Could a simple shot prevent brain bleeding after a fall?

NCT ID NCT04521881

Recruiting now Disease control Sponsor: London School of Hygiene and Tropical Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether a single injection of tranexamic acid, given within 3 hours of a mild head injury, can reduce brain bleeding, disability, and death in adults aged 50 and older. The study aims to enroll 5,000 participants and compares the drug to a placebo. If successful, it could offer an easy, low-cost way to improve outcomes after common falls.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid
What this could lead to: If it works, this could provide a simple, early treatment to prevent serious complications like brain bleeding and disability after a mild head injury in older adults.
What could go wrong: This is a large trial, but the benefit may be small or not apply to everyone. Tranexamic acid can cause blood clots in some people, so risks need careful monitoring.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

St George's Hospital
RECRUITING

London, London, SW17 0QT, United Kingdom
The Royal London Hospital
RECRUITING

London, London, E1 1FR, United Kingdom

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