Nervous system injury

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This early-stage trial tests whether injections of tiny particles from umbilical cord stem cells are safe for people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study will enroll 18 adults whose symptoms haven't improved after surgery …

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This study tests a 4-month in-home rehabilitation program called HOME for Us for people who have had a traumatic brain injury (TBI) at least one year ago and their family caregivers. The program involves eight sessions with an occupational therapist, focusing on adapting the home…

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This study tests whether stimulating the vagus nerve while doing rehabilitation exercises can help people with chronic spinal cord injury regain movement and sensation. Twenty participants who completed an earlier trial will receive active VNS paired with exercises targeting the …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This program gives eligible people with acute spinal cord injury early access to the investigational drug elezanumab before it is officially approved. A doctor must decide if the potential benefit outweighs the risks for each patient. The program is only available in certain terr…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug leads to better functio…

This trial tests a procedure called expansile duraplasty, where surgeons open the spinal cord's covering and sew in a patch to give the swollen cord more room. Researchers will compare recovery in 66 adults who receive this extra surgery versus those who get standard care alone. …

This study compares two standard methods for treating severe traumatic brain injury in the ICU. One method monitors only brain pressure, while the other also tracks brain oxygen levels. About 1,094 patients will take part to see which approach leads to better recovery and surviva…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study tests whether adding non-invasive ventilation (a breathing machine) or the drug Buspar to a special rowing exercise program can improve heart and lung fitness in people with high-level spinal cord injury. Seventy participants will exercise for 6 months while receiving …

This study tests a program called NeuroResource Facilitation for offenders with brain injury who are about to be released from prison. The program assigns a facilitator to help them access medical care, job training, and other support services. Researchers will track whether this…

This small study tests a noninvasive method called transcutaneous spinal cord stimulation (scTS) to help children aged 7-12 with chronic cervical spinal cord injury regain hand function. Researchers will find the best placement and strength of stimulation on the neck and lower ba…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study compares a high-tech, computer-controlled knee-ankle-foot brace (C-Brace) to traditional braces in 30 people with spinal cord injury. Participants will train with the device for up to 20 sessions and then use it at home for 3 months. The main goal is to see if the smar…

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either an experimental drug or a placebo within 24 hours of their injury. The main g…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This study tests whether short, mild low-oxygen breathing sessions can improve walking and leg strength in people with a recent spinal cord injury. Over 10 sessions, participants breathe either low-oxygen air or normal air through a mask. The goal is to see if this simple approac…

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study looks at whether giving platelets (cells that help blood clot) to people with severe traumatic brain injuries who are on antiplatelet medications (blood thinners) can improve clotting and stop bleeding in the brain. About 225 adults with certain types of head bleeds wi…

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with moderate to severe TBI and a BMI of 25 or higher will join. The program focuses on healthy eating and physical activity, tracking weight, step count, and blood press…

This study tests a weight-loss program delivered via telehealth, specifically designed for people with traumatic brain injury (TBI). The program is adapted from the Diabetes Prevention Program and addresses unique needs of TBI patients. Researchers aim to see if the program helps…

This study tests an implanted stimulator and sensor that helps people with cervical spinal cord injury regain hand and arm function. Ten participants will use the device to perform everyday tasks like grasping objects. The goal is to improve independence and quality of life.

This study compares two types of brain surgery for people with a severe head injury that causes a blood clot (epidural hematoma) and brain herniation. One surgery removes the clot and a piece of skull to relieve pressure; the other removes the clot without removing skull bone. Th…

This expanded access program gives one patient with a spinal cord injury at the C5-C7 level a single infusion of their own stem cells (HB-adMSCs). The stem cells are taken from the patient's fat tissue and grown in a lab before being given back. The goal is to see if this approac…

This study tested a stem cell treatment for people with long-term spinal cord injuries. It involved three patients who received their own fat-derived stem cells through an IV. The goal was to see if the treatment could safely restore nerve signals and improve sensation or movemen…

This pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests a device called the RISES-T System, which uses mild electrical stimulation through the skin to help people with chronic spinal cord injury improve their mobility and reduce muscle stiffness. Ten participants will try different stimulation techniques while researc…

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

Many people with spinal cord injury struggle with slow bowel emptying and constipation. This study tests whether a small device that delivers gentle electrical pulses to the belly can speed up bowel movements and improve stool consistency. Twelve participants will use the stimula…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This study compares virtual reality exercises to standard physical therapy for improving walking and balance in adults aged 60 and older. Thirty-six participants will either use a VR headset to play movement games or do traditional exercises like tandem walking. Researchers will …

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This study tests whether an implanted spinal cord stimulator can reduce chronic pain and improve rehabilitation outcomes in people with thoracic spinal cord injury. Twenty-five participants will either have the device turned on or off for three months, while both groups continue …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This study tests whether high doses of branched chain amino acids (BCAAs), a type of supplement, can help people aged 11 to 23 recover from a concussion more quickly. Participants receive either a BCAA drink or a placebo for 28 days. The main goal is to see if more people in the …

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This study tests whether a hormone called pregnenolone can improve mental health, thinking, and pain in veterans who had a mild traumatic brain injury (TBI) while serving after 9/11. About 108 veterans will take either pregnenolone or a placebo daily for 8 weeks. Researchers will…

This study aimed to see if a simple mindfulness breathing exercise could improve health and quality of life in people with spinal cord injury. Participants would have done a 10-15 minute guided breathing session three times a week for a month. However, the trial was withdrawn bef…

This early-stage study tests whether a smartphone app and remote training can help military members and active young adults recover from a mild concussion. The goal is to improve symptoms and lower the risk of getting hurt again. About 88 people will participate.

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This study looks at why some people get persistent headaches after a mild concussion and tests a new treatment called repetitive transcranial magnetic stimulation (rTMS). Researchers will measure headache days and blood markers in 62 adults who had a mild brain injury 2-4 months …

This small pilot study is testing whether a daily low dose of naltrexone (4.5 mg) can reduce central neuropathic pain and improve quality of life in 10 adults with traumatic spinal cord injury. Participants take the drug for 12 weeks, and researchers measure pain scores and daily…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This trial tests whether a 10-week online health program called DRIV can help adults with long-term spinal cord injury adopt healthier habits and feel better. Participants attend weekly video group sessions covering exercise, nutrition, stress, and goal-setting. Researchers compa…

This study tests a new way to use deep brain stimulation for people with severe, treatment-resistant chronic pain from stroke, spinal cord injury, or phantom limb pain. Instead of constant stimulation, the device delivers electrical pulses only when the brain senses high pain sig…

This study tests whether a 3-week outpatient rehab program can reduce long-lasting symptoms of traumatic brain injury (TBI) and related conditions like PTSD and depression in 416 veterans and first responders. Participants will complete surveys, and some will also give blood samp…

This study tests whether combining motor skill training with a non-invasive spinal stimulation can improve walking, balance, and strength while reducing muscle spasticity in people with incomplete spinal cord injury. Twenty-eight participants will do a series of standing exercise…

This study tests a type of talk therapy called graded exposure therapy for people who have had a concussion and are still having symptoms. The therapy, delivered by a psychologist over 12 video sessions, helps people gradually face activities they have been avoiding due to fear o…

This study looks at whether using a powered exoskeleton to walk can improve quality of life for people with spinal cord injury. Eighteen participants will either use the device at home or in a clinic over 24 months. Researchers will measure changes in well-being and compare costs…

This study tests whether brief periods of breathing low oxygen can improve leg strength and walking in people with chronic spinal cord injury. Thirty adults with incomplete spinal cord injury will inhale low oxygen for short sessions over time. Researchers will measure walking en…

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This study looks at whether nutrition education and one-on-one counseling can reduce chronic pain in people with spinal cord injury. Thirty adults will attend monthly sessions for four months, either in person or online. Researchers will measure changes in pain intensity and nerv…

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests whether an 8-week group exercise class done over video can improve psychological and social well-being in people with spinal cord injury. The class is tailored for wheelchair users and co-led by someone with lived experience. Researchers will measure changes in m…

This study looks at whether a program called LearningRx can improve thinking skills, daily life function, and work confidence in adults who have had a traumatic or acquired brain injury, including from COVID-19. About 30 participants will complete cognitive exercises and be teste…

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This study tests whether 8 weeks of acceptance and commitment therapy (ACT) delivered via Zoom can help reduce depression in people with spinal cord injuries. 140 participants with mild or worse depressive symptoms will be randomly assigned to either ACT or a wait-list that conti…

This study tests whether adding mild electrical stimulation to the spinal cord (TSCS) to exoskeleton training helps people with incomplete spinal cord injury walk better. 30 participants within a year of injury will receive 24 training sessions. Researchers will measure walking s…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study tests whether a gentle electrical current (TENS) applied to the lower back can reduce muscle stiffness and improve movement in people with spinal cord injuries. Forty adults with injuries between the neck and mid-back will either receive TENS for two months or wait two…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study looks at whether chiropractic care can help young athletes (ages 18-40) recover from sports-related concussions. Researchers will measure attention, balance, mood, and other functions before and after treatment. The goal is to see if this approach is practical and wort…

This pilot study aimed to test whether a virtual reality (VR) cooking simulation could improve arm movement and daily function in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdr…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a special light box each morning, and researchers track changes in sleep quality, mood, thinking, and blood markers. The goal is to find…

This study tests a method called conditioning open-label placebo (COLP) to help patients with spinal cord injury, multiple injuries, or burns use fewer opioids while still getting the same pain relief. About 66 adults in intensive rehab will receive a placebo alongside their regu…

This study tests a gentle brain stimulation method called tDCS in 41 veterans who had a mild traumatic brain injury over a year ago. Participants receive either real or fake stimulation while doing memory exercises. The goal is to see if tDCS can improve thinking skills and daily…

This study tests a new type of magnetic brain stimulation in 15 adults who have had a mild traumatic brain injury and still have symptoms like headaches or trouble thinking. Participants get 30 short treatment sessions and detailed MRI scans before and after. The goal is to see i…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study tests whether 36 sessions of a computer-based brain training program, called PATH neurotraining, followed by digit memory exercises, can improve working memory, processing speed, and attention in people who have had a mild traumatic brain injury (concussion). The train…

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part.

This study was designed to observe how patients with acute brain injury are taken off mechanical ventilation (breathing machines) in the ICU. It planned to include adults with brain injury who needed a ventilator for at least 24 hours, but the study was withdrawn before enrolling…

This study interviews 120 people—patients, relatives, and healthcare staff—to better understand what 'person-centered' means in rehabilitation. Researchers will use these insights to develop a tool that measures how well rehab services focus on individual needs. The goal is to im…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study follows 300 people who had a traumatic brain injury (TBI) for at least two years after their injury. Researchers want to see how their recovery changes over time and test a blood marker that may show brain damage. The goal is to better understand the long-term effects …

This study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…

This study looks at how different levels of traumatic brain injury (TBI) affect children's thinking, balance, and ability to do everyday tasks. Researchers will test 48 children aged 8 to 12 with mild to moderate TBI using standard assessments. The goal is to understand the links…

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study tests a new, low-cost device that creates controlled slips while people with incomplete spinal cord injuries walk on it. The goal is to measure how their balance changes, both standing still and moving. Ten participants who can walk without aids will be observed to bet…

This study was designed to test a program that helps caregivers of people with traumatic brain injury improve their problem-solving skills. It planned to enroll adults aged 19 and older, but was withdrawn before any participants joined, so no results are available.

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This observational study looks at 300 adults with severe traumatic brain injury to see how low brain oxygen levels affect certain proteins in the blood, known as biomarkers. Researchers will measure these proteins to better understand brain damage and recovery. The study does not…

This study tests an 8-week online group program called Living Longer and Stronger with SCI, designed to help people with spinal cord injury improve their physical, mental, and social health as they age. Participants set health goals and make weekly action plans with support from …

This study asks 30 adults with spinal cord injury about their exercise habits and what they would want in a physical activity program. Researchers will use surveys and interviews to learn what helps people start and keep exercising. The goal is to design better exercise programs …

This study is working to create a prediction model specifically for children with moderate to severe traumatic brain injury (TBI). Currently, doctors use models designed for adults, which may not be accurate for kids. Researchers will analyze data from 2000 children to develop a …

This study follows 250 former NFL players and healthy volunteers aged 50-70 over 5 years. Researchers use brain scans, blood tests, and thinking/memory assessments to understand how concussions and repeated head impacts affect long-term brain health. The goal is to gather informa…

This study looks at whether a special computer tool can help doctors better care for children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers wil…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study tests a program called BETTER that helps adults with traumatic brain injury and their families after they leave the hospital. The program provides education, training, and therapy to support recovery at home. Researchers will compare the program to usual care in 500 pa…

This study tests a new way to measure how children move their arms using a special camera system that tracks reflective markers placed on the skin. Researchers will check if the method is reliable and easy to use in both healthy children and those with arm movement problems. The …

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study compares three different therapy approaches to help people with cervical spinal cord injury improve arm, hand, and trunk control. Ninety-nine participants will complete 40 therapy sessions over 8 weeks, with follow-up at 12 weeks. The goal is to find which method works…

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…

This early-phase study at the Cleveland Clinic is testing whether combining a type of brain stimulation (paired neurostimulation) with hand training on one side can improve hand movement and dexterity on both sides in people with cervical spinal cord injury. Seventeen participant…

This study uses repeated MRI scans to track brain injury and growth in very preterm babies (born before 33 weeks) during their NICU stay. Researchers will also test a program called SENSE-plus, which involves daily gentle sensory activities like touch and sound, to see if it help…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study tracks 750 teens aged 13-18 with mild concussions to see if changes in their saliva can predict how long symptoms last. Researchers will check for persistent symptoms 30 days after injury. The goal is to find biological markers that help doctors personalize recovery pl…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study looks at whether non-invasive spinal cord stimulation, combined with breathing, arm, or trunk training, can improve lung and breathing muscle function in people with spinal cord injuries. 36 adults with injuries at or above the T5 level are participating. The goal is t…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study looks at whether a simple ultrasound of the brain's blood flow can safely identify mild traumatic brain injury patients who can go home right away instead of staying in the hospital for observation. About 550 adults with mild head injuries will be randomly assigned to …

This study follows 50 adults with incomplete cervical spinal cord injuries to see how well certain tests capture their recovery over 6 months. Researchers will track things like movement, sensation, and balance to find the best ways to measure improvement. The goal is to make fut…

This study compares two treadmill tests—the Buffalo Concussion Treadmill Test and a modified dynamic exertion test—in teens aged 14-17 who had a sport-related concussion within the past 14 days. The goal is to see which test better measures symptoms like headache and dizziness, a…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at whether spontaneous eye blinking can help doctors understand the level of consciousness and attention in people with severe acquired brain injury. Researchers will record eye blinks using simple sensors while patients rest or listen to sounds. The goal is to d…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

This study from Mayo Clinic will follow 4,000 athletes aged 12-30 to find better ways to diagnose concussions on the spot and set safe return-to-play rules. Researchers will also test if neck and vision training can help prevent brain injuries. The goal is to use simple tests and…

This study tests a training program for occupational therapists who work with adults who have had a brain injury. The goal is to help therapists better spot and treat anxiety and depression in their patients. Twenty therapists will take part, and researchers will see if they star…

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study follows 52 elite junior ice hockey players over a season to understand how head impacts affect the brain and body. Players wear helmet sensors to record impacts, plus heart rate monitors and cognitive tests to detect subtle changes. The goal is to improve concussion de…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study follows 150 adults undergoing back-of-the-neck and upper spine surgery with metal screws and rods (posterior fixation) for injuries, tumors, or worn-out discs. Researchers track complications, X-ray results, and patient-reported pain over time. The goal is to better un…

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-ap…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study tested a new device that measures blood flow, pressure, and temperature inside the brain, while also draining fluid. It was designed for patients with serious brain injuries who already need standard monitoring. Only one person took part, and the goal was to see if the…

This study tests a program to help people with traumatic brain injury (TBI) who are leaving prison avoid returning to jail. 102 participants will be randomly assigned to either the new program or standard services. The program provides support and teaches coping skills to reduce …

This study looks at how common mild brain injuries are in Czech soldiers during tough training like parachute jumps and shooting. Researchers will test blood for injury markers and use wearable sensors to measure head impacts. The goal is to find risks and create ways to protect …

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study tests a 12-session teletherapy program called ICARE for people with traumatic brain injury (TBI) and their care partners. The program teaches emotion recognition from facial expressions and empathy skills through role-playing. Researchers want to see if it's practical …

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study is looking at whether changes in RNA found in saliva can help predict how long concussion symptoms will last in children aged 5 to 21. Researchers will collect saliva samples and track symptoms like dizziness and balance problems. The goal is to better understand recov…

This study is testing whether a short educational video that gives positive reassurance can improve recovery in people with mild traumatic brain injury (mTBI). Researchers will enroll 229 participants aged 13-21 who were diagnosed with mTBI in the emergency department. The goal i…

This study looks at early factors that might predict how well people recover after a traumatic spinal cord injury. Researchers will examine blood pressure management, pain medications, and biological markers from 800 patients. The goal is to find patterns that help doctors person…

This study looks at children aged 3 to 16 with severe head injuries to understand why some have poor outcomes. Researchers are testing extra monitors that track oxygen and chemical changes in the brain, which are already used safely in adults. The goal is to gather information th…

This study looks at 600 adults who take blood thinners and have a mild head injury but a normal first brain scan. Researchers want to know how often a delayed brain bleed happens within 24 hours and up to 4 weeks after the injury. They also track risks like blood clots or confusi…

This study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…