 100 adults aged 18 to 60 soon after their injury and then check their recovery one year later. The goal is to find brai…

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard neck and balance rehab helps people with persistent symptoms after a mild concussion. It will include 34 adults aged 18–70 who still have dizziness, neck pain, or headaches at least two weeks after …

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study checks on children who had a moderate to severe head injury years ago to see if they have any lasting hormone or growth problems. Researchers will call participants for a 15-minute interview to measure their height and ask about symptoms. The goal is to learn how commo…

This study tests a new method that uses carbon dioxide measurements to help doctors set breathing machines more precisely for brain injury patients. The goal is to reduce lung damage while keeping the patient stable. The study will include 30 adults in a neuro-intensive care unit…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study looks at how inflammation in the nervous system affects pain and recovery after elbow fractures or dislocations. Researchers will take blood samples from 60 adults before and after surgery to measure specific inflammatory markers. The goal is to better understand why s…

This study aims to improve balance problems after a mild traumatic brain injury (concussion). Researchers will develop a new exercise program that focuses on how the body responds to imbalance, and compare it to standard balance therapy. The study will involve 80 adults aged 18-6…

This observational study will look at how fear of movement (kinesiophobia) relates to independence, fear of falling, pain, and mood in 70 adults with paraplegic spinal cord injury. Participants will fill out questionnaires during one visit. The goal is to better understand these …

This study will test whether playing selected music through headphones can help people in a coma after a severe traumatic brain injury recover cognitive function. Researchers will compare 35 patients who receive music therapy to similar patients from the past who did not. They wi…

This study tests a robotic system that monitors vital signs in patients with severe brain injury. The robot works alongside standard care to detect early signs of decline. Researchers will measure how usable and acceptable the robot is for staff and patients. The goal is to see i…

This study looks at how quickly people with paraplegic spinal cord injury can mentally picture moving their hands or feet compared to healthy individuals. Researchers will use a computer task where participants identify left or right hand/foot images. The goal is to understand ho…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This early-stage study tests whether a device that gently stimulates a nerve in the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults will receive either real or sham stimulation while in the hospital. The main goal is to see if t…

This study will look back at medical records of 800 children aged 0-18 who came to the emergency room with a mild traumatic brain injury and had a head CT scan. Researchers want to see if routine blood tests (like white blood cell count, CRP, and glucose) can predict whether the …

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at whether certain proteins in the blood can signal brain injury in children who have heart surgery with a heart-lung machine. Researchers will measure these proteins before and after surgery and compare them to the child's brain function. The goal is to find a s…

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study looks at whether an EEG (a brain wave test) can better tell the difference between people who are unresponsive but awake and those who show minimal signs of awareness after a severe brain injury. About 42 adults will take part. The goal is to see if brain responses to …

This study will test a new way to assess concussion in football players by having them perform cognitive and motor tasks right on the field, like counting whistles while dribbling. Researchers aim to standardize these 'ecological' tests so they can be used as a baseline before th…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study will look back at the medical records of 50 people with spinal cord injuries treated over the last five years. Researchers want to understand common causes of injury, levels of paralysis, and what complications patients faced, such as pressure sores or infections. The …

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This exploratory study will use an upright MRI scanner to take 3D images of the bladder in 20 people—some with spinal cord injury who use catheters, and some healthy volunteers. The goal is to understand how the bladder and surrounding structures change shape during catheter use …

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study looks at whether a steroid called dexamethasone can improve recovery in people with traumatic brain injury who develop brain swelling. Researchers will follow 280 adults aged 18 to 70 who already receive this treatment as part of their care, comparing their outcomes to…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study tests whether mild hypothermia (cooling the body to about 33°C) during coronary artery bypass grafting protects the brain better than normal temperature (about 36.5°C). Researchers will use advanced brain scans and blood tests to measure brain injury in 160 adults unde…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study tests whether gentle, non-invasive brain stimulation can help people with traumatic brain injury (TBI) remember locations better. Participants will use a virtual reality game to find objects while their brain is stimulated or not. The goal is to see if stimulation impr…

This study looks at 40 veterans with chronic spinal cord injury to find any remaining nerve connections below their injury. Researchers will use MRI scans and non-invasive stimulation to measure these connections. The goal is to understand who might benefit from future treatments…

This study looks at 150 people who have had a brain injury from a stroke, bleed, or trauma. Researchers will track their sleep quality and mental health symptoms for up to a year using wrist monitors, brain activity sensors, and questionnaires. The goal is to understand if poor s…

This study will enroll 50 people with severe brain injuries to see if combining different types of monitoring—like blood sugar levels, brain waves, and blood flow—can help predict how well they will recover. Researchers will follow participants for 6 months to check their neurolo…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study tests whether a hand rehabilitation device called ReHandyBot, paired with a smartphone app called RehabCoach, can help people recover after a stroke, traumatic brain injury, or orthopedic problem. Thirty participants will first use the device under supervision at a cli…

This study will follow 50 people with brain hemorrhage to see if a feature called the 'spot sign' on CT scans can predict who is at higher risk of death or disability. Researchers will compare these scan findings with standard risk scores. The goal is to improve early identificat…