Spine surgery breakthrough? simple drug pour may cut blood loss and transfusions
NCT ID NCT02314988
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether pouring tranexamic acid (TXA), a drug that helps blood clot, directly into the surgical wound during spine surgery can reduce bleeding and the need for blood transfusions. About 252 adults with spinal injuries or deformities will be randomly assigned to receive either TXA or a placebo (salt water) during their operation. Researchers will track blood loss, transfusion rates, and complications over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tranexamic acid (TXA)
What this could lead to
If it works, this could offer a simple, low-cost way to reduce blood loss and transfusion needs during spine surgery, potentially lowering infection risks.
What could go wrong
This is a mid-stage trial with 252 participants, so results may not apply to all patients. There is also a small risk of blood clots or other complications from the drug.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
Contact
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NYP/The Allen Hospital - CUIMC
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
Contact
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Norton Leatherman Spine Center
RECRUITINGLouisville, Kentucky, 40202, United States
Contact
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University of California San Francisco Medical Center
RECRUITINGSan Francisco, California, 94149, United States
Contact