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Can a web program rebuild memory after brain injury?

NCT ID NCT05413733

Symptom relief Sponsor: Helsinki University Central Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and questionnaires to help people manage attention, memory, and fatigue. The trial compares this digital approach with standard care to see if it is feasible and effective. Participants must be within six months of their injury, have mild to moderate cognitive difficulties, and be able to use digital devices.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a web-based neuropsychological rehabilitation program called the iRENE Digital Pathway
What this could lead to
If it works, this could offer a home-based option for cognitive rehabilitation after brain injury, potentially improving access for people who cannot attend frequent in-person visits.
What could go wrong
This is a small feasibility study of 21 people, so it may not show clear benefits or may not generalise to larger or more diverse groups. Digital programs can also be hard to stick with, and some people may not have the skills or equipment to use them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Aug 2022

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute neurological incident affecting cognition (stroke, encephalitis, traumatic brain injury, anoxia) * Less than 6 months from occurrence of an acute neurological incident * Mild to moderate cognitive deficits on a clinical neuropsychological assessment during inpatient or outpatient care after ABI * Subjective cognitive symptoms following ABI * Proficient in Finnish * Must be able to use digital appliances Exclusion Criteria: * Not an acute neurological incident * More than 6 months from an acute neurological incident * Severe cognitive deficits on a clinical neuropsychological assessment during inpatient or outpatient care after ABI * Not fluent in Finnish * Not able to use digital appliances

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia Brain Injuries, Traumatic brain injury encephalitis hemorrhagic stroke intracerebral hemorrhage Intracranial Hemorrhages ischemic stroke traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain hemorrhage Encephalitis Hypoxia-ischemia, brain Stroke, acute ischemic Traumatic brain injury

Contacts and locations

Locations

  • HUS Neurocenter, Helsinki University Hospital

    Helsinki, FI-00029, Finland

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