Can pressurized oxygen ease persistent concussion woes?

NCT ID NCT05173818

Completed Symptom relief Sponsor: Essentia Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help adults with persistent post-concussion symptoms like headaches, fatigue, and memory problems. Twenty participants with mild traumatic brain injury received either real treatment or a sham procedure over 40 sessions. The goal was to see if the therapy improves thinking skills and reduces a brain-damage marker in the blood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen therapy
What this could lead to: If it works, this could offer a new treatment option for people with long-lasting concussion symptoms that haven't improved with other therapies.
What could go wrong: This is a small, early-phase study with only 20 participants, so results may not apply to everyone. The sham control also involves some pressure, which could reduce the apparent benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Charcot-Marie-Tooth disease type 1F Post-Concussion Syndrome traumatic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONCUSSION POST SYNDROME PERSISTENT POST-CONCUSSIVE SYNDROME

Contacts and locations

Locations

Essentia Health

Fargo, North Dakota, 58103, United States

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