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Bedside ultrasound could flag hidden brain injury decline

NCT ID NCT07820527

Diagnosis Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
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Paused for now. It may or may not start again.
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Cancelled before anyone took part.

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Approved
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When the status isn't known

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Status unknown
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First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are studying whether two bedside ultrasound techniques can help emergency doctors identify traumatic brain injury patients at risk of getting worse within 24 hours. The study enrolls 60 adults with acute traumatic brain injury and a low Glasgow Coma Scale score who are initially treated without surgery. Doctors measure blood flow in the brain's middle cerebral artery and the width of the optic nerve sheath at emergency department arrival, with repeat measurements at 24 hours when possible. The goal is to see whether these measurements, added to clinical exams and CT scans, can predict early neurological deterioration.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial Doppler ultrasound and optic nerve sheath diameter measurement
What this could lead to
If it works, this could give emergency doctors a fast, bedside ultrasound check to spot brain injury patients who need closer watching before they worsen.
What could go wrong
This is a small observational study at one hospital, so the ultrasound measurements may not reliably predict decline or may not apply to other emergency departments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients presenting to the Emergency Department with acute traumatic brain injury, a baseline GCS score ≤13, and an initial CT brain scan demonstrating a traumatic intracranial structural lesion, who meet the predefined eligibility criteria and are initially managed conservatively/non-operatively.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 18 years or older. 2. Acute traumatic brain injury diagnosed clinically and/or radiologically. 3. Initial Glasgow Coma Scale (GCS) score ≤13. 4. Initial CT brain scan demonstrating a traumatic intracranial structural lesion. 5. No indication for immediate neurosurgical intervention at initial assessment. 6. Initially managed conservatively/non-operatively according to the treating team. 7. Informed consent obtained from the patient or legally authorized representative. Exclusion Criteria: 1. Immediate neurosurgical indication requiring urgent intervention. 2. Immediate life-saving procedure or clinical instability preventing safe completion of the research ultrasound assessment. 3. Significant orbital trauma or ocular pathology interfering with reliable optic nerve sheath diameter measurement. 4. Previous decompressive craniectomy. 5. Inadequate temporal acoustic window preventing reliable middle cerebral artery transcranial Doppler assessment. 6. Refusal to participate or withdrawal of consent.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic intracranial hypertension traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic brain injury

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Assiut University Hospitals

    Asyut, Asyut Governorate, 85811, Egypt

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