Can emotional brain waves wake the unresponsive?

NCT ID NCT06204172

Completed Symptom relief Sponsor: IRCCS Centro Neurolesi Bonino Pulejo Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a new device called Intensive Neurowave Emotional Stimulation (INES) in 40 people with disorders of consciousness after severe brain injury. The experimental group received multisensory stimulation with emotionally meaningful audio-visual content, while the control group got traditional stimulation. Researchers measured cognitive and motor function improvements over four weeks and at a one-month follow-up.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intensive Neurowave Emotional Stimulation (INES) device
What this could lead to: If it works, this could point toward a new rehabilitation method to help people with disorders of consciousness regain cognitive and motor function.
What could go wrong: This is a very small pilot study with only 40 participants, so results may not apply to everyone. The treatment is experimental and may not lead to meaningful improvement.

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Conditions

The condition(s) this trial relates to.

brain injury Consciousness Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DISORDERS OF CONSCIOUSNESS

Contacts and locations

Locations

IRCCS Centro Neurolesi Bonino Pulejo

Messina, Italy/Messina, 98124, Italy

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