Could a single dose of valproic acid help heal the brain after injury?
NCT ID NCT07166393
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether a single dose of valproic acid, given soon after a moderate to severe traumatic brain injury, can improve patients' recovery and reduce disability. About 432 adults aged 18 to 65 will be randomly assigned to receive either valproic acid (at a low or high dose) or a placebo, alongside standard care. The main goal is to see if the drug leads to better outcomes on a scale that measures recovery from death to full independence.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
valproic acid
What this could lead to
If it works, this could point toward a simple, one-dose treatment to improve recovery and reduce disability after a traumatic brain injury.
What could go wrong
This is an early-to-mid stage trial, so the drug may not prove effective. Valproic acid also has known side effects, including liver problems and bleeding risk, which could limit its use.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of Arizona
Tucson, Arizona, 85719-4824, United States
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University of California, Davis
Sacramento, California, 95817, United States
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University of Southern California
Los Angeles, California, 90089-0701, United States
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University of Texas Southwestern
Dallas, Texas, 75390, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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