Injury

This study tested a dramatic approach: rapidly cooling trauma patients whose hearts had stopped from severe bleeding. Doctors flushed ice-cold saline into the aorta to induce deep hypothermia, then performed emergency surgery to stop the bleeding before slowly rewarming the patie…

This study tested whether applying 0.25% timolol gel (a beta-blocker eye drop used for glaucoma) to skin grafts could improve healing and appearance after skin cancer surgery. Researchers planned to enroll 82 patients but stopped early with only 10 participants. The goal was to s…

This study looked at a shoulder implant used to treat pain and joint problems from conditions like arthritis, fractures, and rotator cuff tears. It involved 67 adults who received the implant and tracked how long it lasted and any side effects over 10 years. The goal was to confi…

This study tested a new device called the Vertebral Implant PEEK (VIP) for people with spine fractures due to osteoporosis. The goal was to see if the implant is safe and helps repair the broken bone. The study included 23 adults aged 50 and older with recent fractures that did n…

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study tested a special cement that mimics natural bone to repair broken vertebrae in adults aged 18 to 65. The cement is designed to be absorbed by the body and replaced with new bone over time. Only 4 people took part before the study was stopped early. The goal was to see …

This study tested whether the statin drug rosuvastatin, taken daily with supplements, could improve bone density and reduce heart disease risk in adults with long-term spinal cord injury. Only 8 people enrolled before the trial was stopped early. Participants received either rosu…

This study tested a new bone grafting material called SurgiFill™ in 60 people with broken thigh or shin bones. The goal was to see if it helps bones heal faster and safely. The study was stopped early, so results are limited.

This study tested a special curved rod implant designed to fix broken pelvic and hip socket bones. It included 53 adults who had already received the implant. Researchers tracked whether patients needed more surgeries and how well they could move and bear weight afterward.

This study looked at the TITAN Reverse Shoulder System, a device used to replace the shoulder joint in people with severe arthritis and a torn rotator cuff. The goal was to see if it relieves pain and improves movement. About 151 people were planned to take part, but the study wa…

This study aimed to see if the steroid dexamethasone could help people with traumatic brain injury who had brain contusions and swelling. It planned to enroll 600 adults, giving them a short course of dexamethasone or a placebo. The main goal was to measure recovery using the Gla…

This study tested a drug called VS-01 for people with severe confusion caused by liver disease (overt hepatic encephalopathy). The trial planned to enroll many participants but was stopped early after only 3 people joined. Researchers wanted to see if VS-01 could help patients re…

This study tested a single dose of a drug called BE1116 (a 4-factor prothrombin complex concentrate) in people with traumatic injuries and severe bleeding. The goal was to see if it could improve survival within 6 hours compared to a placebo. The trial was stopped early after enr…

This study tested lithium disilicate crowns made with CAD/CAM technology in 8 adults with cavities or damaged teeth. The crowns were placed using different adhesive methods to check for sensitivity and quality. The trial was terminated early, so the findings are limited.

This pilot study tested whether a new imaging technique called shear-wave elastography (SWE) combined with MRI can detect radiation-induced injury to the uterus. Researchers recruited women who had pelvic radiation before age 40 and compared their scans to healthy controls. The g…

This study tested whether a special 3D camera (DermaMonitor) could accurately measure the size and depth of burn wounds. Researchers compared the camera's measurements to those made by doctors. The study was stopped early and included only 8 adults with burns. The goal was to see…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This study looked at whether ultrasound can accurately diagnose ankle injuries in children aged 5 to 17. Researchers compared ultrasound results to MRI, which is considered the gold standard. The goal was to see if ultrasound could be a faster, radiation-free way to diagnose inju…

This study tested whether giving fish oil and vitamin D soon after a burn injury could prevent chronic pain. It included 24 adults with burns covering less than 30% of their body. The trial was stopped early, so results are limited, but the goal was to find a safe, low-cost way t…

This study tested a special seat cushion (GASPARD®) that measures pressure and sends alerts to a smartphone to help prevent pressure sores in people with spinal cord injuries. The trial included 134 participants who used manual wheelchairs. Unfortunately, the study was terminated…

This study tested whether a silicone adhesive dressing called Embrace can improve the look of scars after skin surgery. Half of each surgical wound was treated with the device, the other half with standard care. The trial was stopped early, so results are limited, but the goal wa…

This pilot study tested a 24-hour IV infusion of brexanolone in 10 adult women with PTSD from non-military trauma. The goal was to see if it could reduce PTSD symptoms and lead to remission by 12 weeks. The trial was terminated early, so results are limited.

This small pilot study aimed to see if it's possible to start neck therapy earlier for people with concussion and neck pain. Only 2 people enrolled before the study was stopped. The main goal was to check if the study process worked, not to measure how well the treatment helped s…

This study tested a music therapy program for adults with acquired brain injury, aiming to improve their comfort and well-being. Researchers worked with 27 hospitalized patients to see if group music sessions could help them feel better. The study was stopped early, so results ar…

This study looked at whether a non-invasive brain stimulation method called tDCS, when added to standard physical therapy, could improve arm and hand function in people with recent spinal cord injuries. The trial included 13 participants with neck-level injuries who were between …

This study compared two common nerve block techniques for pain relief after hip fracture surgery: femoral nerve block and suprainguinal fascia iliaca block. Only 17 adults participated before the trial was terminated early. The goal was to see which block reduces pain and the nee…

This study looked at whether a steroid (glucocorticoid) injection given around the time of surgery could improve wrist movement and reduce pain in adults with a broken wrist. About 38 people were planned to take part, but the study was stopped early. The goal was to see if the in…

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help children aged 8-15 with prolonged post-concussion syndrome after a mild brain injury. The trial planned to enroll 52 participants but was terminated early. The goal was…

This study looked at whether adding osteopathic manipulative treatment (OMT) — a hands-on therapy that moves muscles and joints — to standard care helps people recover from concussions. It included 39 people aged 13 to 55 who had a concussion within the last 12 days. The goal was…

This study tested whether personalized fitness training could improve heart and lung fitness in people with incomplete spinal cord injury during early rehabilitation. Nineteen participants were assigned to either personalized training sessions or usual care for six weeks. The stu…

This trial compared two ways of giving pelvic radiotherapy after surgery for endometrial cancer: standard 3D planning versus a newer technique called IMRT. The goal was to see if IMRT could reduce side effects like bladder and bowel problems. The study enrolled 92 participants bu…

This study looked at whether a special hand massage technique, called manual lymphatic drainage, could help clear fluid from the brain in people with moderate to severe traumatic brain injury. Only 2 people took part, and the study was stopped early. Researchers measured changes …

This study looked at whether weighted blankets can help reduce agitation and improve sleep in people recovering from a brain injury. Ten adults in a UK rehabilitation unit used the blankets for 7 days. The main goal was to see if such a study is practical in a hospital setting, n…

This study looked at two common ways to manage pain in children after elbow fracture surgery: opioids versus over-the-counter medications like ibuprofen and acetaminophen. The goal was to see if non-opioid options work just as well, reducing the need for opioid prescriptions. The…

This study tested whether 12 weeks of rowing exercise with electrical stimulation to move paralyzed legs could reduce nerve pain and brain inflammation in people with spinal cord injury. The study enrolled 13 adults with recent spinal cord injury. Researchers measured pain, brain…

This study tested a personalized walking and balance training program using a KineAssist robotic treadmill for people recovering from traumatic brain injury, stroke, or other acquired brain injuries. The goal was to safely challenge and improve walking speed, balance, strength, a…

This study looked at whether adding functional electrical stimulation (FES) to robotic hand therapy could improve arm movement in people who had a stroke within the past year. Researchers planned to compare two groups: one getting standard rehab plus robotic therapy and FES, and …

This small pilot study looked at whether adding functional electrical stimulation (FES) to reconstructive hand surgery can improve muscle strength and hand function in people with tetraplegia (paralysis of arms and legs). Fifteen adults with spinal cord injuries were enrolled. Th…

This study tested a device that sends electrical stimulation through the skin to the spinal cord, aiming to reduce muscle spasticity and improve movement in people with incomplete spinal cord injury. Twelve participants received repeated sessions of the stimulation. The goal was …

This study tested a new type of wound vacuum dressing on 7 people with chronic or acute wounds. The goal was to see if the dressing helps wounds heal or get better. The study was stopped early, so results are limited.

This study tested whether qigong, a practice of gentle movements and focused breathing, could reduce nerve pain in adults with spinal cord injury. About 23 people with chronic pain participated. The trial was stopped early, so the full effects are unclear.

This study tested whether nortriptyline, a common antidepressant, could ease headaches after a concussion better than a placebo. It included teens aged 13-21 with recent head trauma. The trial was stopped early after enrolling only 8 people, so the results are not reliable.

This small trial tested whether adding a special protein-and-vitamin powder to the diet could help older adults walk better after surgery for a broken femur. Only 20 people took part, and the study was stopped early. The main goal was to see if the supplement improved walking spe…

This study looks back at medical records of up to 118 patients in Italy who had surgery using the GALAXY FIXATION system or other Orthofix devices to stabilize fractures of the long bones (like the thigh or shin) or the pelvis. The goal is to see how well these devices hold the b…

This study tested a camera that detects natural glow (autofluorescence) from skin wounds and surrounding tissue. Researchers planned to catalog these glow patterns from 50 people with acute or chronic wounds, but the study was stopped early after only 11 participants. Because it …

This study compared two breathing techniques (CPAP and eSigh) in 18 patients with brain injury and acute respiratory distress syndrome (ARDS). The goal was to see which method better maintains oxygen levels in the brain without causing harm. The trial was terminated early, so fin…

This study tested three portable inhaler devices in 10 healthy adults to see how accurately they measure airflow and record breaths. No medication was used—only a harmless salt solution. The goal was to compare device performance and user comfort, not to treat any disease.

This study aimed to find out whether performing surgery within 48 hours of a severe burn (early excision) or later improves survival. It planned to follow 470 severely burned adults, but was terminated early and did not complete enrollment. Because of this, the results are limite…

This study looked at the VERTICALE Cervical System, a device used to stabilize the spine during surgery. Researchers planned to track neck disability in patients with conditions like degenerative disc disease or trauma. Only 4 patients were enrolled before the study was terminate…

This study tested a new technique that uses a special form of creatine (deuterated creatine) to measure muscle mass more directly and accurately in older adults. The goal was to see if this method works well in both healthy older adults and those recovering from a hip fracture. T…

This study looked at how a person's sense of smell changes after endoscopic endonasal skull base surgery, a procedure done through the nose to remove tumors or other abnormalities. Researchers measured smell using a simple identification test in 50 patients before and after surge…

This study looked at how breathing pure oxygen in a high-pressure chamber (hyperbaric oxygen therapy) changes the body's automatic heart control in people with neurological injury. Researchers planned to measure heart rate variability in 17 patients before and after treatment. Th…

This study looked at whether washing out the ankle joint with salt water within 48 hours of a fracture can lower inflammation and prevent cartilage breakdown. Researchers measured chemicals in the joint fluid of 41 adults before and after surgery. The goal was to see if early cle…

This study looked at the safety and performance of the Fitbone Transport and Lengthening Nail, a device implanted in the bone to help repair large bone gaps or correct leg length differences. Only one person took part before the study was stopped early, so the results are very li…

This study looked at whether dissolvable stitches (chromic gut) or non-dissolvable stitches (nylon) work better for hand and forearm cuts treated in the emergency room. Six adults with such cuts were followed for 12 weeks to compare scar healing and pain. The goal was to see whic…

This study aimed to understand how and when injuries happen during CrossFit training. Over 500 participants from Reunion Island filled out questionnaires about their injuries for up to 12 months. The goal was to identify injury locations, causes, and patterns to help make the spo…

This study aimed to collect movement data from healthy teens aged 13-25 who play land-based sports. Researchers wanted to create a baseline of normal movement patterns to compare with injured athletes. The study was terminated early and enrolled only 14 of the planned 40 particip…

This early-phase study tested whether breathing mild low-oxygen air (acute intermittent hypoxia) combined with hand exercise training could improve grip and pinch strength in people with chronic cervical spinal cord injury. The study also tested the drug D-cycloserine to see if i…

This study tested a drug called Oxycyte in people with severe head injuries to see if it could safely increase oxygen levels in the brain. Only 9 patients took part before the study was stopped early. The main goal was to measure how the drug affected brain chemistry, but no clea…

This study aimed to create and test an educational resource for children with mild traumatic brain injury (concussion) and their parents. Researchers planned to work with stakeholders like doctors, coaches, and school nurses to develop the resource and see if it could be used in …

This study aimed to see if a cast that keeps the elbow straight or bent works better for certain forearm fractures in children. Only 3 children joined before the study was stopped early. Because of this, we cannot say which cast is better.

This study looked at how blood clotting and inflammation change over time in adults with serious burns. Researchers examined tiny particles released by cells into the blood, which may play a role in infections and inflammation. The goal was to learn how to reduce bleeding, transf…

This study looked at whether a special exam called Mechanical Diagnosis and Therapy (MDT) could help classify people with concussions based on how they respond to certain movements. Researchers planned to enroll people aged 13 to 65 with neck pain, headache, or dizziness after a …

This study tested whether a non-invasive electrical stimulation applied to the skin over the upper spine could temporarily improve arm and hand strength, control, and spasticity in people with traumatic brain injury. Only 14 participants were enrolled before the study was termina…

This study tested new GentleFit non-invasive ventilation masks and prongs in children up to 3 years old. Researchers compared how well these interfaces delivered air pressure and monitored skin health over 24 hours. The goal was to see if the new designs fit better and work as we…

This study followed 10 people who received an ESOP 2 hip stem during total hip replacement. Researchers wanted to see how safe and effective the device was over 10 years in real-life use. The study was stopped early, so the full long-term picture is incomplete.

This study looked at whether a non-invasive magnetic brain stimulation technique called iTMS, combined with hand exercises, could help people with spinal cord injury regain grasping ability. Researchers measured changes in brain signals and hand strength. The trial was terminated…

This study tested a group wellness program for women living in an emergency shelter after experiencing intimate partner violence. The program included mindfulness and health activities to improve physical and emotional well-being. Only 10 women took part, and the study was stoppe…

This study looked at a specific hip implant shell (the Pinnacle Acetabular Shell) used in total hip replacement. Researchers wanted to see how much the implant moved (migrated) over two years using a special X-ray technique called RSA. They also tracked how patients felt and func…

This study aimed to compare two ways of setting breathing machine pressure (PEEP) in patients with severe lung injury (ARDS). The goal was to see which method better protects the lungs and heart. Only 2 patients were enrolled before the study was stopped, so no meaningful results…

This study tested a new questionnaire called the Brain Injury Self-Efficacy Scale to see how well it measures a person's confidence in managing challenges after a brain injury. Researchers compared it with other standard self-efficacy scales. The study involved 150 adults with a …

This pilot study aimed to see if antiseizure drugs like phenobarbital and levetiracetam change brain connectivity patterns in people with severe acute brain injury and reduced consciousness. Only 5 participants were enrolled before the study was terminated. Researchers used resti…

This study looked at whether measuring two proteins in the blood (S100B and copeptin) can help doctors decide if a child with a head injury needs a CT scan. Many children get CT scans that are normal, exposing them to radiation. The study enrolled 167 children aged 3 months to 15…

This study aimed to compare two common sedatives, propofol and midazolam, in patients with traumatic brain injury who needed a breathing tube. Researchers wanted to see if one drug led to better recovery or different levels of inflammation markers called cytokines. However, the t…

This study aimed to collect eye scans from people who had COVID-19 to see if the virus caused damage to the retina, the light-sensitive tissue at the back of the eye. Researchers planned to compare severe and mild COVID-19 cases, but the study was stopped early and only enrolled …