DISORDERS OF CONSCIOUSNESS

This trial tests whether a gentle electrical stimulation applied to the ear—called transcutaneous auricular vagus nerve stimulation—can help people recover consciousness after surgery for a spontaneous brain hemorrhage. The study will include 160 adults aged 18 to 75 who remain i…

This study tests a special helmet that sends low-intensity ultrasound waves to deep brain regions in people with disorders of consciousness after severe brain injury. The goal is to see if this approach is safe and can temporarily improve arousal or responsiveness. Ten participan…

This early study tests whether implanting electrodes deep in the brain (thalamus) can safely help people with long-term disorders of consciousness. Only 2 participants will be enrolled, and the main goal is to check safety and see if awareness improves using a standard behavioral…

This study looks at whether spontaneous eye blinking can help doctors tell the difference between two types of consciousness disorders: unresponsive wakefulness syndrome and minimally conscious state. Researchers will measure blinking patterns in 70 patients across 8 European cen…

This study explores whether measuring brain activity during a brief rectal balloon inflation can help doctors tell the difference between patients who are minimally conscious and those who are unresponsive. Researchers will record EEGs in 45 patients with disorders of consciousne…

This study tests a new, non-invasive brain stimulation method called theta-burst patterned temporal interference stimulation (tTIs) to see if it can improve awareness in people with disorders of consciousness, such as vegetative or minimally conscious states. About 136 adults wil…

This study explores whether a safe, non-invasive device that stimulates a nerve in the ear can improve consciousness in people who are in a vegetative or minimally conscious state after a severe brain injury. Twenty participants will receive the stimulation twice daily for 10 day…

This large registry study tracks 2,000 adults in China with severe spontaneous brain hemorrhage to compare outcomes of emergency surgery versus conservative (non-surgical) treatment. It focuses on patients who take long-term antiplatelet drugs (like aspirin) to see if surgery is …

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at whether people with disorders of consciousness (like coma or minimally conscious state) can form and recall memories. Researchers will use brain wave (EEG) and skin sensors to detect memory activity that can't be seen through behavior alone. The goal is to bet…