Injury

This trial compares three sedatives—propofol, midazolam, and dexmedetomidine—for controlling pressure inside the skull after urgent brain surgery for moderate-to-severe traumatic brain injury. Adults who have had surgery within 24 hours of injury will receive one of the three dru…

This study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…

This trial tests a culturally adapted program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) for trauma patients who drink alcohol. Emergency department staff in Cameroon will screen patients for risky drinking, offer a short motivational counseling sessi…

This study compares two ways of using breathing machines in adults with severe burns (covering 20% or more of the body). One method, called Adaptive Support Ventilation (ASV), automatically adjusts the machine's settings to the patient's needs. The other is standard lung-protecti…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests whether stem cells taken from a patient's own belly fat can improve bone healing after surgery for a broken jaw. Twenty adults with jaw fractures will either get standard surgery plus stem cells or standard surgery alone. Researchers will check bone density and c…

This study will test a new powered prosthetic hand system called Point Powered in 10 adults who have lost part of their hand. The device uses muscle signals to control moving fingers. Researchers will compare it to each person's current prosthetic to see if it improves hand funct…

This study will follow 40 people who receive a shoulder replacement using the HUMELOCK II stem, either for a broken shoulder or to replace an old implant. Researchers will track how long the implant lasts, how well the shoulder moves, and any problems over 10 years. The goal is t…

This trial investigates whether applying vancomycin powder directly to open fracture wounds in the emergency department can reduce deep infections. Adults with open fractures are randomly assigned to receive either standard care or standard care plus a single dose of vancomycin p…

This study tests whether a new shelf-stable blood product (IFC) works faster than the standard cryoprecipitate to stop severe bleeding in trauma patients. About 320 adults with traumatic injuries and low fibrinogen levels will be enrolled. The goal is to see if IFC can be given m…

This study tests a less invasive surgical approach for severe thoracolumbar burst fractures, a type of spinal injury. The procedure combines vertebral augmentation (using a device to restore bone height) with percutaneous fixation (screws placed through small incisions). The goal…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study compares two common surgeries for broken hand bones: placing a small screw inside the bone versus using pins and a cast. About 100 adults with hand fractures will be randomly assigned to one of these treatments. The goal is to see which method helps people regain movem…

This study compares robot-assisted surgery to conventional surgery for treating unstable pelvic fractures (Tile B and C types). About 88 adults with recent fractures will be randomly assigned to one of the two procedures. Researchers will measure pain, function, recovery speed, a…

This early-phase study tests whether a special dye (methylene blue) activated by blue light can safely reduce bacteria in burn wounds. About 50 adults with partial- or full-thickness burns will receive either the light treatment or light alone during two dressing changes. The goa…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study compares two methods of preserving livers from deceased donors before transplant: a machine that pumps oxygenated cold fluid through the liver (hypothermic machine perfusion) versus the standard ice-cooled storage. Forty adult liver transplant patients will be randomly…

This early-stage trial tests whether transplanting a patient's own nose cells into the spinal cord, combined with intensive exercise, is safe and possible for people with chronic spinal cord injury. About 30 participants will receive the cell transplant and a 32-week rehab progra…

This study tests whether adding Platelet-Rich Fibrin (PRF) – a natural substance made from your own blood – to a bone graft helps the extraction site heal faster and grow more bone. Fourteen adults needing two tooth extractions will receive PRF plus bone graft in one socket and s…

This study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs an…

This study looks at how to best give muscle relaxants to patients with severe lung failure (ARDS) who are on a breathing machine. It compares giving the drug as a steady drip versus as separate shots. The goal is to see which method is safer and works better, and to plan a larger…

This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 p…

This trial tests a new type of nail made from magnesium and titanium to fix broken leg or arm bones. The nail is designed to provide strong support while part of it gradually dissolves over time. Researchers will compare it to standard metal nails in 160 adults to see if it is ju…

This study tests a blood-filtering device called Efferon LPS in 50 people with severe burns. The goal is to see if it can reduce dangerous inflammation and prevent organ failure. Participants will either receive standard care or standard care plus the blood filter. The study focu…

This early study tests whether a hormone called hCG (Ovidrel) can help men recover thinking and daily living skills after a moderate to severe traumatic brain injury. Fifty men will receive either the hormone or a placebo twice a week for 24 weeks. The main goal is to check safet…

This study tests whether giving plasma (a part of blood) as soon as possible to adults with severe burns over at least 20% of their body can lower the chance of death or organ failure. About 750 patients will be randomly assigned to receive either early plasma or standard fluids.…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This early study is testing a new dressing made from sodium hyaluronate and carbomer hydrogel for first and shallow second-degree burns. The goal is to see if it helps the burn heal completely within 50 days and reduces itching. The study will involve 30 adults with burn wounds o…

This study compares two ways to treat a common elbow fracture in children (Gartland type II). Half the children will get a cast after the bone is set, and the other half will have surgery with pins. Researchers will measure how well the arm works, how much it can move, and pain l…

This early-stage study tests the safety of a drug called pegcetacoplan (Empaveli) in 20 adults who have had a stroke from a large clot and already had a procedure to remove it. The drug aims to reduce swelling and inflammation that can occur when blood flow returns. Participants …

This study looks at whether applying a patient's own skin cells (called a basal cell suspension) to surgical wounds can help them heal faster and with less scarring. Researchers will compare 500 people who get this extra treatment with 500 who get standard surgery alone. The goal…

This study tests a brain-computer interface (BCI) implant in 10 people with tetraplegia (paralysis of all four limbs) from brainstem or spinal cord injury. The implant reads brain signals to control a pneumatic hand glove, helping patients grasp objects like cups or phones. The t…

This study looks at whether spraying a patient's own skin cells onto second-degree burns, followed by a biological dressing, helps wounds heal faster and with less scarring. About 386 people will take part across multiple hospitals in China. Researchers will compare those getting…

This study is testing whether adding a cold atmospheric plasma device to standard wound care helps different types of wounds heal better. The device uses low-temperature plasma to kill bacteria and promote healing. Researchers will compare 500 patients who get plasma therapy plus…

This early study tests a special cap that shines near-infrared light on the heads of infants who have had a cardiac arrest in the hospital. The light is meant to reduce brain injury caused when blood flow returns. The trial will include 30 infants with heart disease and will chec…

This study tests if a new surgical method—gently stretching the bone under the wound and then placing a skin graft—can help diabetic foot ulcers heal better than skin grafts alone. About 104 adults with hard-to-heal foot sores will be randomly assigned to get either the combined …

This study will follow 120 adults aged 60 and older who have a pelvic fracture and are scheduled to receive the iFuse TORQ TNT implant, a screw-like device that stabilizes the pelvis. Researchers will check if the device stays in place, doesn't break, and doesn't require addition…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study will test a new medical device kit (Novalung ultimate kit with Xenios 2.0) in 20 adult patients with severe heart-lung failure who need ECMO life support. The goal is to see if the device safely and effectively maintains blood oxygen levels during hospital use and grou…

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This pilot study will compare two types of pedicle screws (monoaxial vs. polyaxial) used with cement and balloon kyphoplasty to treat spine fractures in people aged 60 and older. The goal is to see which screw type better corrects spine curvature and improves recovery. Forty-four…

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

This study looks at three ways to treat a specific type of shoulder fracture (greater tuberosity fracture) that also involves a rotator cuff injury. The three options are: non-surgical care, surgery right away, or surgery after a delay. The goal is to see which approach leads to …

This study looks at two different surgical methods for repairing a broken hip (hemiarthroplasty) in 100 adults. The goal is to see if one approach leads to better function and fewer complications after surgery. Participants will be randomly assigned to one of the two methods and …

This study tests whether giving the numbing drug lidocaine during heart surgery can reduce lung damage in infants. 320 babies under 1 year old having heart surgery will receive either lidocaine or a placebo. The goal is to see if lidocaine lowers the severity of lung injury after…

This early-stage trial tests a lab-grown penile tissue made from a man's own cells to repair severe, irreversible damage to the penis. Ten men aged 18-60 who have failed standard treatments will receive the implant. The main goal is to check safety, not effectiveness.

This study tests whether a special placental tissue dressing (AmCoreMatrix Burn) helps second-degree burns heal faster than standard care. About 70 adults with burns covering 5-15% of their body will take part. The main goal is to see how quickly the burn skin fully closes.

This study tests whether a drug called istradefylline can boost the walking improvements seen with low-oxygen therapy in people with chronic, incomplete spinal cord injury. About 40 adults aged 18-75 with injuries at least one year old will receive the drug or a placebo before wa…

This study tests whether giving growth hormone to elderly patients (60+) with moderate to severe brain injury and low blood protein can improve their nutritional status. Half of the 160 participants will get daily growth hormone shots plus standard care, while the other half gets…

This study tests whether custom-made 3D plates are better than standard titanium plates for fixing a specific type of jaw fracture (sub-condylar fracture). About 30 adults aged 18-60 with recent, displaced fractures will be randomly assigned to receive either a custom plate or a …

This study is testing a new dressing called ConvaNiox that releases nitric oxide to help heal diabetic foot ulcers. About 102 adults with diabetes and a foot ulcer will receive the dressing along with standard care. Researchers will measure how much the wound shrinks over time an…

This study looks at whether using an automatic lung re-expansion feature on anesthesia machines can improve lung function and reduce complications in elderly patients (65+) after laparoscopic surgery. About 58 participants will be randomly assigned to receive either the automated…

This study tests a surgical technique to cover deep wounds on the lower leg, ankle, heel, or foot. The procedure moves skin and tissue from the outer lower leg to the wound area, using a special blood supply to help it heal. The study will include 30 adults and will measure how w…

This study tests a robot-assisted, gamified rehabilitation program for children aged 7-16 with acquired brain injury. The program combines 15 supervised hospital sessions with 15 home-based sessions on a tablet, guided by an interactive avatar. Researchers will measure improvemen…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This study tests a special bone glue that dissolves over time, used alongside metal plates and screws to fix a broken wrist. About 20 adults with a specific type of wrist fracture will receive the glue during standard surgery. Researchers will check if the glue is safe and helps …

This study tests whether an interactive virtual reality (VR) system, where patients move to play games, can improve arm and leg function better than just watching VR. Sixty adults recovering from a stroke or traumatic brain injury will use the VR system three times a week for eig…

This study tests whether combining spinal cord stimulation with physical therapy can improve arm and hand movement in people with cervical spinal cord injury. Forty participants will receive either real stimulation or a sham version during 20 therapy sessions over 6-8 weeks. Rese…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This study will test whether combining exoskeleton-assisted walking with a mild electrical stimulation to the spinal cord can improve muscle size and bone strength in people with chronic spinal cord injury. Twenty-four participants who have been injured for more than three years …

This study tests whether the drug epoprostenol, given alongside standard care, can reduce the need for amputation in people with severe frostbite. About 66 adults with grade 2-4 frostbite will receive either the drug or a placebo within 72 hours after rewarming. The goal is to se…

This early-phase trial tests whether adding hydrogen gas to standard cooling therapy is safe and feasible for newborns who suffered brain injury from lack of oxygen at birth (HIE). About 54 infants will be randomly assigned to receive either standard cooling alone or cooling plus…

This study will test a new, personalized smart home care model for older adults (60+) recovering from a hip fracture. The goal is to predict and improve recovery, reduce falls, and support caregivers. About 218 people from northern Taiwan will take part.

This study tests whether combining spinal cord stimulation with physical therapy can help people with non-traumatic spinal cord injury regain leg movement and the ability to stand or step. Ten adults who have had a spinal cord injury for at least one year and cannot walk independ…

This trial is testing whether giving a special type of radiation (ultra-hypofractionated) along with immunotherapy before surgery is safe and feasible for people with retroperitoneal sarcoma. The study will enroll 28 participants. The main goal is to see how many patients have co…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests whether a home-based telerehabilitation program using a virtual reality device can help people recover motor and cognitive skills after a severe acquired brain injury as effectively as in-person therapy. Sixty-two adults aged 18 to 75 with brain injury will be as…

This early-stage trial tests whether a single dose of CRIS100 is safe for people with a recent spinal cord injury in the upper back. Only 5 adults with severe injuries will receive the drug directly at the injury site within 72 hours. The study focuses on side effects and lab cha…

This study looks at a new surgical technique to repair deep cuts in finger tendons without using a splint afterward. Forty adults will have the surgery and start moving their fingers gently right away. The goal is to see if this approach leads to better hand movement and strength…

This study tests whether a device that gently stimulates a nerve in the ear can reduce brain damage and inflammation after a traumatic brain injury or bleeding stroke. Sixty adults will be randomly assigned to receive either real stimulation or a sham (fake) treatment. Researcher…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study tests whether a sodium lactate infusion is safe for people with severe traumatic brain injury in the ICU. Researchers will monitor side effects and survival in 264 adults. The goal is to see if this approach is safe enough to study further.

This study tests whether walking in a robotic exoskeleton combined with mild electrical stimulation of the spinal cord can improve muscle and bone health in people with chronic spinal cord injury. About 24 participants will be assigned to either active or sham stimulation during …

This study tests whether setting a personalized 'optimal' blood pressure for each patient with severe traumatic brain injury reduces brain damage compared to standard fixed targets. Researchers will enroll 60 adults in the ICU and measure brain injury markers in the blood over fi…

This study will compare aspirin tablets to daily injections of low molecular weight heparin (LMWH) for preventing dangerous blood clots in people who break their hip. Over 21,000 patients aged 60 and older across 96 UK hospitals will take part. Hospitals will switch between the t…

This study tests whether a personalized ventilation strategy guided by electrical impedance tomography (EIT) can improve survival in adults with acute respiratory distress syndrome (ARDS). About 574 participants will be randomly assigned to receive either EIT-guided ventilation (…

This study tests whether a computer program called Burn Navigator™ can better guide fluid replacement in adults with severe burns (covering at least 20% of the body) compared to the standard Parkland formula. The software uses real-time patient data to recommend hourly fluid amou…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study looks at whether using both a nail and a plate together can better fix certain complex hip fractures. The approach is meant to prevent the bone from collapsing and help people heal faster. Seventeen adults with these fractures will be followed for six months to check b…

This study compares two ways to treat a Colles' fracture (a broken wrist). One group gets a plaster cast after the bone is set; the other gets a small metal pin (K-wire) plus a cast. Researchers will check wrist function in 60 adults aged 18–60 to see which method works better.

This study tests whether tranexamic acid (TXA), a drug that helps stop bleeding, can improve recovery in 2000 severely injured children with brain or torso injuries. The goal is to see if TXA reduces bleeding and improves quality of life and thinking skills. The trial is for chil…

This study will compare two surgical techniques for fixing specific types of fractures in the roof of the mouth (palate). Forty patients will be randomly assigned to receive either a miniplate or a wire stabilization procedure. The main goals are to see which method better restor…

This study tests whether metformin, a common diabetes medicine, can help people recover after a spinal cord injury. The drug may reduce scar tissue that blocks nerve healing. Researchers will give metformin or a placebo to 34 adults with recent thoraco-lumbar spinal cord injury a…

This study tests whether a special arm-crank exercise (eccentric training) can improve upper body strength and daily function better than standard strength training for people recovering from a spinal cord injury. Twenty participants will do 20 sessions of one type of training ov…

This study tests whether giving magnesium sulfate early through an IV can reduce dangerous narrowing of brain arteries after a traumatic brain bleed. About 50 adults with head injuries will receive the treatment within 24 hours. The goal is to see if it lowers the risk of delayed…

This early-phase study tests whether a concentrated form of the patient's own growth factors can improve motor function after a spinal cord injury. Ten adults with moderate to severe traumatic spinal cord injury will receive the treatment. The goal is to see if this approach can …

This study tests a new stem cell therapy called XS228 for people with recent spinal cord injuries. The treatment uses lab-made nerve cells injected into the spinal fluid to help repair damage. About 60 adults with incomplete paralysis will receive either XS228 or a placebo and be…

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This pilot study tests whether a combination of two blood thinners (rivaroxaban and aspirin) can prevent heart attacks and blood clots in patients who had a hip fracture surgery and also suffered a heart injury. About 100 adults aged 45 and older will be randomly assigned to eith…

This study follows 16 people who already received EG110A, a gene therapy that uses a modified herpes virus to deliver a botulinum toxin-like protein to relax bladder muscles. Researchers will track side effects and how well the treatment works over five years. The goal is to see …

This study tests whether adding a patient's own fat tissue under a standard skin graft can improve healing and reduce scarring after severe burns or traumatic wounds. About 68 adults with deep skin loss will receive either the new fat-plus-skin graft or a traditional skin graft a…

This study tests whether using a person's own fat, combined with a skin graft, can improve tight scars from burns or injury better than standard skin grafting alone. Forty adults with scar contracture will receive either the new fat-plus-skin method or the usual full-thickness sk…

This Phase 3 trial will test whether a graft made from donated amniotic tissue can help heal chronic wounds like diabetic foot ulcers and venous leg ulcers better than standard care. About 600 adults with wounds that haven't healed in 4 weeks will take part. The study will measur…

This phase 4 trial will test whether tranexamic acid (TXA), a drug that reduces bleeding, can safely lower blood loss in 200 orthopedic trauma patients who are on anticoagulants (blood thinners). Participants will have surgery for broken leg or thigh bones. The study compares tho…

This study tests whether a single dose of valproic acid, given soon after a moderate to severe traumatic brain injury, can improve patients' recovery and reduce disability. About 432 adults aged 18 to 65 will be randomly assigned to receive either valproic acid (at a low or high …

This study compares three common surgical techniques for fixing simple hand fractures: a screw, a plate, or pins. About 111 adults with fractures in the long fingers (excluding the thumb) will be randomly assigned to one method. The goal is to see which approach gives the best ha…

This early-phase trial tests whether umbilical cord blood cells can safely help people with chronic radiation enteritis, a painful gut condition caused by cancer radiation therapy. Ten adults who have had pelvic or abdominal radiation will receive three weekly infusions of these …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This study tests an AI-powered imaging device called DeepView to see if it can accurately assess burn injuries on the hands, head, and feet. Researchers will collect images from people with burns in these areas to train and improve the AI system. The goal is to help doctors make …

This study will test a device called Delphi-MD that uses magnetic pulses and brain wave recordings to diagnose traumatic brain injury (TBI). Researchers will compare results from 215 people with TBI to healthy controls, looking for patterns that could help identify and assess bra…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study will test a blood test called the Abbott i-STAT™ TBI Plasma Test in 200 adults who come to the emergency room with a traumatic brain injury. The test looks for two brain proteins (GFAP and UCH-L1) in the blood. Researchers will compare the blood test results to CT scan…

This study looks at whether adding an ultrasound to a CT scan can find more rib cartilage fractures than a CT scan alone. Researchers will follow 100 adults with chest injuries to see if finding these hidden fractures changes treatment, such as whether surgery is needed. Particip…

This study tests whether an AI software called RBfracture helps clinicians better identify fractures, dislocations, and joint fluid buildup on X-rays. Sixteen doctors will review X-rays from 415 adult patients with and without the AI's help. The goal is to see if the AI improves …

This study looks at whether advanced heart tests and blood markers can find early signs of heart damage in children who had chemotherapy or chest radiation for cancer. About 100 survivors aged 2 to 25 will undergo special echocardiograms, exercise tests, and wear activity monitor…

This study tests a blue dye called Bludigo® to help surgeons see if the tubes from the kidneys to the bladder (ureters) are open during surgery in children. About 18 children under 17 will get the dye through an IV, and surgeons will watch for blue urine to confirm the ureters ar…

This study tests a portable device that uses near-infrared light to find brain bleeds in people with traumatic brain injury. The goal is to see if it works as well as a CT scan, especially in places like battlefields or rural areas where CT machines aren't available. About 80 adu…

This study will check if a non-invasive device can accurately detect high pressure inside the skull in 300 adults with traumatic brain injury or stroke. The device uses a sensor placed on the head to measure brain pressure and pulse waves. If successful, it could help doctors mak…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This study tests whether repositioning a breathing tube every 4 hours versus every 8 hours can prevent mouth injuries in ICU patients. 230 adults on ventilators will be randomly assigned to one of the two schedules and monitored for 14 days. The goal is to find a clear time guide…

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests a safety bundle—staff training, checklists, and audits—to prevent surgical site infections after emergency C-sections and open leg fracture repairs in Ethiopia. About 1,000 patients at public hospitals will be followed for 2 years to measure infection rates and d…

This study tests a one-year lifestyle program designed to help people with traumatic brain injury lose weight and prevent diabetes. The program includes 22 sessions over a year, focusing on healthy eating and physical activity. Researchers will track weight, blood pressure, and b…

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study tests whether a higher dose of the blood thinner enoxaparin can better prevent dangerous blood clots in the legs or lungs of severely injured patients. About 540 adults in intensive care after trauma will receive either the standard or a double dose. The goal is to see…

This study tests whether removing a thin layer of tissue (pseudomembrane) from the back of the nose using a scope can prevent radiation-induced tissue death in patients with recurrent nasopharyngeal cancer who have had repeat radiation. About 40 adults in China will undergo the p…

This study tests whether a modified herbal mouthwash can prevent painful mouth sores caused by radiation therapy in people with head and neck cancer. About 156 participants will use either the herbal mouthwash or a placebo during their radiation treatment. The goal is to see if t…

This phase 2 trial tests whether a nitric oxide spray (glyceryl trinitrate) can prevent dangerous blood pressure spikes during bowel care in people with spinal cord injury. 26 participants will receive either the active spray or a placebo during two at-home bowel care sessions. T…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether giving anti-epileptic drugs right after a traumatic brain injury can prevent seizures. About 70 adults with moderate to severe head injuries will receive either the drug or standard care. Researchers will track seizure episodes and recovery over 3 months …

This study tests a program where nurses talk to parents of hospitalized children about safely storing firearms and offer free cable locks. The goal is to see if this brief conversation changes how parents store guns at home, potentially preventing accidental shootings and suicide…

This study will test whether an 8-week personalized exercise program can reduce injury risk in 100 university basketball and volleyball players. Athletes who score below certain thresholds on balance, strength, and flexibility tests will receive tailored exercises. Researchers wi…

This study tests whether a simple pre-game safety huddle—where coaches, referees, and players briefly talk about the importance of reporting concussion symptoms—can improve concussion reporting in youth soccer. Researchers will enroll 2,000 children aged 9-13 and their coaches ac…

This study looks at whether a single dose of the antibiotic ceftriaxone can prevent early pneumonia in 60 brain-injured patients who need a breathing tube. Researchers will measure drug levels in the blood to see if enough reaches the infection site, especially in patients with f…

This study tests whether combining square stepping exercises with BOSU ball training can improve balance and strength in badminton players. Sixty-six players with at least one year of experience will do these exercises for 8 weeks. The goal is to see if this combo helps prevent c…

This study tests whether a steroid nasal spray can prevent fluid buildup in the middle ear, a common side effect of radiation therapy for nasopharyngeal cancer. About 168 adults who are about to start radiation will use either the spray or a placebo for 12 months. The goal is to …

This study tests whether adding a medication called 5-fluorouracil to a standard steroid treatment helps improve thick, raised burn scars more than the steroid alone. Both treatments are delivered through tiny holes made by a CO2 laser, which helps the medications reach deeper in…

This study tests whether using ozonated soap and oil after open abdominal surgery leads to better scar quality than standard care alone. About 144 adults having scheduled abdominal surgery will be randomly assigned to either add the ozonated products to their usual wound care or …

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This trial tests whether adding a specific nerve block (Quadro-Iliac Plane Block or Suprainguinal Fascia Iliaca Block) to standard pain management reduces the need for opioids after hip fracture surgery. About 90 adults having hip fracture surgery under spinal anesthesia will be …

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into an episiotomy cut right after childbirth can improve healing and reduce pain. Two hundred women will be randomly assigned to receive either PRP or standard wound care. Researchers will check wound he…

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This study tests two ways to numb the arm for wrist fracture surgery in people at high risk for severe pain. One method uses a long-acting numbing drug (liposomal bupivacaine) plus regular bupivacaine, and the other uses a steroid (dexamethasone) plus regular bupivacaine. The goa…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study tests whether giving iron supplements to older adults (75+) after hip fracture surgery can reduce fatigue and improve recovery. 528 participants will receive either intravenous iron, oral iron pills, or a placebo. The goal is to see if iron helps with energy, mobility,…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study compares two surgical methods for fixing a broken shinbone (tibia). One technique enters above the kneecap, the other from the side of the kneecap. Researchers will measure knee function, pain, and recovery in 40 adults aged 18-60. The goal is to find which approach le…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether a single injection of a slow-release painkiller (liposomal bupivacaine) into a nerve block can control pain for up to 72 hours after hip fracture surgery in older adults. The standard drug only lasts about 12 hours, often leading to more pain and opioid u…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study will test a special hydrogel patch containing dexpanthenol (a form of vitamin B5) on small, controlled scrapes in 40 healthy adults. Each person will have two identical scrapes on their forearms: one treated with the new patch and the other with a standard plaster. Res…

This study tests whether spending time in nature can help people recover faster from a concussion. 24 participants aged 14-35 who recently had a concussion will either do guided awareness exercises in a natural setting or indoors. Researchers will track symptoms, thinking speed, …

This study tests whether wearing a special cast for one week can improve thick, itchy burn scars. Researchers will compare treated scars to untreated ones in 38 adult burn survivors. They will measure changes in scar thickness, redness, moisture, itching, and pain.

This study tests two intravenous medications—metoclopramide and acetaminophen—to see which one better relieves acute concussion symptoms like headache, dizziness, and nausea in emergency room patients. Researchers will enroll 200 adults with mild head injuries and track their sym…

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study tests a 12-week program where a person with traumatic brain injury and a close supporter work with a therapist to improve communication and emotional support. The goal is to reduce isolation and improve health. The study involves 60 participants and focuses on whether …

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This study tests whether Frenkel exercises—slow, controlled movements to improve coordination—can help people with lower limb burns regain balance and improve their quality of life. Seventy adults aged 25 to 45 with second-degree thermal burns on their legs will be split into two…

This early-stage study tests a gel called LUT017 on small skin wounds from mole removals in healthy adults. Each person gets the gel on one wound and a placebo on another to compare healing. The goal is to see if the gel is safe and might help wounds close faster. Only 9 people w…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study tests whether a safe, noninvasive brain stimulation technique called tDCS, combined with thinking exercises, can improve attention, memory, and problem-solving in people who had a traumatic brain injury at least two years ago. About 20 adults will receive personalized …

This study tests if using a floor pedal bike at home helps people recover from leg fractures and ankle injuries. Twenty adults with these injuries will get a bike at their first post-surgery visit and be asked to use it regularly. Researchers will track their physical activity an…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This study compares two different skin incisions used during surgery to repair a cut tendon in the finger. Seventy patients will be randomly assigned to receive either a standard zig-zag cut or a modified side zig-zag cut. Researchers will measure pain, swelling, and finger movem…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This study tests a 14-day home program called BraW-Day™ that combines brain exercises (like counting backwards) with walking, delivered via a smartphone app. Researchers want to see if doing both tasks together improves thinking, balance, and mood in athletes aged 18-40 who had a…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study tests whether using a fractionated CO₂ laser on wound edges during Mohs skin cancer surgery can improve scar appearance. Fifty adults having Mohs surgery will have half their wound treated with the laser and the other half left untreated. Researchers will compare scar …

This study will test whether a daily aromatherapy massage, combined with a sensory stimulation program, can improve cognitive function in intensive care patients with brain injuries. Sixty adults on ventilators or oxygen will be randomly assigned to receive the treatment from a f…

This study tests whether playing virtual reality games like Beat Saber can improve memory, attention, and thinking speed in people with acquired brain injury. Fifteen participants will do 15 sessions of VR training over 5 weeks, plus their usual rehab. The goal is to see if this …

This study tests whether adding emotional and social support to standard medical care helps people recover from moderate to severe orthopedic injuries. It involves 804 patients, their care partners, and healthcare workers across multiple hospitals. The goal is to reduce anxiety a…

This study tests whether a special yoga program designed for trauma survivors can reduce trauma symptoms, improve emotion control, and increase body awareness in young women aged 18-25. About 46 women with high trauma scores will be randomly assigned to either the yoga group or a…

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests a stepped-care version of Parent-Child Interaction Therapy (PCIT) for children aged 2 to 7 who have a mild to moderate traumatic brain injury and behavior problems. The program teaches parents positive parenting skills through online modules and weekly therapist …

This study tests whether a device called TENS, which sends mild electrical pulses through the skin, can reduce pain and the need for painkillers in older adults with hip fractures. Thirty-two participants will receive either active TENS or a sham (fake) version for 45 minutes. Re…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study compares four types of stitches used after minor oral surgery to see which ones cause the least pain and discomfort. Sixty adults will receive all four suture materials in different parts of their upper jaw and report their experiences over two weeks. The goal is to he…

This study tests whether placing a thin layer of the patient's own fat under a skin graft on the penis leads to better healing, feel, and function. Twenty-four men scheduled for reconstructive penile surgery will be randomly assigned to receive either the standard skin graft alon…

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This study looks at whether inhaling a bronchodilator (salbutamol) at a different lung volume helps it work better in people with COPD. 30 participants will inhale the medication either from a low lung volume (as usually done) or from a higher, more relaxed volume. The goal is to…

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study tests a single 90-minute therapy session for teens aged 13-18 who have experienced trauma and are waiting for longer treatment. The session teaches coping skills and understanding of trauma cues. About 40 teens in New Zealand will take part to see if this approach is p…

This study tests a new ankle orthosis (brace) in 4 people with chronic ankle injuries or nerve damage that limits ankle movement. Participants will wear the new brace for one month and compare it to their usual brace or no brace. The goal is to see if the new device improves ankl…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study will see if adding a cold plasma device to standard scar care helps improve scars like keloids, burn scars, and acne scars. About 800 people will take part, with half getting standard care plus plasma and half standard care alone. Researchers will track changes in scar…

This study tests a new treatment for burn scars on the chest, shoulders, and back. Doctors will take a small amount of fat from the patient's belly or thigh, process it into a liquid rich in healing cells, and inject it into the scar. The goal is to improve the scar's look, feel,…

This study tests whether giving lidocaine through an IV during surgery can lower the amount of opioids needed for pain in children aged 3-18 having arm fracture repair. Half the children will get lidocaine, half a placebo, and researchers will compare opioid use and pain scores. …

This study tests a 12-session group program called ENGAGE-TBI for adults who had a traumatic brain injury (TBI) at least 6 months ago. The program, led by an occupational therapist and a TBI survivor, focuses on social skills and problem-solving. Researchers want to see if it's p…

This study tests whether special dissolving nails can heal children's broken forearm bones as well as standard titanium nails. The dissolving nails go away on their own, so many kids might not need a second operation to remove them. About 60 children who need surgery for a displa…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study looks at whether a nerve block called a serratus plane block can help people with multiple broken ribs breathe better and feel less pain. 72 adults with at least two broken ribs on one side will be split into three groups: standard painkillers alone, standard painkille…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study compares three different wrist positions (bent back, straight, or bent forward) in a 3D-printed hand splint used after flexor tendon repair. About 64 people who had surgery on finger tendons will be randomly assigned to one of three splint positions and follow the same…

This study tests whether using a virtual reality headset or a smartphone during burn dressing changes can lower pain and anxiety. 99 adults with second-degree burns will be randomly assigned to VR, smartphone, or standard care. Pain and anxiety are measured right after the dressi…

This study looks at whether surgically repairing a nail bed injury leads to better nail appearance and less pain compared to just cleaning and bandaging the injury. About 100 people with nail injuries will be randomly assigned to one of the two treatments. The goal is to find out…

This study tests a patient empowerment program for veterans with spinal cord injury and neurogenic bladder who have had at least one urinary tract infection in the past year. The program provides training and tools to help them recognize when antibiotics are not needed and advoca…

This study tests whether an AI-based smartphone app can improve recovery for 106 adults after hip or knee replacement or hip fracture surgery. Participants use the app for 12 weeks at home to get real-time feedback on their exercises, while a comparison group follows the same exe…

This early study tests whether applying nitroglycerin ointment (a medicine that widens blood vessels) to surgical wounds during high-risk leg surgeries can improve blood flow and reduce complications like infection or wound separation. Fifteen adults undergoing specific ankle, he…

This early-phase study tests whether applying cannabidiol (CBD) with silicone ointment helps scars heal better after paramedian forehead flap surgery. Twenty-two adults will have half their scar treated with CBD plus silicone and the other half with silicone alone. Researchers wi…

This study tests whether 8 sessions of cognitive processing therapy (CPT), delivered online, can help women and birthing people who have post-traumatic stress disorder (PTSD) from a traumatic childbirth. The trial will enroll 29 participants to see if the therapy is practical, ac…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study will test if guided nature-based therapy, like forest bathing and gardening, can improve the wellbeing of elderly patients with dementia and patients recovering from stroke or brain injury. Researchers will measure changes in agitation, mood, and quality of life in 1,6…

This study tests whether a mindfulness app can help teenagers aged 12 to 17 recover from a mild concussion or traumatic brain injury. The goal is to see if using the app improves quality of life and resilience compared to standard care. The study will involve 362 participants fro…

This study tests whether injecting a patient's own fat into chronic wounds can reduce pain better than standard wound care alone. Sixty-two adults with wounds lasting over 3 months will be randomly assigned to receive either fat grafting plus standard care or standard care only. …

This early-phase study tests whether taking vitamin B6 for up to 31 days can reduce the sharp rise in blood pressure that happens during exercise after a temporary lack of blood flow (like a leg injury). Researchers will measure blood pressure, heart rate, nerve activity, and wal…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study will compare three types of anesthesia for people having ankle surgery: total intravenous anesthesia with a nerve block, general anesthesia with a nerve block, and spinal anesthesia. The goal is to see which method allows patients to recover and leave the hospital the …

This study tests whether a gentle electrical current applied to the spinal cord (transcutaneous spinal cord stimulation) during assisted cycling can improve leg movement, reduce muscle spasms, and help bladder/bowel control in adults with incomplete spinal cord injury. Forty part…

This study tests a new AI system that adjusts electrical stimulation to the spine in real time while people with spinal cord injury walk. The goal is to improve muscle activation and walking ability compared to standard stimulation. The study involves 7 participants and focuses o…

This study looks at whether abdominal massage and drinking warm water can prevent constipation and improve recovery in people who have had hip fracture surgery. About 81 adults will be randomly assigned to receive massage, warm water, or standard care. The goal is to see if these…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study compares two types of wound dressings—chlorhexidine-impregnated gauze and povidone-iodine dressing—to see which one better prevents infection and speeds up healing in people with fresh, clean-contaminated wounds from an injury. About 176 adults aged 18 to 65 will take …

This study tests whether a special way of talking by nurses can help adults with burns feel less pain and worry during dressing changes. About 62 people will be split into two groups: one gets the special comfort talk, the other gets usual care. The goal is to see if simple, supp…

This study tests a home-based digital rehabilitation program combined with a non-invasive spinal cord stimulation device to improve upper limb function in people with chronic tetraplegia. Nine participants will use a mobile app-guided exercise program with daily stimulation over …

This study tests a new rehab program for adults with severe burns who are on breathing machines. The program uses brain stimulation, virtual reality, and special sedation to try to prevent muscle loss. Thirty patients will be split into two groups: one gets standard care, the oth…

This study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…

This study tests a program called COMA-F, designed to help caregivers of patients with severe acute brain injury manage emotional distress. The program teaches skills to cope with uncertainty and long-term caregiving challenges. Researchers will compare it to a basic education pr…

This pilot study tests whether combining non-invasive brain stimulation (over the cerebellum) with spinal cord stimulation can improve arm and hand function in people with chronic cervical spinal cord injury. Twenty-four participants will receive either both stimulations, spinal …

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with acute ankle sprains heal better and faster. Researchers will enroll 208 people with recent ankle sprains and compare those who get hyperbaric oxygen to those w…

This study tests a personalized version of a therapy called Stepped Care Cognitive Behavioral Therapy for children who have experienced trauma. The therapy is adapted for Latino families and involves caregivers helping their children through a step-by-step process. Researchers wi…

This pilot study tests a personalized version of stepped-care cognitive behavioral therapy for PTSD in Latino children aged 7-12. The therapy involves a caregiver-led first step with therapist support, followed by more intensive therapy if needed. The goal is to see if adapting t…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study tests whether a type of talk therapy called narrative exposure therapy (NET) is practical and helpful for people with psychosis who have experienced trauma. One participant will receive NET sessions and complete questionnaires about their symptoms and experiences. The …

This study tests whether a guided laughter exercise, called Laughie, can help people with second-degree burns feel less pain and anxiety during dressing changes. 88 adults will either watch and mimic a video of their own laughter before the procedure or receive standard care. The…

This study tests whether virtual reality relaxation sessions can help adults with acquired brain injury who live in nursing homes and have emotional or behavioral issues. Three participants will use a multisensory VR device for 15–20 minutes twice a week over 8 weeks. Researchers…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether an AI-powered mobile app can help people with spinal cord injury manage bowel dysfunction. About 34 adults will use the app for 12 weeks to see if it reduces bowel problem scores, shortens bathroom time, and improves quality of life. The goal is to make d…

This study compares two spinal anesthesia methods for hip fracture surgery in people over 50. One method uses a single injection, the other uses a tiny tube to give the medicine in smaller doses. The goal is to see if the tube method causes fewer drops in blood pressure and relat…

This study tests a device called the Verus frame, which supports the leg during surgery to fix a broken shinbone. The goal is to see if it helps surgeons align the bone more accurately. Twenty-five adults with tibial fractures will be enrolled, and their results will be compared …

This study compares two methods to keep the surgical area clear during ankle arthroscopy: using a dilute epinephrine solution versus a traditional tourniquet. About 88 people with chronic ankle instability or ligament injuries will be randomly assigned to one method. The goal is …

This study tests an injection called IS-001 that makes ureters glow under special imaging during robotic colorectal surgery. The goal is to help surgeons see the ureters more clearly and avoid accidentally injuring them. About 146 adults having robotic-assisted colorectal surgery…

This study tests whether listening to music for 20 minutes before a wrist fracture reduction can lower pain and stress. 192 adults will be randomly assigned to hear their favorite music, a therapist-chosen song, or no music. Researchers will measure pain scores, heart rate, and b…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests whether a single 30-60 minute Crisis Response Planning (CRP) session can reduce suicide risk in 120 active-duty military personnel who have had a mild traumatic brain injury (mTBI). Participants will be randomly assigned to CRP or usual care, and researchers will…

This study tests whether focusing on hip muscles or ankle muscles during exercise training better improves leg function in athletes with chronic ankle instability. 36 professional athletes will do a 6-week program targeting either the gluteus medius, gluteus maximus, or ankle mus…

This study tests whether applying platelet-rich fibrin (PRF) — a concentrate made from a patient's own blood — to the mental nerve during jaw fracture surgery can improve recovery of sensation in the chin and lower lip. 40 people with a broken jaw and numbness will be randomly as…

This study tests whether a 4-week exercise program delivered through a smartphone app works as well as supervised sessions with a physical therapist before anterior cruciate ligament (ACL) knee surgery. Sixty-six adults aged 18 to 45 with an ACL tear will be split into three grou…

This study tests whether showing 3D hologram videos during burn dressing changes can reduce pain, anxiety, and fear in patients. 70 adults will be randomly assigned to either watch a hologram or receive standard care. The hologram projects interactive images into the air without …

This study tests a family-centred talking therapy (ACT) for young people aged 11-18 with acquired brain injury and their parents. Up to 6 families will receive 12 online therapy sessions. The goal is to see if the therapy is feasible and can improve emotional wellbeing, psycholog…

This study tests whether wearing a head-cooling device for 28 days can help women ages 18-27 recover from a concussion. Researchers will measure changes in thinking, sleep, mood, and brain inflammation. The goal is to see if cooling the brain speeds up recovery and eases symptoms…

This Phase 2a trial will test whether PT150, a drug that blocks a stress-related receptor, can safely reduce PTSD symptoms in 120 US veterans. Participants will receive either PT150 or a placebo for several weeks, and researchers will track changes in PTSD severity and side effec…

This study looks at whether giving trauma patients personalized information and a voluntary digital follow-up visit (instead of only standard care) helps them have less disability, return to work more often, and feel better overall. About 256 adults admitted to a Norwegian trauma…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…

This study tests a new, non-invasive chest stabilizer for people with multiple rib fractures from blunt chest trauma. The device is worn for 10 days and aims to reduce pain, improve breathing, and prevent lung complications like pneumonia. Researchers will compare it to standard …

This study compares a modern silver foam dressing to a traditional dry silver dressing for chronic wound infections. Researchers will track how much the wound shrinks in two weeks and how many wounds fully heal. The goal is to find which dressing works better and costs less for p…

This study tests whether combining loud sounds and mild electrical stimulation with walking practice can improve walking speed and leg strength in people with chronic spinal cord injury. About 20 adults with incomplete spinal injuries who can stand and have some ankle movement wi…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This early study tests whether delivering small electrical pulses over the skin above the spinal cord, alongside standard therapy, can help people with a recent spinal cord injury regain arm and hand function. Twenty participants will receive either active or sham stimulation dur…

This pilot study tests whether a mobile health app with step-by-step exercise videos can help people recover better after a proximal humerus (shoulder) fracture. Sixty adults with this injury will be split into two groups: one gets standard care, the other gets standard care plus…

This study tests whether using a small vibration tool after wrist fracture surgery can reduce pain and the need for opioid painkillers. One hundred adults who have had surgery for a broken wrist will be randomly assigned to use the vibration tool or not. Researchers will measure …

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This study investigates why severe traumatic brain injury (sTBI) often leads to additional brain damage. Researchers think changes in the gut and immune system may play a key role. They will analyze blood, stool, and other samples from 40 adults with sTBI, as well as from trauma …

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…

This study investigates whether examining liver tissue during a cold preservation technique called hypothermic oxygenated machine perfusion can help predict how well the organ will work after transplant. Researchers will compare biopsies taken before and after perfusion and analy…

This study looks at whether a small pressure sensor placed in the leg during surgery can help doctors spot a rare but serious problem called acute compartment syndrome. Teens aged 10 to 21 with a broken shinbone will have the sensor monitor pressure for at least 18 hours after th…

This study looks at how emotional childhood maltreatment (like verbal abuse or neglect) affects social skills, brain structure, and inflammation in people with bipolar disorder. Researchers will compare 80 people with bipolar disorder and 80 healthy controls, using brain scans, b…

This study looks back at medical records of about 1,400 burn patients treated at a hospital near a border. Researchers want to see if foreign-national patients have different outcomes, such as death rates or need for intensive care, compared to Turkish citizens. No new treatments…

This study looks at how fear of moving the wrist (kinesiophobia) changes over time in adults with a common wrist fracture treated with a cast. Researchers will follow 100 people for 3 months after the cast comes off, measuring pain, grip strength, and wrist function. The goal is …

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study will compare two surgical methods for fixing a specific type of broken thigh bone near the knee in people aged 55 and older. Half the participants will get a single implant (a plate or a rod), while the other half will get two implants (a plate plus either a rod or a s…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study will follow 200 young male soccer players from Villarreal CF for up to 4 years to understand why some get ACL injuries. Researchers will analyze how they jump, their heart rate, genes, and gut bacteria. The goal is to create a tool that gives each player a personalized…

This study tests a program to help Hispanic teen soccer players get timely knee surgery. Many face barriers like language and insurance issues that delay care. The program includes an educational talk and a bilingual navigator to guide families. The goal is to see if this approac…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This pilot study tests whether a single 75mg dose of amitriptyline can reduce the release of microvesicle particles (tiny substances) from skin after a very small, controlled burn. Twenty healthy adults will receive either amitriptyline or a placebo, then a small heated rod creat…

This study looks at how different ways of packaging a person in a rescue litter affect their breathing. Researchers will measure lung function in 24 healthy adults while lying down, on their side, and upright in a vacuum mattress. The goal is to find the best position to keep air…

This study aims to see if special MRI scans can help predict how well people recover from moderate to severe traumatic brain injury (TBI). Researchers will scan 100 adults aged 18 to 60 soon after their injury and then check their recovery one year later. The goal is to find brai…

This study looks at how environmental factors like heat, cold, and pollution affect wounds, mental health, and drug use in homeless people in Augsburg. Researchers will compare wound care from a mobile unit to a hospital clinic, and use saliva tests to check drug use. The goal is…

This study is creating and testing a Turkish version of a questionnaire that measures how people recover from ankle fractures. Researchers will ask 150 adults with ankle fractures to fill out the new Turkish questionnaire along with two other standard forms. The goal is to make s…

This study will collect blood samples, brain scans, and medical information from 270 people with penetrating brain injuries. The goal is to create a large research database that scientists can use to better understand these injuries and improve future treatments. Participants mus…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study tests whether using a special ventilator monitor to track lung volume during one-lung surgery, combined with lung-opening maneuvers, can prevent lung collapse after surgery. 44 adults having lung surgery will be randomly assigned to either standard care or the monitori…

This study tests a non-invasive decision support system called CRUISE that helps medics identify and manage shock in critically ill adults during helicopter transport. Researchers will compare the system's recommendations to standard care given by paramedics. The goal is to see i…

This study looks at a simple idea: during a liver transplant, the first blood that flows into the new liver may contain harmful substances. By discarding that blood before connecting the liver to the patient's circulation, doctors hope to reduce heart, kidney, and liver problems.…

This trial tests a software device called AI-TRiPS that uses real-time data from ambulances to predict the risk of death, bleeding, kidney injury, and need for blood transfusion in trauma patients. The tool displays these predictions to hospital trauma teams before the patient ar…

This study surveys physiotherapists and team doctors in Sweden's top ice hockey leagues to understand how they perceive and manage hand and wrist injuries. About 50 medical staff will answer questions on injury frequency, underreporting, and return-to-play decisions. The goal is …

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study tests whether a structured, supervised exercise program can help adults recover from serious leg fractures. About 40 people who had surgery for a broken thigh or shin bone will either do the exercise program or get usual care. The main goal is to see if the program is …

This study looks at how a gas called nitric oxide, given through a mask or nasal tubes, changes the way air and blood flow match in the lungs of people with ARDS (a serious lung injury). Researchers will use a special imaging technique (EIT) to see these changes right away. The g…

This study tests a program called EMBER designed to help women who have experienced intimate partner violence build resilience and improve their well-being. Eight women will take part in the program and answer weekly questionnaires about their resilience and health. Researchers w…

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study looks at whether adding cognitive behavioral therapy (CBT) to standard neck and balance rehab helps people with persistent symptoms after a mild concussion. It will include 34 adults aged 18–70 who still have dizziness, neck pain, or headaches at least two weeks after …

This study aims to translate and adapt an English scale (EmNSA) into French to better assess sensation in the legs of adults with acquired brain injury. Researchers will test the new French version on 50 patients to ensure it is accurate and reliable. The goal is to provide a val…

This study will check if an Arabic version of the Michigan Hand Outcomes Questionnaire works well for people who have had hand burns. About 100 adults with second-degree burns on their dominant hand will fill out the questionnaire twice, one week apart. Researchers will see if th…

This study looks at how well hospitals with limited resources treat severe bleeding from torso injuries. Researchers will track 716 adults to see if delaying fluid resuscitation affects survival and complications. The goal is to learn what works best in these settings, not to tes…

This study follows 236 severely burned patients who received lab-grown skin grafts (CEA or CDEA) between 1985 and 2023 at Swiss burn centers. Researchers will measure scar quality, skin thickness, elasticity, and check for skin tumors. The goal is to understand long-term outcomes…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study looks at two different methods for setting the pressure on a breathing machine (ventilator) in people with a serious lung condition called ARDS. The goal is to see which method improves oxygen levels better over 24 hours. About 52 adults with moderate to severe ARDS wi…

This study checks on children who had a moderate to severe head injury years ago to see if they have any lasting hormone or growth problems. Researchers will call participants for a 15-minute interview to measure their height and ask about symptoms. The goal is to learn how commo…

This study will compare two common anesthesia methods—inhaled gas versus intravenous drugs—to see which one causes less lung injury after major surgery in patients with sepsis. About 480 adults with sepsis who need surgery will be randomly assigned to one of the two groups. Resea…

This study looks at whether pelvic alignment differs between male athletes with and without chronic ankle instability. Researchers will measure ankle stability, balance, and pelvic angles in 38 football players. The goal is to better understand how the pelvis and ankle work toget…

This study will test a new positioning aid called Tru-Vu that helps radiographers take clearer wrist x-rays. About 1,800 adults with wrist injuries or arthritis will be included across three different healthcare centers in Newfoundland and Labrador. Researchers want to see if the…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This study tests a new method that uses carbon dioxide measurements to help doctors set breathing machines more precisely for brain injury patients. The goal is to reduce lung damage while keeping the patient stable. The study will include 30 adults in a neuro-intensive care unit…

This observational study will collect blood samples from 25,000 adult ICU patients in Sweden to look for genetic variants linked to severe illness from infections, sepsis, or organ failure. Participants also give samples 3-6 months after leaving the hospital. The goal is to build…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…

This study will train over 1,800 lay first responders—like taxi drivers and shopkeepers—in Cameroon to provide basic first aid and safe transport for injured people. Researchers will compare survival rates before and after the training program. The goal is to see if a data-driven…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study looks at whether giving both food assistance and psychological counseling helps young adults aged 18-25 who face food insecurity and mental health issues. Participants will receive weekly food aid for a year, and half will also get twice-monthly therapy for six months.…

This pilot study will use a very small camera, called a nano-arthroscope, to look inside the ankle joint of 25 people who have a severe type of ankle fracture (pilon fracture). The goal is to find out how often hidden cartilage injuries occur and whether seeing them changes the s…

This study looks at how different positions and positioning devices affect pressure on areas like the heels, tailbone, elbows, and back of the head in burn patients. Researchers will use a special pressure-sensing mat to find which setups create the least pressure. The goal is to…

This study tests a digital tool called WoundPilot that guides nurses through wound assessment and treatment choices. Forty primary care nurses will review wound cases with or without the tool, and their decisions will be compared to expert recommendations. The goal is to see if t…

This study will test a new program designed to help people who have been hospitalized for a physical injury. The program connects survivors with resources to meet their medical and social needs. Researchers will interview 25 participants and track which resources they use to see …

This study looks at how inflammation in the nervous system affects pain and recovery after elbow fractures or dislocations. Researchers will take blood samples from 60 adults before and after surgery to measure specific inflammatory markers. The goal is to better understand why s…

This study aims to improve balance problems after a mild traumatic brain injury (concussion). Researchers will develop a new exercise program that focuses on how the body responds to imbalance, and compare it to standard balance therapy. The study will involve 80 adults aged 18-6…

This observational study will look at how fear of movement (kinesiophobia) relates to independence, fear of falling, pain, and mood in 70 adults with paraplegic spinal cord injury. Participants will fill out questionnaires during one visit. The goal is to better understand these …

This study will test whether playing selected music through headphones can help people in a coma after a severe traumatic brain injury recover cognitive function. Researchers will compare 35 patients who receive music therapy to similar patients from the past who did not. They wi…

This study tests a robotic system that monitors vital signs in patients with severe brain injury. The robot works alongside standard care to detect early signs of decline. Researchers will measure how usable and acceptable the robot is for staff and patients. The goal is to see i…

This study looks at how quickly people with paraplegic spinal cord injury can mentally picture moving their hands or feet compared to healthy individuals. Researchers will use a computer task where participants identify left or right hand/foot images. The goal is to understand ho…

This study will see if an AI chatbot app is practical and acceptable for family caregivers of people with traumatic brain injury, dementia, or Huntington disease. About 60 caregivers will use the app for 8 weeks, focusing on physical and mental health. They will complete surveys …

This study will collect data from 500 Danish cancer patients who need repeat radiation therapy (reirradiation). Researchers will track side effects, tumor control, and survival to build a database that can guide safer treatment in the future. The goal is to help doctors decide wh…

This observational study will follow 250 adults treated in the emergency department for major trauma. Researchers want to see if early factors like thinking flexibility, social support, and stress levels can predict who develops PTSD within 6 months. Participants fill out questio…

This study looks back at medical records of 60 adults who had surgery for severe pelvic fractures. It compares the standard open surgery (large cut) with a newer minimally invasive method (small cuts) to see which leads to better healing, fewer complications, and faster return to…

This study aims to identify biological markers that could predict radiation-induced intestinal injury in people receiving abdominal radiotherapy. Researchers will observe 220 adult patients who are about to start high-dose radiation. By analyzing samples and outcomes, they hope t…

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This study looks at how two common leg injuries—ankle sprains and kneecap pain—affect balance in different directions. Researchers will measure stability in 90 people using a special balance machine. The goal is to find out if each injury causes a unique type of balance problem, …

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This early-stage study tests whether a device that gently stimulates a nerve in the ear is safe and practical for people with moderate to severe traumatic brain injury. Sixteen adults will receive either real or sham stimulation while in the hospital. The main goal is to see if t…

This study will look back at medical records of 800 children aged 0-18 who came to the emergency room with a mild traumatic brain injury and had a head CT scan. Researchers want to see if routine blood tests (like white blood cell count, CRP, and glucose) can predict whether the …

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study looks at how pain, tiredness, muscle strength, balance, and quality of life are connected to injury risk in volleyball players. Researchers will test 28 professional players using movement screens and surveys. The goal is to understand which factors make players more l…

This study will watch 50 children under 15 with a specific elbow fracture to see how often blood vessel injuries happen and what factors make them more likely. Researchers will also look at how different treatments work. The goal is to better understand and manage these complicat…

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study looks at whether certain proteins in the blood can signal brain injury in children who have heart surgery with a heart-lung machine. Researchers will measure these proteins before and after surgery and compare them to the child's brain function. The goal is to find a s…

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study looks at whether a medicine called iloprost can be given to people with severe frostbite (grades 3-4) in remote, high-altitude places like Mount Everest. The goal is to see if it's safe and practical to start treatment before reaching a hospital. Ten adults with severe…

This study will follow 10 people aged 6 to 75 with chronic traumatic brain injury who choose to get MUSE stem cell therapy outside the U.S. Researchers will not give any treatment but will track safety, brain function, and quality of life for 12 months. The goal is to gather real…

This study looks at whether an EEG (a brain wave test) can better tell the difference between people who are unresponsive but awake and those who show minimal signs of awareness after a severe brain injury. About 42 adults will take part. The goal is to see if brain responses to …

This study looks at how well people recover 12 months after an Achilles tendon rupture treated without surgery, using a specific rehabilitation program called the SMART protocol. Researchers will measure ankle strength with a machine and ask participants about their daily functio…

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study will test a new way to assess concussion in football players by having them perform cognitive and motor tasks right on the field, like counting whistles while dribbling. Researchers aim to standardize these 'ecological' tests so they can be used as a baseline before th…

This study at Montpellier University Hospital will look at whether low muscle mass and strength before hip replacement surgery affects how well people aged 75 and older regain their independence. About 20 volunteers will have blood tests, scans, and a tiny muscle sample taken dur…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study will look back at the medical records of 50 people with spinal cord injuries treated over the last five years. Researchers want to understand common causes of injury, levels of paralysis, and what complications patients faced, such as pressure sores or infections. The …

This study watches real conversations between healthcare staff and people with dementia after hip fracture surgery. The goal is to find which words and phrases work best to encourage patients to stand or walk early. Researchers will record up to 50 care sessions on hospital wards…

This study looks at 400 severely injured patients treated by emergency medical teams in the Paris region. It aims to see if the time spent on scene before going to the hospital affects whether patients survive the first 24 hours. The goal is to find ways to improve emergency care…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This study will test a new classification system (BICEP) to grade bladder injuries that happen during a common surgery for bladder cancer called TURBT. Researchers will observe 1,000 patients to see how often injuries occur, how severe they are, and how doctors manage them. The g…

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This study tests a new questionnaire called PET (Patient Experience in Telehealth) to see if it accurately measures how patients feel about telemedicine visits. Researchers will ask 200 adults who had a telemedicine appointment at an Italian hospital to fill out the survey. The g…

This study follows 40 adults with serious burn injuries to collect blood, tissue samples, and medical record data. Researchers will look for patterns that could help predict who will develop sepsis or other complications. The goal is to build a computer-based 'digital twin' model…

This study follows 80 adults with serious burns to understand how their bodies respond to injury and treatment. Researchers collect blood and tissue samples and review medical records to find patterns that might predict sepsis and other complications. The goal is to build compute…

This exploratory study will use an upright MRI scanner to take 3D images of the bladder in 20 people—some with spinal cord injury who use catheters, and some healthy volunteers. The goal is to understand how the bladder and surrounding structures change shape during catheter use …

This study looks at whether activating the breathing muscles can help professional male football players recover better after exercise. Thirty players will be randomly assigned to one of three groups: electrical stimulation of the phrenic nerve, deep breathing against a resistanc…

This pilot study will look at how well bone heals after a tooth is removed and a bone graft is placed, comparing smokers and non-smokers. Twelve adults will be enrolled to measure bone width and height, and analyze gene activity and tissue samples. The goal is to gather initial d…

This study looks at whether a special hospital program for older adults (65+) who need surgery can improve their outcomes. Researchers will compare patients treated before and after the program started, tracking deaths and complications within 28 days. About 150 participants will…

This study will analyze data from a pediatric trauma registry to understand injury patterns, outcomes, and what factors predict how severe an injury is. Researchers will look at records of 40 children under 18 who came to the hospital with a traumatic injury. The goal is to learn…

This study looks at whether a steroid called dexamethasone can improve recovery in people with traumatic brain injury who develop brain swelling. Researchers will follow 280 adults aged 18 to 70 who already receive this treatment as part of their care, comparing their outcomes to…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study examines how much the tensor fascia latae muscle is damaged during hip replacement surgery through the front approach. Researchers will compare the amount of muscle damage to how well patients recover at 6 weeks and 6 months. The goal is to understand if less muscle da…

This study tests whether giving metoclopramide alone or with dexamethasone can speed up stomach emptying in trauma patients needing emergency surgery. Using bedside ultrasound, researchers will measure stomach contents to see which drug works better. The goal is to reduce the ris…

This study aims to find the smallest meaningful change in the push-off test for people recovering from a broken wrist (distal radius fracture). Researchers will measure wrist movement, grip strength, and pain in 109 adults aged 18 to 65. The goal is to help doctors better underst…

This study looks at 100 elderly patients with hip fractures to see if quick, easy tests like muscle ultrasound, handgrip strength, and routine blood work can predict frailty. Frailty affects recovery after surgery, so finding a fast way to measure it could help doctors provide sa…

This study tests whether a special training package and checklist can help doctors better identify serious injuries on CT scans of trauma patients. About 300 medical professionals will review sets of scan images, some with the checklist and some without. The goal is to see if the…

This study will use a new 3D imaging device (3D-EIT) to see if it can detect a pattern called 'cyclic on-off switching' of blood flow in the lungs of 40 adults with moderate to severe ARDS who are on mechanical ventilation. The goal is to validate whether this non-invasive, bedsi…

This study aims to create an early warning system for osteoporotic vertebral compression fractures (OVCF) by combining Traditional Chinese Medicine (TCM) patterns with standard risk factors like bone density. Researchers will follow 200 adults aged 50-79 with new fractures or low…

This study tests whether mild hypothermia (cooling the body to about 33°C) during coronary artery bypass grafting protects the brain better than normal temperature (about 36.5°C). Researchers will use advanced brain scans and blood tests to measure brain injury in 160 adults unde…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study will closely monitor 180 adults with sepsis-related acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers will take fluid samples from the lungs and blood at several time points to measure inflammation and injury markers. The goal is to …

This study tests whether gentle, non-invasive brain stimulation can help people with traumatic brain injury (TBI) remember locations better. Participants will use a virtual reality game to find objects while their brain is stimulated or not. The goal is to see if stimulation impr…

This study tests a new peer support program for adults recovering from serious injuries like car crashes, burns, or amputations. The program pairs survivors with trained peers who have been through similar experiences, offering support from hospital to home. The goal is to see if…

This study compares two types of numbing medicine for upper limb surgery: a standard one and a longer-acting version. Researchers want to see how quickly the diaphragm (the main breathing muscle) recovers after the nerve block. 120 adults having arm or hand surgery will be split …

This study looks at 126 adults with serious injuries from accidents or violence. Researchers want to see if a simple ultrasound of a large vein (the IVC) can detect low blood volume as reliably as a standard blood test (lactate). If the two measures match, doctors might use the u…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study compares two methods—mixed reality goggles and ultrasound—to help surgeons mark exactly where ribs are broken before surgery. About 30 adults with three or more broken ribs will take part. The goal is to see which method is more accurate and faster.

This study will use a special brain scanner to see how virtual reality (VR) affects pain in children aged 6-17 with burns. Four children will have their brain activity measured during burn dressing changes, both with and without VR. The goal is to find brain markers that show whe…

This observational study from the University of Nottingham aims to find out which factors predict chronic pain after a serious limb injury. Researchers will follow 450 major trauma patients with at least one broken limb for 6 months, asking them about their pain at 3 and 6 months…

This study looks at 40 veterans with chronic spinal cord injury to find any remaining nerve connections below their injury. Researchers will use MRI scans and non-invasive stimulation to measure these connections. The goal is to understand who might benefit from future treatments…

This study will follow 100 adults aged 65 and older who have a broken shoulder (proximal humerus fracture). Some will receive surgery (plates, screws, or a shoulder replacement) and others will be treated without surgery. Researchers will measure shoulder movement, pain, and dail…

This study looks at 150 people who have had a brain injury from a stroke, bleed, or trauma. Researchers will track their sleep quality and mental health symptoms for up to a year using wrist monitors, brain activity sensors, and questionnaires. The goal is to understand if poor s…

This study will enroll 50 people with severe brain injuries to see if combining different types of monitoring—like blood sugar levels, brain waves, and blood flow—can help predict how well they will recover. Researchers will follow participants for 6 months to check their neurolo…

This study checks if a smartphone app can reliably measure calf muscle strength in people recovering from Achilles tendon rupture or ankle sprain. Researchers will compare results from 70 participants (patients and healthy controls) using the app during calf raise exercises. The …

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…

This study tests whether a hand rehabilitation device called ReHandyBot, paired with a smartphone app called RehabCoach, can help people recover after a stroke, traumatic brain injury, or orthopedic problem. Thirty participants will first use the device under supervision at a cli…