Blood test may spare elderly from unnecessary brain scans after mild head injury
NCT ID NCT05425251
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can safely tell doctors when an older adult with a mild head injury does not need a CT scan. Over 2,200 participants aged 65 and older were enrolled. The goal is to reduce unnecessary radiation and costs while still catching serious brain injuries.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Blood test measuring GFAP and UCH-L1 proteins
What this could lead to
If successful, this could reduce unnecessary CT scans and radiation exposure in elderly patients with mild head injury.
What could go wrong
This is a completed diagnostic study, not a treatment trial. The biomarkers may not be accurate enough in elderly patients with other health conditions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Clermont-Ferrand
Clermont-Ferrand, France
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CHU Grenoble-Alpes
Grenoble, France
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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Hospital Universitario 12 de Octubre
Madrid, Madrid, 28041, Spain
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Hôpital Edouard HERRIOT
Lyon, France
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Hôpital Lyon Sud HCL
Lyon, France
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Klinikum rechts der Isar
Munich, Germany