Spinal stimulation and exercise may restore hand function in paralysis

NCT ID NCT05423600

Recruiting now Disease control Sponsor: Virginia Commonwealth University Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study investigates whether a home-based, telehealth-supported program combining blood flow restricted exercise and transspinal stimulation can improve hand and arm function in people with chronic, incomplete tetraplegia. Participants will perform task-specific activities while receiving either real or sham spinal stimulation. The goal is to see if this combination leads to better grip strength, hand coordination, and sensory perception compared to exercise alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Blood flow restriction enhanced neuromuscular electrical stimulation and transspinal stimulation
What this could lead to: If successful, this approach could offer a home-based therapy to improve hand and arm function in people with tetraplegia, enhancing independence.
What could go wrong: This is an early-stage study with a small number of participants, so results may not apply to everyone. The therapy requires a companion for assistance, which may limit accessibility.

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Conditions

The condition(s) this trial relates to.

quadriplegia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TETRAPLEGIA/TETRAPARESIS

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Richmond VA Medical Center
RECRUITING

Richmond, Virginia, 23249, United States
Sheltering Arms Physical Rehabilitation Centers
RECRUITING

Richmond, Virginia, 23226, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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