Could a simple spray prevent dangerous blood pressure spikes after spinal injury?
NCT ID NCT05635851
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. The study measures blood pressure changes and symptoms to see if the drug is safe and effective in real-world use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- glyceryl trinitrate (nitric oxide donor) sublingual spray
- What this could lead to
- If it works, this could offer a simple, at-home way to prevent dangerous blood pressure spikes during bowel care for people with spinal cord injury.
- What could go wrong
- This is a small, early-phase trial with only 26 participants, so results may not apply to everyone. The drug may not work as expected or could cause side effects like low blood pressure or headache.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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