Can a drug plus nerve training restore leg movement after paralysis?
NCT ID NCT05447676
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The goal was to see if this combination could boost the brain's ability to send signals past the injury site.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dalfampridine (4-AP)
What this could lead to
If successful, this approach could point toward a way to improve leg movement and strength in people with spinal cord injury.
What could go wrong
This is a very early, small trial (26 people) testing a combination of therapies, so results may not be strong or widely applicable. The drug can have side effects like dizziness or urinary tract infections.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shirley Ryan Abilitylab
Chicago, Illinois, 60611, United States