New drug hopes to restore arm movement after spinal injury

NCT ID NCT04683848

Completed Disease control Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called MT-3921 (Unasnemab) in 72 people with recent severe neck spinal cord injuries. The goal was to see if it could improve arm and hand function better than a placebo. Participants received the drug or placebo by IV over 6 months, and their motor scores were measured.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MT-3921 (Unasnemab)
What this could lead to: If it works, this could point toward a treatment that improves arm and hand function after a severe neck spinal cord injury.
What could go wrong: This is a small, early-phase trial with only 72 people. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL CORD INJURY

Contacts and locations

Locations

Augusta University

Augusta, Georgia, 30912, United States
Brooke Army Medical Center in San Antonio

Houston, Texas, 78234, United States
Carilion Clinic

Roanoke, Virginia, 24014, United States
Carolinas Rehabilitation

Charlotte, North Carolina, 28203, United States
Gifu University Hospital

Gifu, Gifu, 501-1194, Japan
Hokkaido Spinal Cord Injury Center

Bibai-shi, Hokkaido, 072-0015, Japan
Japan Organization of Occupational Health and Safety SPINAL INJURIES CENTER

Izuka-shi, Fukuoka, 820-8508, Japan
Japanese Red Cross Kobe Hospital

Kobe, Hyōgo, 651-0073, Japan
Medical College of Wisconsin - Froedtert Hospital

Milwaukee, Wisconsin, 53226, United States
Murayama Medical Center

Musashimurayama-shi, Tokyo, 208-0011, Japan
NSHA-Queen Elizabeth II Health Sciences Centre

Halifax, Nova Scotia, B3H3A7, Canada
National Hospital Organization Kumamoto Medical Center

Kumamoto, Kumamoto, 860-0008, Japan
Oregon Health and Science University - Center for Health & Healing

Portland, Oregon, 97239, United States
Saint Louis University Hospital

St Louis, Missouri, 63110, United States
Spectrum Health

Grand Rapids, Michigan, 49503, United States
Tallahassee Neurological Clinic

Tallahassee, Florida, 32308, United States
The Ottawa Hospital

Ottawa, Ontario, K1Y4E9, Canada
The University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of California Irvine

Orange, California, 92868, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Kentucky

Lexington, Kentucky, 40536, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

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