Blood test may spare elderly from unnecessary brain scans after mild head injury

NCT ID NCT05425251

Completed Diagnosis Sponsor: Hospital Universitario 12 de Octubre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can safely tell doctors when an older adult with a mild head injury does not need a CT scan. Over 2,200 participants aged 65 and older were enrolled. The goal is to reduce unnecessary radiation and costs while still catching serious brain injuries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Blood test measuring GFAP and UCH-L1 proteins
What this could lead to: If successful, this could reduce unnecessary CT scans and radiation exposure in elderly patients with mild head injury.
What could go wrong: This is a completed diagnostic study, not a treatment trial. The biomarkers may not be accurate enough in elderly patients with other health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MILD TRAUMATIC BRAIN INJURY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Brain Concussion traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

CHU Clermont-Ferrand

Clermont-Ferrand, France
CHU Grenoble-Alpes

Grenoble, France
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hôpital Edouard HERRIOT

Lyon, France
Hôpital Lyon Sud HCL

Lyon, France
Klinikum rechts der Isar

Munich, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.