Brain zaps could help paralyzed patients walk again

NCT ID NCT03053791

Recruiting now Disease control Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking ability. The study is based on promising results in rats, but it is too early to know if it will help humans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep brain stimulation
What this could lead to: If it works, this could point toward a new way to help people with spinal cord injuries walk better.
What could go wrong: This is a very early, tiny trial with only 5 people. It is focused on safety, not proof of effectiveness. The approach may not work in humans as it did in rats.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

paraplegia spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL CORD INJURY

Contacts and locations

Locations

Balgrist University Hospital
RECRUITING

Zurich, 8008, Switzerland

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Other studies related to the condition(s) this trial covers.