Which IV drug eases concussion symptoms best? new trial aims to find out

NCT ID NCT07634393

Not yet recruiting Symptom relief Sponsor: Montefiore Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two intravenous medications—metoclopramide and acetaminophen—to see which one better relieves acute concussion symptoms like headache, dizziness, and nausea in emergency room patients. Researchers will enroll 200 adults with mild head injuries and track their symptoms over a week. The goal is to provide clearer guidance on which drug works best for post-concussion care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metoclopramide and acetaminophen
What this could lead to: If it works, this could point toward a better standard treatment for concussion symptoms in the emergency room.
What could go wrong: This is a small, early-phase trial with only 200 participants, so results may not apply to everyone. Both drugs are already used, so no major new risks are expected, but the study may not find a clear winner.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Craniocerebral Trauma head injury Post-Concussion Syndrome traumatic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONCUSSION POST SYNDROME HEAD TRAUMA INJURY

Contacts and locations

Locations

Montefiore Medical Center

New York, New York, 10467, United States

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