Could a common numbing drug shield Babies' lungs after heart surgery?

NCT ID NCT07499154

Not yet recruiting Disease control Sponsor: The Children's Hospital of Zhejiang University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether giving the numbing drug lidocaine during heart surgery can reduce lung damage in infants. 320 babies under 1 year old having heart surgery will receive either lidocaine or a placebo. The goal is to see if lidocaine lowers the severity of lung injury after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lidocaine
What this could lead to: If it works, this could provide a simple, low-cost way to protect infants' lungs after heart surgery, reducing time on a ventilator and in the ICU.
What could go wrong: This is a Phase 4 trial, but lidocaine is already used for other purposes. The benefit for lung injury is not proven, and there is a risk of side effects like heart rhythm problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury congenital heart disease Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LUNG INJURY CONGENITAL HEART DISEASE POSTOPERATIVE PULMONARY COMPLICATIONS

Contacts and locations

Locations

Children's Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310052, China

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