Can antioxidants help older brains heal after a concussion?

NCT ID NCT04291066

Completed Symptom relief Sponsor: HonorHealth Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving N-Acetylcysteine (a supplement) along with multivitamins and minerals can help older adults (60+) recover from a traumatic brain injury. The goal was to see if it reduces thinking, emotional, and physical symptoms like headaches or memory problems. Researchers measured symptoms at the start, after 7 days, and after 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: N-Acetylcysteine and multivitamins/minerals
What this could lead to: If it works, this could point toward a simple, safe treatment to reduce post-concussion symptoms in older adults after a traumatic brain injury.
What could go wrong: This is a small, early-phase study with only 92 participants, so results may not apply to everyone. The treatment may not show clear benefits over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

HonorHealth Deer Valley Medical Center

Phoenix, Arizona, 85027, United States
HonorHealth John C. Lincoln Medical Center

Phoenix, Arizona, 85020, United States

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