Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a different anesthesia approach tame inflammation after chest surgery?

NCT ID NCT07800767

Knowledge-focused Sponsor: Koşuyolu Kartal Heart Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study looks at two ways of managing anesthesia during non-intubated video-assisted thoracoscopic surgery (NIVATS), a type of chest surgery where patients breathe on their own without a breathing tube. Researchers will review records of 120 adults who had this surgery to create a pericardial window for pericardial effusion. They will compare patients who received sedation with systemic opioid painkillers versus those who received sedation plus a regional nerve block. The goal is to see if one approach leads to a smaller rise in a blood marker of inflammation (neutrophil-to-lymphocyte ratio) and better early recovery after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two anesthesia management approaches: procedural sedation with systemic opioid analgesia versus procedural sedation with thoracic regional analgesia (paravertebral, erector spinae, or serratus anterior/intercostal plane block). No intervention assigned by investigators.
What this could lead to
If one anesthesia approach proves better, it could guide choices that reduce post-surgery inflammation and speed recovery for patients undergoing non-intubated chest surgery.
What could go wrong
This is a retrospective review of past records, not a controlled experiment, so results may be influenced by unmeasured factors. The study is small and single-center, so findings may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive adult patients who underwent non-intubated (spontaneous ventilation) video-assisted thoracoscopic creation of a pericardial window for pericardial effusion at a single tertiary cardiovascular training and research hospital. All eligible cases identified in the hospital records within this period will be included; no sampling or selection beyond the eligibility criteria will be applied.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 80 years * Underwent non-intubated video-assisted thoracoscopic surgery with spontaneous ventilation for creation of a pericardial window for pericardial effusion at the study centre * American Society of Anesthesiologists (ASA) physical status I to IV * Available preoperative complete blood count within 24 hours before surgery and routine morning complete blood count on postoperative day 1 * Anaesthesia management module classifiable as Group A or Group B from the perioperative records Exclusion Criteria: * Age under 18 years or over 80 years * Pregnancy * Documented poor general condition or haemodynamic instability before surgery * Requirement for inotropic or vasopressor support before surgery * Intensive care unit stay exceeding 24 hours before surgery * Missing preoperative or postoperative day 1 complete blood count * Haematological malignancy, active systemic infection, or ongoing corticosteroid or immunosuppressive therapy at the time of surgery * Anaesthesia management not classifiable into either predefined module

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Inflammatory response after surgery are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

agnosia pericardial effusion Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inflammatory response after surgery Non-intubated anesthesia Pericardial effusion Postoperative complications Procedural sedation and analgesia Video assisted thoracic surgery (VATS)

Contacts and locations

Locations

  • Kosuyolu Heart Training and Research Hospital

    Istanbul, Kartal, 34862, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.