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New Wound-Cleaning method may let surgeons close incisions right away after severe appendicitis

NCT ID NCT07688109

Disease control Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This trial tests whether closing the surgical wound immediately after cleaning it with a special high-pressure irrigation technique (HIEDI) is as good as or better than waiting a few days to close it. The study involves 200 people aged 12 and older who have open surgery for complicated appendicitis (where the appendix has burst or become gangrenous). Researchers will compare infection rates, healing, hospital stay length, and patient satisfaction over 30 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-Efficiency Incision and Drainage with Irrigation (HIEDI) technique
What this could lead to
If primary closure with HIEDI works as well as delayed closure, patients could avoid a second surgery and have shorter hospital stays.
What could go wrong
This is a single-center study in a resource-limited setting, so results may not apply elsewhere. Infection rates could still be higher with immediate closure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 12 years and older * Intraoperative diagnosis of complicated appendicitis (perforation or gangrene) * Undergoing open appendectomy via McBurney or Rocky-Davis incision * Ability to provide written informed consent (patient or legal guardian for minors) * Availability for 30-day follow-up Exclusion Criteria: * Generalized peritonitis requiring midline laparotomy * Immunocompromised status (e.g., chronic corticosteroid or immunosuppressive therapy, diagnosed HIV infection) * Poorly controlled diabetes mellitus (Hemoglobin A1c \[HbA1c\] greater than 8%) * Pregnancy * Concurrent malignancy * American Society of Anesthesiologists (ASA) physical status classification IV or V * Laparoscopic appendectomy

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Conditions

The condition(s) this trial relates to.

appendicitis injury Postoperative Complications Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Appendicitis Postoperative complications Surgical wound infection Wound healing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Al-Gumhori Teaching Hospital

    Sanaa, Yemen

  • Al-Kuwaint University Hospital

    Sanaa, Yemen

  • Al-Thawra Modern General Hospital

    Sanaa, Yemen

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