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Could letting fever run its course help brain injury patients?

NCT ID NCT07709325

Knowledge-focused Sponsor: Odense University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This pilot study explores whether it is safe and practical to allow body temperature to rise to 39.5°C (permissive hyperthermia) in critically ill patients with severe brain injury, instead of aggressively treating fever. Twenty patients on ventilators with brain monitoring will be placed in one of two groups: one where fever is kept below 37.5°C, and one where fever is allowed up to 39.5°C. The goal is to see if working with the body's natural fever response is feasible without raising brain pressure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Allowing body temperature up to 39.5°C (permissive hyperthermia) versus standard fever control below 37.5°C
What this could lead to
If safe, this approach could change how fever is managed in brain injury, potentially reducing the need for aggressive cooling.
What could go wrong
This is a very small pilot study (20 people) testing feasibility only, not effectiveness. Allowing higher temperature might increase brain pressure or cause harm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Apr 2026

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Severe acute brain injury. * Requirement for: Mechanical ventilation Sedation Intracranial pressure (ICP) monitoring Exclusion Criteria: * Pregnancy * Moribund patients or patients in whom withdrawal of active treatment is anticipated

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Conditions

The condition(s) this trial relates to.

brain injury Fever

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fever

Contacts and locations

Locations

  • Neurointensiv care

    Odense C, 5000, Denmark

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