New hope for spinal cord pain: drug combo shows promise
NCT ID NCT02218203
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received different dose combinations in a random order to see which worked best.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dextromethorphan and lidocaine
What this could lead to
If successful, this could point toward a new drug combination to ease chronic pain after spinal cord injury.
What could go wrong
This is a small, early-phase trial with only 26 people. Results may not apply to everyone, and the drugs may cause side effects or not work better than placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Translational Pain Research, Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States