Spine surgery breakthrough? simple drug pour may cut blood loss and transfusions

NCT ID NCT02314988

Recruiting now Disease control Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether pouring tranexamic acid (TXA), a drug that helps blood clot, directly into the surgical wound during spine surgery can reduce bleeding and the need for blood transfusions. About 252 adults with spinal injuries or deformities will be randomly assigned to receive either TXA or a placebo (salt water) during their operation. Researchers will track blood loss, transfusion rates, and complications over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid (TXA)
What this could lead to: If it works, this could offer a simple, low-cost way to reduce blood loss and transfusion needs during spine surgery, potentially lowering infection risks.
What could go wrong: This is a mid-stage trial with 252 participants, so results may not apply to all patients. There is also a small risk of blood clots or other complications from the drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

spinal injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL DEFORMITY SPINAL INJURIES

Contacts and locations

Locations

Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
NYP/The Allen Hospital - CUIMC
RECRUITING

New York, New York, 10032, United States
Norton Leatherman Spine Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of California San Francisco Medical Center
RECRUITING

San Francisco, California, 94149, United States

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