Concussion headache drug trial stalls early
NCT ID NCT04226365
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether nortriptyline, a common antidepressant, could ease headaches after a concussion better than a placebo. It included teens aged 13-21 with recent head trauma. The trial was stopped early after enrolling only 8 people, so the results are not reliable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nortriptyline (Pamelor)
What this could lead to
If it works, this could point toward a faster way to ease headaches after a concussion.
What could go wrong
The trial was terminated early with only 8 participants, so results are very limited. It may not show a clear benefit or apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Penn Medicine Lancaster General Health
Lancaster, Pennsylvania, 17602, United States