Nervous system injury

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This study tested a new way to monitor blood flow to the brain during heart surgery to prevent brain injury. It included 460 high-risk patients having heart surgery with a heart-lung machine. The goal was to see if this monitoring could reduce strokes, new brain lesions, or memor…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This study tested whether dexmedetomidine, a sedative drug, can protect the brain in people with brain injuries. Sixty patients were split into two groups: one received the drug, the other did not. Researchers measured consciousness levels and how long patients stayed in the ICU,…

This pilot study tested a sleeve worn on the forearm that uses muscle signals to stimulate hand muscles, helping people with tetraplegia from spinal cord injury grasp and manipulate objects. Twelve adults with chronic cervical SCI completed a 12-week training program using the de…

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The procedure involves steps like deflating the tube cuff and using a speaking valve, with a team of doctors and nurses monitoring stability. The goal …

This study tested a Norwegian intensive habilitation program for children aged 2-6 with severe cerebral palsy or similar brain damage. The program aimed to improve the child's daily living skills and empower parents. 93 children and their families took part in a randomized trial …

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…

This study tested a device called ExaStim that uses mild electrical stimulation on the skin over the spinal cord to help people with chronic cervical spinal cord injury improve arm and hand function. Thirty-three participants used the device at home for 4 weeks after a training p…

This study tested a special balance training program for people with incomplete spinal cord injury who are at high risk of falling. The training involved unexpected pushes or pulls to trigger a stepping response, with some participants also receiving electrical stimulation to hel…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study tested a new rehabilitation approach for people with spinal cord injury. Ten participants received a spinal cord stimulation implant and used a robotic exoskeleton to help them walk. The goal was to improve leg muscle strength and overall quality of life. The combinati…

This study tested a new therapy that combines two types of electrical stimulation with balance training (like video games) to help people with incomplete spinal cord injury improve their standing balance. Seventeen participants completed 12 sessions over 4 weeks. The goal was to …

This study tested a closed-loop ventilation system (INTELLiVENT-ASV) in 20 adults with acute brain injury who needed a breathing machine. The goal was to see if this smart system could provide safer, more effective breathing support compared to standard ventilation. Researchers m…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…

This study tested whether combining a mild brain stimulation technique (tDCS) with a new mental and physical rehab method (NEUROM) can help people with chronic spinal cord injury regain leg movement and feeling. Fifty-six participants with paralysis below the lower back were rand…

This study tested an experimental drug called elezanumab in people with a recent cervical spinal cord injury. The goal was to see if the drug could improve arm and hand movement and was safe. About 60 adults aged 18-75 with severe neck-level injuries received either the drug or a…

This study looked at whether a ketogenic or modified Atkins diet can help people recover from moderate to severe traumatic brain injury. The diet aims to change how the brain uses energy, potentially improving function. Twenty-one participants were enrolled, and researchers measu…

This pilot study tested whether combining neuromuscular electrical stimulation with daily vitamin D could improve bone health in veterans with chronic spinal cord injury. Six participants underwent 9 months of treatment, with bone changes measured by MRI and DXA scans. The goal w…

This study tested whether stem cells taken from a patient's own fat and given by IV are safe and might help the brain heal after a traumatic brain injury. 24 adults with long-term brain damage received the treatment. Researchers checked vital signs and measured inflammation marke…

This study tested whether cooling the brain based on its own temperature, rather than body temperature, improves fever control in severe brain injury patients. 41 adults with brain injury and fever were enrolled. The intervention group used an external cooling device guided by br…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested a drug called MT-3921 (Unasnemab) in 72 people with recent severe neck spinal cord injuries. The goal was to see if it could improve arm and hand function better than a placebo. Participants received the drug or placebo by IV over 6 months, and their motor score…

This study tested whether adding functional electrical stimulation (FES) bicycle ergometry to robotic rehabilitation helps people with chronic incomplete spinal cord injury walk better. 38 participants completed 20 sessions over 4 weeks. The goal was to see if the combination imp…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This study tested whether adding two drugs—cerebrolysin and amantadine sulfate—to standard care helps people with moderate to severe traumatic brain injury recover in the ICU. 150 adults aged 18-70 took part. Researchers measured consciousness, disability, and recovery over 6 wee…

This early-stage trial tested a single dose of an experimental drug called ALMB-0166 in 24 people with acute spinal cord injury. The main goal was to check safety and how the drug moves through the body. Participants had moderate to severe injuries and were scheduled for surgery …

This small pilot study tested whether pairing vagus nerve stimulation with rehabilitation is safe and feasible for people with cervical spinal cord injury. Six participants received an implanted nerve stimulator and underwent rehab sessions. The study focused on safety and whethe…

This study tests whether a 12-week adaptive exercise program can reduce chronic inflammation in people with spinal cord injury (SCI). Chronic inflammation is linked to heart and lung disease, the top causes of death in SCI. Twenty-four adults with SCI will be randomly assigned to…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This phase 2 trial tested whether combining testosterone therapy with a special type of electrical stimulation (long pulse width) could rebuild leg muscle in 12 people with spinal cord injury whose muscles no longer respond to standard electrical stimulation. Participants receive…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This early-phase trial tested a device called SC0806, which is surgically implanted into the spine. It releases a growth factor to encourage nerve repair in people with complete spinal cord injury. Ten participants were randomly assigned to receive either the device plus rehabili…

This study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This study tested whether a brain-computer interface (BCI) training program could improve hand and arm function in people with recent spinal cord injuries. Thirty participants used a system that reads brain signals during hand motor imagery exercises. The goal was to see if this …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can help doctors safely avoid CT scans in children with mild traumatic brain injury. Over 1,500 children across Europe participated. The goal was to see if these blood tests are accurate enough to …

This study tested whether a bedside ultrasound (POCUS) can accurately detect skull fractures in children aged 2-18 with mild closed head injuries. Researchers enrolled 95 children in the emergency department and compared ultrasound results to CT scans. If effective, this approach…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study tested a blood test called VIDAS TBI on 903 adults with mild head injuries in the emergency room. The test measures two brain proteins to see if it can reliably rule out brain damage. If it works well, it could help doctors decide who truly needs a CT scan, saving time…

This study tested a handheld device that uses near-infrared light to quickly detect bleeding inside the skull after a head injury. Researchers compared the device's results to CT scans in 180 patients in Uganda. The goal was to see if this portable tool could help diagnose brain …

This study tested whether a special goggle system (Neurolign Dx_100 I-PAS) and standard tests can reliably detect mild traumatic brain injury (concussion) in people who recently had a head injury. Researchers compared 161 people with concussions to those with minor injuries. The …

This study tested whether measuring S100B protein levels in the blood can safely rule out serious brain injuries in adults with minor head trauma who take antiplatelet drugs (blood thinners). 720 participants had a blood test upon arriving at the emergency room, followed by a CT …

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can safely tell doctors when an older adult with a mild head injury does not need a CT scan. Over 2,200 participants aged 65 and older were enrolled. The goal is to reduce unnecessary radiation and…

This study tested a simple, portable virtual reality balance test (called VETS) to see if it could help diagnose and track cervical spondylotic myelopathy (CSM), a spinal cord condition common in veterans. Eight participants with CSM and a control group performed balance tasks un…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This study tested a portable device called the Infrascanner that uses light to check for expanding brain bleeds in people with traumatic brain injury. About 400 participants who had a head injury and a brain bleed seen on a CT scan were monitored hourly with the scanner. The goal…

This study tested whether a portable goggle system with eye-tracking technology can accurately diagnose mild traumatic brain injury (mTBI) in community settings like emergency rooms. Researchers enrolled 120 adults aged 18-50 who had a head injury with symptoms. The goal was to s…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This pilot study tested a non-invasive device that stimulates the vagus nerve (nVNS) in patients hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if adding nVNS to standard care could prevent severe lung inflammation and the need for a breathing mach…

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tested whether using a brain oxygen monitor (cerebral NIRS) along with a treatment guideline could prevent brain injury in very low birth weight preterm infants. 129 babies born at 32 weeks or earlier or weighing under 1500 grams took part. The monitor was placed on th…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tested whether a guided, telehealth-based aerobic walking program could improve thinking, mood, and quality of life in people who had a traumatic brain injury (TBI). Researchers enrolled 112 participants and measured changes in brain blood flow, walking ability, and me…

This study tested whether a device that gently stimulates a nerve in the ear, used at home for one hour a day over two weeks, could help improve thinking and memory in people with mild to moderate traumatic brain injury. Seven adults took part to see if the treatment was practica…

This study tested whether hypnotic suggestion can improve working memory in adults who had a brain injury at least a year earlier. 90 participants received either four weekly sessions of hypnosis or mindfulness. The goal was to see if hypnosis could unlock hidden memory capacity …

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested three different treatment approaches for teens aged 13-19 who had a concussion within the past three weeks and were still experiencing moderate to severe symptoms like headaches, dizziness, and neck pain. The goal was to see if early, symptom-specific treatments…

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This study tested whether guided emotional and sensory stimulation from family members could help coma patients with traumatic brain injury recover. 120 patients were split into two groups: one received standard care, the other added structured family interaction like talking, ge…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This small pilot study looked at whether a single yoga-based physical therapy session could improve heart rate variability (a measure of stress resilience) in people with traumatic brain injury. Thirteen adults participated in three different activities on separate days: yoga the…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This small study tested whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injuries. Sixteen participants received the stimulation over two visits. The main goal was to check for side e…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This study tested a new memory training program for people who have memory problems after a brain injury (like a stroke or head injury). Six participants either received standard treatment or a shorter program that included a special memory game to practice at home. The goal was …

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This study tested a 'Digital Strolling' program where people with severe mobility impairment use a virtual reality headset to walk in a digital world. 24 participants either used the VR walking or watched walking videos for 10 days. The goal was to see if this approach could impr…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether adding a special nerve stimulation treatment to standard exercise could improve neck disability in people with whiplash from a car accident. 44 adults with recent whiplash were split into two groups: one did only exercises, the other did exercises plus t…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this combination improves aerobic fitness, daily function, and overall health better than…

This study tested whether giving N-Acetylcysteine (a supplement) along with multivitamins and minerals can help older adults (60+) recover from a traumatic brain injury. The goal was to see if it reduces thinking, emotional, and physical symptoms like headaches or memory problems…

This study tested a low-cost elastic band device designed to help therapists assist people with spinal cord injury while walking on a treadmill. The device uses rubber bands to help move the legs forward during walking. Nineteen participants with spinal cord injury tried the devi…

This study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…

This completed study tested a 7-week, peer-led program for adults with spinal cord injury and chronic pain. The program combined education about pain neuroscience with body-based tools like red light therapy, massage, and guided movement. Twelve participants attended group sessio…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study tested whether people with spinal cord injuries can reach a high-intensity heart rate while walking in a robotic exoskeleton. Eleven participants completed five training sessions using the Ekso device. Researchers measured heart rate, walking speed, and endurance befor…

This study tested whether a mild electrical stimulation (40 kHz) applied through the skin can safely reduce nerve pain in people with spinal cord injury. Thirty adults with paraplegia and chronic nerve pain received either real or placebo stimulation alongside their usual treatme…

This study tested whether wearing earplugs and an eye mask during an MRI scan can lower anxiety. 72 adults having their first MRI were split into two groups: one used the earplugs and eye mask, the other did not. Researchers measured changes in blood pressure, heart rate, breathi…

This study tested a new device called Intensive Neurowave Emotional Stimulation (INES) in 40 people with disorders of consciousness after severe brain injury. The experimental group received multisensory stimulation with emotionally meaningful audio-visual content, while the cont…

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested whether taking creatine monohydrate daily for seven weeks could reduce persistent symptoms after a mild concussion. 34 adults aged 20-45 who had symptoms for 6-18 months took part. The results showed no clear benefit compared to placebo or usual care, but the st…

This study tested a special nursing approach, called the Tidal Model, to help caregivers of people with traumatic brain injury. 18 caregivers took part and the program aimed to reduce their anxiety, depression, and burnout. The approach focused on understanding each caregiver's p…

This study tested two types of magnetic brain stimulation (TMS) to see if they can reduce nerve pain in people with spinal cord injury. 26 adults with long-term nerve pain that didn't respond to medication took part. The goal was to measure changes in pain severity, daily functio…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…

This completed Phase 3 trial tested whether brivaracetam, a drug used for seizures, can reduce chronic nerve pain in people with spinal cord injury. 44 adults with persistent pain took part. The study compared brivaracetam to a placebo and measured changes in pain intensity and d…

This study tested a device that combines mild electrical muscle stimulation with a balance-board video game to help people with spinal cord injury or stroke improve their balance and reduce fall risk. 18 adults who were at least one year past their injury took part. The goal was …

This study tested two types of magnetic brain stimulation (iTBS and rTMS) combined with robotic walking therapy in 30 people with chronic spinal cord injury. The goal was to see if these treatments could improve leg strength, walking ability, and daily independence. All participa…

This study tested whether buspirone (Buspar), a drug used for anxiety, can reduce irritability and aggression in people who have had a traumatic brain injury. 81 adults with a closed head injury at least 6 months prior took either buspirone or a placebo for 91 days. The goal was …

This study tested a gentle electric current (tDCS) on the brain to see if it could help people with a past traumatic brain injury find words more easily. Fourteen adults with long-term word-finding problems took part. They received either real or fake stimulation while doing memo…

This study tested two 8-week home exercise programs for 96 adults with spinal cord injury. One program used movement to music, the other standard exercises. Researchers measured physical activity levels and pain to see which approach worked better.

This study tested a lightweight robotic suit called the Myosuit in 34 people with incomplete spinal cord injury. Participants used the suit during walking exercises and then took it home for six weeks to see if it improved their daily walking. The goal was to measure changes in w…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This small study tested whether functional electrical stimulation (FES) arm cycling could improve arm strength and function in people with recent spinal cord injury. Six participants with cervical-level injuries cycled with electrical stimulation 3 times a week for 6 weeks. The s…

This small study tested whether a gentle electric current applied to the scalp (tDCS) could improve word-finding in 5 civilians who had a traumatic brain injury more than a year ago. Participants received both real and sham stimulation to see if the real treatment boosted verbal …

This study tested a robotic leg brace called the ABLE Exoskeleton in 14 people with acquired brain injury (including stroke). Participants used the device during 10 walking training sessions over up to 6 weeks. The main goals were to see if the device is safe and easy to use, and…

This study looked at whether a type of talk therapy called prolonged exposure therapy can help reduce PTSD symptoms in people with spinal cord injuries. Thirty adults with both conditions were randomly assigned to receive the therapy or continue their usual care. The main goal wa…

This study tested a new online program to help people with spinal cord injury cope better and improve their mental health. Twelve adults with spinal cord injury and mild anxiety or depression took part in eight weekly online group sessions led by a nurse. The main goal was to see…

This study tested a personalized magnetic brain stimulation therapy called MeRT for people with PTSD. 158 adults received either real or sham treatment. The goal was to see if MeRT could safely reduce PTSD symptoms. The approach tailors the stimulation to each person's brain wave…

This study looked at whether high-intensity walking training is better than lower-intensity walking exercise for people with chronic, motor incomplete spinal cord injury. Researchers measured walking speed and distance in 53 participants. The goal was to find a more effective way…

This study tested whether giving lidocaine as a mist before suctioning the breathing tube can prevent dangerous spikes in brain pressure in children with severe traumatic brain injury. Ten children in the pediatric ICU received either nebulized lidocaine, lidocaine dripped into t…

This study tested a new approach to help people with spinal cord injury walk better. Participants received brief sessions of mild low-oxygen air (acute intermittent hypoxia) combined with gentle electrical stimulation on the back, plus walking practice. The goal was to see if thi…

This study tested whether a device that delivers a very mild electrical current to the scalp could improve memory in 26 older adults with mild cognitive impairment and a past traumatic brain injury. Participants received ten sessions of either real or fake stimulation to a brain …

This study tested a mobile app called Back2Play that guides youth through step-by-step return to school and physical activity after a concussion. Researchers wanted to see if using the app reduces symptoms, speeds up recovery, and lowers the chance of getting another concussion. …

This study tested an intensive motor rehabilitation program that uses advanced technology to help adults with chronic stroke or spinal cord injury improve their daily functioning. 102 participants were randomly assigned to either the tech-enhanced rehab or a control group. The go…

This study tested a computer game-based exercise program to help people with stroke or spinal cord injury improve hand and arm function. Thirty-five adults who were at least six months post-injury used a special mouse-like device to play games designed to practice hand movements.…

This small study tested a technique called acute intermittent hypoxia (AIH) — breathing low-oxygen air for short periods — to see if it could improve swallowing safety in people with chronic mild-to-moderate traumatic brain injury (TBI). Five adults completed the study, which com…

This study tested whether taking branched-chain amino acids (BCAAs) can improve sleep and thinking in veterans who have had a mild traumatic brain injury. 160 veterans were randomly assigned to receive different doses of BCAAs or a placebo for 12 weeks. The main goal was to see i…

This study looked at whether different types of physical exercise can help adults recover from a mild traumatic brain injury (concussion). 37 adults who had a concussion within the past year took part in a 3-month program of either balance or aerobic exercises. Researchers measur…

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study tested a nerve block (stellate ganglion block) combined with either dexmedetomidine or low-dose ketamine to treat 'neurostorm' — a dangerous overreaction of the body's stress system after a traumatic brain injury. The goal was to calm symptoms like high blood pressure,…

This study tested a distance-learning program for family caregivers of people with Alzheimer's dementia or traumatic brain injury. The goal was to reduce care-resistant behaviors like agitation and aggression, and improve quality of life for both patients and families. 88 caregiv…

This study tested whether an online program combining cognitive exercises and mindfulness training could help soldiers and veterans with mild traumatic brain injury (TBI) improve their memory, attention, and thinking speed. Twenty-three participants used either a specialized brai…

This study tested whether using a touch screen device (BITS) can improve visual field awareness in people recovering from a stroke or brain injury. 37 adults in inpatient rehab were assigned to either standard pen-and-paper vision exercises or exercises on the BITS touch screen. …

This study tested whether virtual reality (VR) exercises can improve memory and thinking in adults aged 65 and older who had a mild traumatic brain injury. Thirty participants used VR at home for six weeks. The goal was to see if VR could help with attention, memory, and visual s…

This study tested whether cannabidiol (CBD) can improve thinking, mood, and other symptoms in people who have had a traumatic brain injury (TBI). 43 adults with mild or moderate TBI took either CBD or a placebo for 12 weeks. Researchers measured changes in cognition, neuropsychia…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This study tested whether adding ear acupuncture (auricular thumbtack needle therapy) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with a Glasgow Coma Scale score of 4-8 were randomly assigned to receive…

This pilot study tested whether combining a mild brain stimulation technique (tDCS) with intensive language therapy can help people with non-fluent aphasia after a stroke. Ten participants received both real and sham stimulation during therapy sessions. The goal was to see if the…

This study tested a new approach to help people with cervical spinal cord injury improve arm and hand function. Participants received non-invasive brain stimulation combined with upper limb training over several weeks. The goal was to see if this combination could strengthen musc…

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This completed Phase 1 trial tested whether three FDA-approved drugs (cyproheptadine, carbidopa-levodopa, and atomoxetine) could improve hand function when combined with hand training exercises in 25 people with chronic spinal cord injury. Participants took a single dose of one d…

This study tested a special talking therapy (values-based cognitive behavioral therapy) for 6 adults with spinal cord injury from road accidents. The goal was to see if it helps reduce daily pain and improve living according to personal values. Participants attended 10 therapy se…

This early-phase study tested whether short bursts of low-oxygen breathing (acute intermittent hypoxia) combined with high-intensity arm training could improve hand and arm function in 58 people with chronic spinal cord injury. Participants had injuries between neck levels C1 and…

This completed study tested two different anesthetic drugs—dexmedetomidine and sufentanil—in 28 people having surgery for traumatic brain injury. The goal was to see which one keeps the brain's oxygen levels more stable during and after the operation. Researchers measured oxygen …

This study tested whether starting gentle leg cycling in bed within 48 hours after spinal surgery is safe and doable for people with severe spinal cord injuries. Forty-five adults took part, cycling for 30 minutes daily for two weeks. Researchers checked for safety, how many sess…

This study tested a 12-session telemedicine support group for people with brain injuries and their caregivers. The group taught coping skills and emotional support to improve confidence and well-being. Only 13 people took part, so the results are preliminary but suggest remote su…

This study tested whether daily electrical stimulation of the buttock muscles can help people with chronic spinal cord injury. Thirty participants used a device for 35 minutes each day over six months. Researchers measured muscle volume and sitting pressure to see if the stimulat…

This study tested whether therapy sessions delivered via iPad FaceTime could help people with spinal cord injury who feel depressed. 75 adults with recent spinal cord injury and mild to moderate depression received cognitive behavior therapy from a psychologist. The goal was to r…

This study tested a free service called Resource Facilitation for people with traumatic brain injury (TBI). Participants worked one-on-one with a specialist to set goals and connect with services. The goal was to see if this support improves quality of life and reduces disability…

This study tested a 12-week telemedicine coping skills group for brain injury survivors and their caregivers. Participants learned strategies to manage stress, depression, and communication challenges. The goal was to see if a virtual format could be as effective as in-person ses…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This small study tested whether combining virtual walking (watching a first-person walk video) with mild brain stimulation (tDCS) could help ease chronic nerve pain in people with spinal cord injury. Four participants tried the 2-week program, keeping pain diaries and reporting h…

This completed pilot study tested whether a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve attention and working memory in 56 active-duty service members who had a mild traumatic brain injury at least 6 months earlier.…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tested a new, non-invasive treatment for people with cervical spinal cord injury who have difficulty using their hands and arms. Fifteen participants received either electrical stimulation of the spinal cord combined with physical therapy, or physical therapy alone. Th…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested an experimental drug called AVP-786 in 168 people with traumatic brain injury who had symptoms like aggression, agitation, and irritability. The goal was to see if the drug could safely reduce these difficult behaviors. Participants received either the drug or a…

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study looked at whether doing light, symptom-free exercise helps teens recover faster from a sports-related concussion. 113 adolescents were randomly assigned to either a sub-threshold exercise group or a stretching placebo group. Both groups received standard medical care a…

This pilot study tested whether brivaracetam, a drug used for seizures, can reduce severe nerve pain in people with chronic spinal cord injury. 24 participants received either brivaracetam or a placebo for 3 months. The study aimed to see if a larger trial is possible and measure…

This study tested a personalized treatment plan for people with mild traumatic brain injury (concussion) that targets specific symptoms like anxiety, headaches, vision problems, and sleep issues. 169 adults with recent concussions were assigned to either the targeted treatment or…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The workshop taught coping strategies to reduce distress and improve reintegration into civilian life. 176 veterans…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…

This study looked at whether the drug tolcapone can help veterans with mild traumatic brain injury improve memory and self-regulation. Fifty-five veterans underwent brain scans and cognitive tests while taking either tolcapone or a placebo. The goal was to see if the drug changes…

This study tested whether personalized rehabilitation treatments help adults with persistent concussion symptoms better than usual care. 40 participants received either individualized therapy (aerobic exercise, mindfulness, or physical therapy) or standard care for 6 weeks, then …

This study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This study tested whether sitting in front of a bright lightbox for an hour each morning could improve sleep, reduce pain, and boost quality of life in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants used either a lightbox or a negative ion generator (pl…

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This phase 2 trial tested whether buspirone, a drug usually used for anxiety, can improve breathing capacity in people with chronic high-level spinal cord injuries. Thirteen participants took either buspirone or a placebo for 14 days. Researchers measured lung function, breathing…

This study looked at whether teaching military members to train service dogs can improve symptoms of PTSD, anxiety, depression, and concussion. 156 participants spent one hour twice a week working with professional dog trainers. Researchers measured changes in stress, mood, sleep…

This Phase 2 trial tested whether KAI-1678, given as a single injection under the skin, can reduce pain in people with spinal cord injury. Only 5 adults with long-term spinal cord injury and chronic pain took part. The study compared KAI-1678 to a placebo to see if it improved pa…

This study tested whether walking training overground with body weight support helps people with chronic spinal cord injury walk better. Fourteen participants were randomly assigned to either overground or treadmill training for four weeks. The goal was to see if the overground a…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study did not test any treatment. Instead, it screened over 1,300 adults with traumatic brain injury (TBI) or post-concussive symptoms to create a database for future research. Participants provided medical history, blood samples, MRI scans, and brain function tests. The goa…

This study investigates whether a non-invasive brain monitoring tool can predict brain injury in extremely low birth weight infants (≤1000 grams) during their first week of life. Researchers will measure brain blood flow using ultrasound and other sensors to see if changes in per…

This completed study tested whether brain wave recordings (event-related potentials) can detect cognitive processing in people with brain injuries, including those with altered consciousness. Researchers compared 320 patients and healthy adults using high-density EEG. The goal wa…

This study tested two different robotic exoskeletons—one that balances itself and one that requires the user to balance—in 6 people with spinal cord injury. Researchers measured how fast and far participants could walk with each device, along with muscle activity and user feedbac…

This study looked at whether the ratio of urea to creatinine in urine can help identify malnutrition in intensive care patients with brain injury. Malnutrition is common in the ICU and raises the risk of infections. Researchers measured this ratio in 309 adults and tracked six ty…

This study looked at how receiving rehabilitation services at home (telerehabilitation) versus in a clinic affects the well-being and quality of life of people recovering from a traumatic brain injury. Five participants were followed for four months, completing questionnaires abo…

This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal …

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study looked at blood and saliva samples from 260 people, including those with traumatic brain injuries, to find protein markers that appear before dangerous pressure builds up inside the skull. The goal is to see if a simple blood test could warn doctors early. No treatment…

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This study looked at 21 adults with COVID-19 who had neurological symptoms like loss of smell, headache, or memory problems. Researchers used MRI scans to find brain changes linked to the virus. The goal was to better understand how COVID-19 can affect the brain, not to test a tr…

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This completed study tested a standard way to select seriously brain-injured patients who might become brain dead within 48 hours. Researchers tracked 83 patients in intensive care to see how many progressed to brain death. The goal was to improve the process for organ donation c…

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

Researchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…

This study looked at how different amounts of mannitol, a medicine used to reduce brain swelling, change blood osmolarity (a measure of blood thickness) in people with traumatic brain injury. Researchers observed 64 patients aged 18-40 with mild to moderate head injuries. The goa…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at how heading a soccer ball changes the brain and whether wearing a mouthguard makes a difference. Twenty-one male soccer players did 10 headers in two sessions—once with a mouthguard and once without. Before and after, they had brain scans, cognitive tests, an…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study checks whether a simple six-minute pegboard and ring test is a valid and reliable way to measure upper body exercise capacity in people with spinal cord injury. Researchers will compare the pegboard results with standard strength and function tests in 34 adults who use…

This study developed and tested a program to help nurses better support relatives of patients with acquired brain injury or malignant brain tumors. The program included nurse training, a dialog tool, a peer support list, videos, and documentation guidelines. Researchers tested it…

This study looked at 98 people with severe traumatic brain injury who needed a breathing tube. Researchers compared two ways of giving nutrition: a new method called Intermittent Oro-esophageal Tube Feeding (IOE) versus the standard Nasogastric Tube Feeding. They measured blood n…

This study tested a new robotic device called REACTION that combines an exoskeleton and a gait trainer to help people with stroke or spinal cord injury improve walking and balance. Seven participants completed two sessions of walking and balance tasks, followed by an interview. T…

This study looked at whether robotic gait training helps people with spinal cord injury walk better compared to standard walking therapy. 115 patients in inpatient rehab took part. The goal was to measure improvements in walking ability and speed.

This pilot study tested a web-based tool designed to improve communication and decision-making between doctors and families of patients with severe acute brain injuries, such as stroke or traumatic brain injury. The tool helps prepare families for their role as decision-makers an…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study tested whether a special ultrasound with a contrast agent (DEFINITY®) can measure blood flow in the spinal cord during surgery for acute spinal cord injury. 27 patients received the contrast agent while surgeons performed routine decompression. The goal was to see if t…

This study looked at 22 adults with spinal cord injury to understand whether anxiety or physical discomfort causes changes in heart rate and blood pressure during bladder catheterization. Participants either did the procedure themselves or had a nurse do it, with some not knowing…

This study looked at whether tiny molecules in the blood, called microRNAs, can help tell if someone with a mild head injury has actual brain damage visible on a CT scan. Researchers took blood samples from 155 people with mild traumatic brain injury and compared those with and w…

This study looked back at 170 adults with chronic neck pain from whiplash injuries to compare two treatments: radiofrequency (a nerve-blocking procedure) and neck fusion surgery. Researchers reviewed medical records from a 20-year period to see which treatment provided better pai…

This study tested whether a gentle electrical stimulation on the ear (taVNS) can improve how the heart and nervous system respond during exercise in people with chronic spinal cord injury. 35 adults completed two exercise sessions—one with real stimulation and one with a sham (fa…

This study looked at whether a low-field MRI (0.23-T) is safe and practical for patients who are on a heart-lung machine after a cardiac arrest. The goal was to see if doctors could use this MRI to find brain injuries early without causing harm. 36 unconscious patients took part,…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at whether a portable brain scanner called fNIRS can safely and effectively measure brain activity in people with chronic traumatic brain injury while they walk on a treadmill with virtual reality. Eight participants completed the session, and researchers checke…

This study tested a simple tool to help family doctors better manage mental health problems after a mild traumatic brain injury (concussion). Over 500 adults who visited an emergency department were enrolled. Doctors received a letter with their patient's mental health screening …

This completed study surveyed 70 women with spinal cord injury to learn about their experiences with fertility, contraception, and pregnancy. Researchers asked closed- and open-ended questions to understand how the injury affects decisions about having children and choosing birth…

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study tracked 69 older adults (age 40 and up) with traumatic brain injury to learn more about their health, frailty, and recovery. Researchers collected data on medications, injuries, and outcomes to find better ways to manage care. No new treatments were tested—the goal was…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study looked at what resilience means for people living with a spinal cord injury. Researchers interviewed 28 adults who had their injury at least one year ago, asking about their experiences and having them fill out surveys. The goal was to find common themes among people a…

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study tested a new training device called an eccentric arm-crank in 12 athletes with spinal cord injury. Over 20 training sessions, participants used the device to build upper body strength and endurance. The goal was to see if the device is practical and effective for impro…

This study tested two types of robot-assisted training for people recovering from a severe brain injury. Ten participants were randomly assigned to either five days of robot-assisted walking training or five days of robot-assisted stepping training, then switched to the other. Th…

This study tested a program called TEaM to improve how doctors and schools support children after a mild traumatic brain injury (concussion). The program included training for doctors and tools to help them communicate with schools and families. Researchers enrolled 101 children …

This small study tested whether it is safe and practical to use two devices together in people with recent spinal cord injury. Eight participants received both a mild electrical stimulator placed on the back and leg, and a low-level laser. The main goal was to see if the equipmen…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study looked at how the calf muscle and Achilles tendon work together during walking in people who have had a stroke or spinal cord injury, compared to healthy individuals. Researchers used ultrasound and motion analysis to measure muscle and tendon lengths in 64 adults. The…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This completed study looked at how the brain controls muscles after a spinal cord injury. Researchers tested 120 people with chronic neck-level injuries to measure nerve signals and motor function. The goal was to better understand how to improve hand and arm movement for daily t…

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This study looked at how walking with a robot (Lokomat) helps people with spinal cord injuries recover movement. Ten patients were assessed before, during, and after training, plus one month later. The goal was to understand how gait improves over time, not to test a new drug or …

This small pilot study looked at whether aerobic exercise can improve memory, attention, and fatigue in people who had a stroke or traumatic brain injury. Twelve participants were split into two groups: one did 30 minutes of aerobic exercise 3-4 times a week for 8 weeks, while th…

This study looked at how blood sugar levels relate to sugar levels in the brain of 14 seriously ill patients with acute brain injury. Researchers used special monitoring tools to measure brain sugar and oxygen. The goal was to better understand this relationship and create a math…

This study looked at swallowing problems in 34 patients with severe traumatic brain injury who are minimally conscious. Researchers used a special X-ray test called videofluoroscopy to see how swallowing works. The goal was to better understand these swallowing disorders, which c…

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study looked at whether ultrasound can measure bladder wall thickness in people with spinal cord injury and how it relates to standard bladder function tests. Researchers studied 116 adults to see if this non-invasive method could help assess bladder health. The goal is to f…

This study tested whether the sedative dexmedetomidine can lower C-reactive protein (CRP), a marker of inflammation, in 25 adults with traumatic brain injury undergoing emergency or planned skull surgery. Patients received either dexmedetomidine or a standard sedative during surg…

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Rese…

Researchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…

This small pilot study looked at whether a ketogenic diet (a high-fat, low-carb diet) is safe and possible for children who have had a moderate to severe traumatic brain injury. Seven children took part, and the main goal was to see if they could stay on the diet for 14 days with…

This completed study surveyed 56 adults with spinal cord injury in Türkiye to find out which everyday activities—like eating, bathing, or using a wheelchair—they value most and how independent they hope to become. Participants rated each activity on a 0–10 scale and stated their …

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study analyzed blood and other samples from 106 adults with recent spinal cord injuries to find molecules linked to better recovery. Researchers measured changes in these molecules before and after rehabilitation and one year after injury. The goal is to identify biological …

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study looked at 94 adults with a recent spinal cord injury to see if keeping their blood pressure at a higher or lower target helped them heal better. Participants were split into two groups: one with a standard blood pressure goal and one with a higher goal, maintained for …

This study looked at how the brain controls eye movements in people aged 11 to 35 who had a concussion 1 to 6 months ago and still have trouble focusing their eyes (convergence insufficiency). Researchers compared these participants to others with eye focusing problems not caused…

This study tested whether a portable, low-field MRI machine could safely scan the brains of children (ages 0-17) who are on ECMO, a type of life support. The goal was to see if the bedside scan was feasible and safe, not to treat or cure any condition. Twenty children participate…

This study looked at whether planning, reminders, and small rewards can help older adults who had a mild or moderate traumatic brain injury (TBI) walk more. 57 participants wore a Fitbit and received weekly calls for 12 weeks. The goal was to see if these simple tools could incre…

This study tested a phone app called MEMI designed to help adults with chronic traumatic brain injury improve their memory. Forty participants used the app to practice remembering words through spaced retrieval exercises. The main goal was to see if the app was easy to use and ac…

This study looked at 68 adults with traumatic brain injury who also have fatigue and trouble thinking. Researchers used machine learning to search for specific genetic markers linked to these symptoms. The goal was to better understand why some people develop these problems after…

This study looked at whether special electrodes placed on the brain or scalp can detect abnormal brain waves called spreading depolarizations in people with traumatic brain injury. Researchers monitored 147 adults in intensive care to see if these methods could work without major…

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This study followed 88 adults with moderate to severe traumatic brain injury for up to 18 months. Researchers used MRI scans and hormone tests to see if hormone deficiencies after injury are linked to lower quality of life. The goal was to better understand these connections, not…

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked back at data from 50 patients with severe brain injuries (from trauma or bleeding) who were treated in the ICU. Researchers analyzed brain blood flow, oxygen levels, and scans to understand how treatments affect the brain and body. The goal is to develop more pe…

This study tested whether a brain-spinal cord-muscle training program can strengthen connections that control movement in people with spinal cord injury. Twenty-one participants completed four months of training using brain stimulation and muscle monitoring. The goal was to see i…

This completed study looked at 80 people with spinal cord injuries to understand how arm, shoulder, and wrist problems relate to their daily lives. Researchers used ultrasound to examine these areas and compared the findings with pain levels and physical exams. The goal was to id…

This study tested whether personalized walking training based on detailed 3D movement analysis works better than standard walking therapy. 63 people with spinal cord damage from injury or multiple sclerosis took part. The goal was to see if customizing exercises to each person's …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This study uses MRI to measure how the brain moves inside the skull during gentle head motions, like turning your head while swimming. Researchers will scan 90 healthy adults aged 18-65 as they perform small, repeated head movements. The goal is to develop a fast imaging method t…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This completed study used MRI scans to see how thinking difficulties appear in the brains of people with spinal cord injury. Fifty-four participants completed cognitive tasks while their brain activity was measured. The goal was to better understand non-motor challenges that ofte…

This study looked at 175 people who had surgery for a serious type of brain bleed called an acute subdural hematoma. Researchers wanted to find out which factors, like age, injury severity, and blood thinner use, best predict how well patients recover over the next year. The goal…

This small study tested whether mild nerve stimulation could increase vaginal blood flow in women with sexual problems, spinal cord injury, or no issues at all. Nine women had a small sensor placed in the vagina to measure blood flow changes during stimulation. The goal was to un…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others who have similar exercise goals. Over one month, 33 participants used the app to find exercise buddies, set goals, and track progress. The goal was to see if the app…

This small study tested whether briefly restricting blood flow to one arm (called remote ischemic conditioning, or RIC) could improve hand function in people with spinal cord injury or ALS. Participants did hand exercises while receiving either active RIC or a sham version. The g…

This study tested whether a virtual reality (VR) program could help children who had a traumatic brain injury (TBI) improve their thinking and problem-solving skills. Fourteen children took part in the trial. Researchers measured their executive functions (like memory and attenti…

This study looked at whether measuring a protein called NfL in the blood or spinal fluid can help doctors manage hydrocephalus, a condition where too much fluid puts pressure on the brain. Researchers studied 41 adults with this condition to see if NfL levels relate to symptoms a…

This study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…

This study looked at 43 adults with incomplete spinal cord injury to see how their own views on safe walking matched their therapists' views and actual walking ability. Researchers measured walking independence, leg strength, balance, and fall risk. The goal is to improve dischar…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study tested whether it is safe to get patients with severe brain injuries out of bed early in the intensive care unit. 22 patients were moved using a special device called the Sara Combilizer, and researchers measured brain oxygen levels and other vital signs. The goal was …

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…

This study followed 35 men with spinal cord injuries over 18 months to see how their sperm quality changes and what factors might cause problems. Researchers measured sperm health, inflammation, and infections from ejaculates collected every 6 months. The goal is to find ways to …

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study looked at how sleep apnea and low oxygen levels affect muscle strength and breathing in people with chronic spinal cord injury. Thirty adults with neck-level spinal cord injuries were tested using hand grip strength and muscle activity measurements. The goal was to und…

This study tested whether robotic training that adjusts errors based on each person's abilities can improve motor learning in healthy adults and people with neurological conditions like stroke. Over 250 participants performed arm tasks with robotic devices while researchers measu…

This study tested a decision aid designed to help adolescents, parents, and clinicians make shared decisions about returning to contact sports after a concussion. Researchers enrolled 110 participants, including teens aged 11-17, their parents, and healthcare providers. The tool …

This study looks at how a robotic body-weight support system called FLOAT affects the way people with incomplete spinal cord injury perform everyday tasks like walking, standing up, and climbing stairs. Researchers measure movement and muscle activity with and without the robot's…

This study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…

This study looked at whether a single session of moderate cycling, done in a lab, with a non-immersive virtual reality screen, or with a full immersive virtual reality headset, could improve thinking speed and multitasking in 24 adults with traumatic brain injury. Participants co…