Can common drugs boost hand recovery after spinal cord injury?
NCT ID NCT05708274
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 trial tested whether three FDA-approved drugs (cyproheptadine, carbidopa-levodopa, and atomoxetine) could improve hand function when combined with hand training exercises in 25 people with chronic spinal cord injury. Participants took a single dose of one drug or a placebo, then performed hand tasks. The study measured dexterity, grip strength, and nerve signals to see if the drugs help strengthen brain-spinal cord connections.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cyproheptadine, carbidopa-levodopa, and atomoxetine
What this could lead to
If successful, this could point toward a drug-assisted therapy to improve hand strength and dexterity after spinal cord injury.
What could go wrong
This is a small, early-phase trial with only 25 participants and single doses, so results may not apply widely or lead to a lasting treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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James J. Peters Veterans Affairs Medical Center
The Bronx, New York, 10468, United States