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Blood pressure target during bypass surgery may cut complications

NCT ID NCT07787364

Disease control Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time

Summary

This trial tests two strategies for managing blood pressure during off-pump coronary artery bypass grafting (a type of heart surgery done without a heart-lung machine). It asks whether keeping average blood pressure at 65 mm Hg or higher during surgery reduces the chance of major complications or death within 30 days, compared to letting clinicians decide. It also compares two anesthetics, remimazolam and propofol, for stability of blood pressure and heart rate. Adults scheduled for elective bypass surgery will be randomly assigned to one of four groups, combining one blood pressure strategy with one anesthetic, and followed for recovery and longer-term health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Targeted blood pressure management (keeping mean arterial pressure at 65 mm Hg or higher) and remimazolam (an anesthetic) compared to liberal blood pressure management and propofol
What this could lead to
If effective, targeted blood pressure control during off-pump bypass surgery could reduce major complications and deaths after surgery, and remimazolam might offer more stable anesthesia.
What could go wrong
This is a single-center trial, and results may not apply broadly. The benefits are uncertain, and there are risks from surgery and anesthesia, including potential side effects of the drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 416 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years; 2. Scheduled for elective, isolated, primary OPCAB under general anaesthesia; 3. Agree to complete the baseline assessments and postoperative follow-up required by the study protocol. Exclusion Criteria: 1. Known allergy to remimazolam, benzodiazepines, propofol, etomidate, sufentanil, cisatracurium; 2. Pregnancy or breastfeeding; 3. Life expectancy \<30 days because of a noncardiac condition; 4. Severe cognitive, language, hearing, visual, or communication impairment precluding completion of the required CAM/CAM-ICU or MoCA assessments; 5. Preoperative AKI within 7 days before surgery, defined by any Kidney Disease: Improving Global Outcomes (KDIGO) criterion: an increase in serum creatinine of ≥0.3 mg∙dL-1 (≥26.5 µmol∙L-1) within 48 hours; an increase to ≥1.5 times a known or presumed baseline value within 7 days; or urine output \<0.5 mL∙kg-1∙hour-1 for at least 6 hours; 6. Maintenance hemodialysis or peritoneal dialysis; 7. Delirium at the preoperative baseline assessment; 8. Concurrent participation in another interventional clinical trial that could interfere with the study interventions or outcome assessment; 9. Other condition considered by the investigator to make participation inappropriate.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease Postoperative complications

How to take part

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  1. The official record

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