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Zapping the brain to restore lost vision

NCT ID NCT07105358

Symptom relief Sponsor: Georgetown University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults with hemianopia, a visual field defect caused by stroke, brain tumor, or traumatic brain injury. Participants complete a computer task that asks them to judge the direction of moving dots while receiving either real tRNS or a sham stimulation, and researchers measure changes in their motion detection and visual field. The goal is to see if combining brain stimulation with practice can help the brain rewire itself to improve vision.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial random noise stimulation (tRNS), a mild electrical brain stimulation, combined with perceptual learning-based visual training
What this could lead to
If it works, this could offer a non-invasive way to help people regain some vision lost to brain damage, possibly adding to standard visual rehabilitation.
What could go wrong
This is a small, early-stage study of 30 people, so any benefits may be modest or may not hold up in larger trials. The stimulation can cause mild scalp tingling or discomfort, and results may differ depending on the type and location of brain injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

A. Stroke, brain tumor, or traumatic brain injury patients Inclusion Criteria: 1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. 3. Unilateral or bilateral focal brain damage causing loss of vision. 4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year. Exclusion Criteria: 1. Severe CNS diseases or disorders unrelated to the focal lesion, which could interfere with study results. 2. Severe mental health challenges that could interfere with study results, or current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5. 3. Vision loss resulting from ocular disease or disorder. B. Healthy volunteers (age-matched controls): Inclusion Criteria: 1. At least 18 years of age. 2. Capable of providing informed consent and complying with study procedures. Exclusion Criteria: 1. Any CNS diseases or psychiatric disorders (e.g., epilepsy, schizophrenia) that would interfere with study results. 2. Previous head injury. 3. Present or past (within past 6 months) drug or alcohol abuse or addiction based on DSM-5.

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Conditions

The condition(s) this trial relates to.

brain cancer Brain Injuries, Traumatic brain neoplasm cortical blindness Hemianopsia stroke disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain tumor Cortical blindness Hemianopia Quadrantanopia Stroke Traumatic brain injury Visual field defect Visual field defect, peripheral

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Georgetown University Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20057, United States

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