Blood tests could guide oxygen therapy for severe brain injury

NCT ID NCT04855396

Recruiting now Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing different doses of hyperbaric oxygen. The goal is to find reliable markers that could make future treatment more personalized and clinical trials more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy
What this could lead to: If successful, this could help doctors tailor hyperbaric oxygen therapy to individual patients and make future clinical trials more efficient.
What could go wrong: This is an observational study that does not directly test a treatment. The findings may not lead to improved outcomes or may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic Charcot-Marie-Tooth disease type 1F traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Detroit Receiving Hospital
RECRUITING

Detroit, Michigan, 48201, United States
Duke University Hospital
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Hamilton General Hospital
SUSPENDED

Hamilton, Ontario, L8L 2X2, Canada
Hennepin County Medical Center
RECRUITING

Minneapolis, Minnesota, 55415, United States
OSU Wexner Medical Center
SUSPENDED

Columbus, Ohio, 43210, United States
St. Mary's Medical Center
SUSPENDED

West Palm Beach, Florida, 33407, United States
UCSD Medical Center - Hillcrest Hospital
RECRUITING

San Diego, California, 92103, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky Hospital
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Nebraska Medical Center
SUSPENDED

Omaha, Nebraska, 68198, United States

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