Diabetes drug metformin could help heal spinal cord injuries

NCT ID NCT07272967

Not yet recruiting Disease control Sponsor: Badr University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether metformin, a common diabetes medicine, can help people recover after a spinal cord injury. The drug may reduce scar tissue that blocks nerve healing. Researchers will give metformin or a placebo to 34 adults with recent thoraco-lumbar spinal cord injury and measure their neurological recovery and pain levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin (Glucophage) 1000 mg tablets
What this could lead to: If it works, this could point toward a new, safe way to improve nerve recovery and reduce pain after spinal cord injury.
What could go wrong: This is a small early-phase trial with only 34 participants, so results may not apply widely. Metformin's effect on spinal cord injury is still unproven in humans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gliosis spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL CORD INJURY(SCI)

Contacts and locations

Locations

Neurosurgery department at Menoufia University hospitals at Menoufia University.

Shibīn al Kawm, Menoufia, 32817, Egypt

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