Can pressurized oxygen ease persistent concussion woes?
NCT ID NCT05173818
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help adults with persistent post-concussion symptoms like headaches, fatigue, and memory problems. Twenty participants with mild traumatic brain injury received either real treatment or a sham procedure over 40 sessions. The goal was to see if the therapy improves thinking skills and reduces a brain-damage marker in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyperbaric oxygen therapy
What this could lead to
If it works, this could offer a new treatment option for people with long-lasting concussion symptoms that haven't improved with other therapies.
What could go wrong
This is a small, early-phase study with only 20 participants, so results may not apply to everyone. The sham control also involves some pressure, which could reduce the apparent benefit.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Essentia Health
Fargo, North Dakota, 58103, United States