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Could a common nausea drug shield ARDS lungs from further harm?

NCT ID NCT07588217

Not yet recruiting Disease control Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal Source: ClinicalTrials.gov ↗

First seen May 16, 2026 · Last updated Jun 10, 2026 · Updated 3 times

Summary

This study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs and causing additional injury. The trial will enroll 76 adults with moderate-to-severe ARDS and randomly assign them to receive ondansetron or a placebo four times daily, monitoring safety and feasibility for a larger future study.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hopital du Sacré-Coeur de Montréal

    Montreal, Quebec, H4J 1C5, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME) INVASIVE MECHANICAL VENTILATION PATIENT-SELF INFLICTED LUNG INJURY