Concussion headache drug trial stalls early

NCT ID NCT04226365

Terminated Symptom relief Sponsor: Lancaster General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether nortriptyline, a common antidepressant, could ease headaches after a concussion better than a placebo. It included teens aged 13-21 with recent head trauma. The trial was stopped early after enrolling only 8 people, so the results are not reliable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nortriptyline (Pamelor)
What this could lead to: If it works, this could point toward a faster way to ease headaches after a concussion.
What could go wrong: The trial was terminated early with only 8 participants, so results are very limited. It may not show a clear benefit or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Headache Post-Concussion Syndrome Post-Traumatic Headache traumatic brain injury traumatic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONCUSSION POST SYNDROME HEADACHES POSTTRAUMATIC MILD TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Penn Medicine Lancaster General Health

Lancaster, Pennsylvania, 17602, United States

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