Injury

This trial is testing a lab-grown skin substitute called denovoSkin in children with deep burns. The engineered skin is made from the child's own cells and is compared to the standard treatment of using a split-thickness skin graft. The goal is to see if denovoSkin can cover burn…

This study tests a special nail made from a fiber-reinforced material that integrates with bone over time, instead of staying in the body like metal. Ten people with knee fractures will get the implant and be followed for up to two years. The goal is to see if it reduces pain and…

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This trial tests whether a brain-computer interface (BCI) can guide electrical stimulation to improve leg muscle activation and walking in people with spinal cord injury. Participants imagine moving their ankles while a device reads their brain signals and triggers electrical sti…

This trial tests whether proton therapy, a more precise form of radiation, causes fewer long-term bowel side effects than standard photon therapy in men with high-risk prostate cancer. Participants receive the same radiation dose and schedule, but one group gets protons and the o…

This trial tests a procedure that uses tiny full-thickness skin samples, called microcolumns, to cover open wounds. The goal is to see if this approach can help the wound heal while avoiding the extra scar that comes from traditional skin grafts. Participants are people aged 8 to…

This study tests satralizumab, a drug that calms inflammation, in 30 children aged 8 to 17 with Duchenne muscular dystrophy. The goal is to see if it improves bone density and muscle function. Participants receive injections for several months while continuing standard steroid th…

This trial is testing two different cup designs for total hip replacement, both paired with the same stem, to see which one gives patients better hip function and less pain. About 120 people with hip arthritis or related conditions will be randomly assigned to receive either the …

This trial tests a gel made from the enzyme SN514 to see if it can safely and effectively remove dead tissue from deep partial-thickness burns. Adults with suitable burns will receive daily applications of the gel for up to seven days, with different concentrations tested in smal…

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This trial tests whether a culturally adapted program of case manager support can improve survival, reduce hospital readmissions, and boost quality of life for adults recovering from accidental burn injuries in Pakistan. Participants receive up to eight sessions with a case manag…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug leads to better functio…

This trial tests whether custom-made PEEK (a high-performance plastic) plates are as good as or better than custom titanium plates for repairing fractures of the lower jaw. Twenty adults with a broken jawbone will receive one type of plate during surgery. Researchers will use 3D …

This trial compares two treatments applied during surgery to help heal jaw bone damage caused by bisphosphonates or similar drugs. One is an oxygen-based gel, the other is a membrane made from the patient's own platelets. Researchers will measure how completely the bone and soft …

This trial tests whether a focused form of brain stimulation called high-definition transcranial direct current stimulation (HD-tDCS) can improve arm and hand function in people with cervical spinal cord injury. Participants receive either HD-tDCS or conventional stimulation duri…

This trial tests three ways to treat hypergranulation tissue—excess flesh that can slow healing in traumatic wounds. Adults with non-infected wounds will receive either silver nitrate, triamcinolone, or both treatments in sequence. The goal is to see which approach best reduces t…

This trial tests whether a negative pressure wound therapy (NPWT) dressing — a special vacuum-sealed bandage — can reduce surgical site infections and improve scar appearance compared to a standard dressing in people who have had a midline laparotomy (a large abdominal incision).…

This study looks at whether a combination of ibogaine-magnesium, 5-MeO-DMT, magnetic e-Resonance therapy (MeRT), and physiological supplements can help special operations veterans with PTSD, depression, suicidal thoughts, and cognitive problems from traumatic brain injury. Partic…

This trial tests a procedure called expansile duraplasty, where surgeons open the spinal cord's covering and sew in a patch to give the swollen cord more room. Researchers will compare recovery in 66 adults who receive this extra surgery versus those who get standard care alone. …

This study follows 300 people who receive a hip replacement using either the Vivacit-E or Longevity liner, both made of a special plastic designed to last longer. The goal is to see how well these liners hold up over time, measuring how many are still in place without needing rep…

This trial investigates whether tranexamic acid (TXA), a drug that helps control bleeding, can reduce the need for blood transfusions in people over 60 who have hip fractures and require surgery. Participants receive either TXA or a placebo (saline) before, during, and after surg…

This study tests if a gentle, non-invasive stimulation on the ear can help adults with moderate to severe burns recover faster. Researchers will measure inflammation and physical function in 50 participants who receive either standard physiotherapy or physiotherapy plus the ear s…

This study evaluates a free, student-run occupational therapy clinic for uninsured or under-insured adults with spinal cord injury or disease. Participants attend group sessions and one-on-one therapy covering bowel/bladder management, community mobility, and advocacy. Researcher…

This study tests whether combining spinal cord stimulation with electrical muscle stimulation can improve cough strength in people who recently had a spinal cord injury. Participants will receive either real or sham stimulation during cough training sessions over several weeks. T…

This trial investigates how different amounts of robotic gait training using an exoskeleton, combined with brain stimulation, affect walking ability in people with spinal cord injury. Participants with motor incomplete injuries will train during inpatient and outpatient rehab. Th…

This study tests whether a set of standard guidelines for managing external ventricular drains (EVDs) can improve nurses' practices and reduce complications in adults with traumatic brain injury. The guidelines include steps like regular checks, proper dressing changes, and caref…

This study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…

This study tests whether adding a fractional CO2 laser to compression bandages helps heal leg wounds after surgery. About 80 adults with leg wounds from skin excisions will be randomly assigned to receive compression bandages alone or with laser treatment. The goal is to see if t…

This early-stage trial tests whether injections of tiny particles from umbilical cord stem cells are safe for people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study will enroll 18 adults whose symptoms haven't improved after surgery …

This study aimed to test a finger prosthetic system called Point Mini in 5 children aged 5-15 with partial hand loss. The device uses ratcheting mechanical digits to help with gripping and lifting tasks. However, the trial was withdrawn before any participants were enrolled, so n…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This study tests a special titanium implant, called iFuse-3D, along with screws to treat pelvic fractures in people aged 60 and older. The goal is to see if this surgery helps patients get back to their usual walking ability by the time they leave the hospital. Fifty participants…

This study tests a 4-month in-home rehabilitation program called HOME for Us for people who have had a traumatic brain injury (TBI) at least one year ago and their family caregivers. The program involves eight sessions with an occupational therapist, focusing on adapting the home…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a new device called VCFix for treating a broken bone in the spine (vertebral compression fracture). Ten adults with a single recent fracture will receive the implant to see if the procedure is safe and works as intended. The goal is to gather early data to plan a…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This trial tests a two-step treatment for chronic lower leg wounds that have not healed for over a month. First, a motorized waterjet cleans the wound, then a motion-based suction device applies negative pressure to promote healing. The study includes 50 adults with various types…

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study tests if a newer surgical plate placed on the front of the arm is as safe and effective as the standard method using two plates on the back. It involves 68 adults with a specific type of broken arm bone. The goal is to see which approach leads to better arm function an…

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This study tests whether stimulating the vagus nerve while doing rehabilitation exercises can help people with chronic spinal cord injury regain movement and sensation. Twenty participants who completed an earlier trial will receive active VNS paired with exercises targeting the …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study is checking how safe and effective Stryker's custom-made PEEK implants are for fixing bone and soft tissue problems in the skull and face. About 99 people who need these implants will be followed for up to 24 months after surgery. The main goal is to see how often infe…

This study tests whether custom-made positioning guides and titanium plates, designed from a patient's own CT scan, can improve the accuracy and stability of surgery for cheekbone (zygomatic) fractures. Eight adults needing surgery will receive the custom implants, and their resu…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This phase 3 trial tests whether adding a local injection of the antibiotic tobramycin to standard IV antibiotics can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because the wound may not get enough blood flow for IV antibiotics…

This study tests a device called AGN1 LOEP SV Kit for people with painful spinal fractures caused by osteoporosis. The device is injected into the broken vertebra to stabilize it. Researchers will track pain relief over 12 months in 100 participants aged 50 and older.

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study tests a technique called acute normovolemic hemodilution (ANH) in 2000 high-risk heart surgery patients. Before the heart-lung machine is used, doctors remove some blood and replace it with fluids. The goal is to see if this reduces the number of patients who need a bl…

This study tests whether a single 3D titanium miniplate can replace the standard two-plate method for fixing a broken jaw (mandibular angle fracture). Twenty male patients will be randomly assigned to receive either the 3D plate or the standard two plates. The main goal is to see…

This study compares two standard methods for treating severe traumatic brain injury in the ICU. One method monitors only brain pressure, while the other also tracks brain oxygen levels. About 1,094 patients will take part to see which approach leads to better recovery and surviva…

This study tests whether a repairing gel (Supraz) combined with a platelet-rich plasma-fibrin glue can eliminate odor and help heal chronic wounds that haven't improved with standard care. About 40 adults with a single wound lasting at least 3 months will receive either the new t…

This study is testing a bone graft implant called OsteoPearl in 25 adults aged 50 and older who have a spinal compression fracture. The implant is placed during a standard procedure to stabilize the fracture. Researchers will track pain and quality of life over 30 days to see if …

This study compares two types of artificial elbow joints used to replace a broken bone in the elbow that can't be fixed. About 90 patients will be randomly assigned to receive one of two implant designs. Researchers will track their elbow function, pain, and movement for two year…

This pilot study tests whether metformin, a common diabetes drug, can help older adults recover muscle and function after a hip fracture. Sixty people aged 60 and older will take either metformin or a placebo daily for 4 months after surgery. The main goal is to see if the study …

This study tests whether placing vancomycin powder directly into the wound during spine surgery can prevent infections in high-risk patients, such as those with spinal deformities or tumors. Half of the 76 adult participants will receive the powder, while the other half will not.…

This study is checking how well a new hip replacement part (the HYPE stem) works and lasts over 10 years. About 180 people with hip disease from arthritis or injury will get the implant. Doctors will use X-rays and surveys to see if the implant stays firmly in place and helps red…

This study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study tests two surgical ways to increase the amount of firm gum tissue around dental implants. One method uses a strip of the patient's own gum plus a collagen patch, while the other uses a larger piece of the patient's gum. The trial will measure how much gum tissue grows …

This study reviews the safety and performance of Stryker's Facial iD Universal Plate Configurator, a device used to fix facial fractures or during reconstructive surgery. Researchers will look at medical records of 726 patients who received the implant to see if unplanned revisio…

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions a…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study tests whether giving estrogen through a vein during kidney transplant surgery can reduce damage to the new kidney. It includes 30 women who need dialysis and are getting a kidney from a deceased donor. The goal is to see if estrogen helps the kidney work better right a…

This study tests whether a graft made from eggshell-derived nanohydroxyapatite, combined with a patient's own blood components, can preserve jawbone after a tooth extraction. Thirty-four adults with a hopeless back tooth will receive either this new graft or a standard animal-der…

This study looks at whether taking cocoa extract or a daily multivitamin can reduce falls and improve physical performance in older adults. Over 21,000 men and women aged 60 and older are participating. Researchers are tracking falls that require medical care and repeated falls t…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study compares two bone cements used to treat painful spinal fractures caused by osteoporosis. One cement includes a softener (V-Flex) to make it less rigid, while the other is standard cement (V-Steady). The goal is to see if the softer cement reduces the chance of new frac…

This study tests whether a mouthwash containing chlorhexidine and hyaluronic acid helps gums heal better after wisdom tooth removal. Fifty-four healthy adults who need wisdom tooth surgery will use the mouthwash, and doctors will check their healing over two weeks. The goal is to…

This study tests whether adding a blood flow restriction (BFR) cuff to standard physical therapy helps people recover better after wrist fracture surgery. The cuff is placed on the arm during low-intensity exercises to mimic the effects of high-intensity training. Researchers wil…

This study tests three ways emergency responders help children breathe: a bag-mask, a throat tube, or a breathing tube. It includes 3,000 children under 18 with cardiac arrest, severe injury, or breathing failure. The goal is to see which method leads to more days alive and out o…

This study is following 110 people who received a Tornier HRS shoulder replacement to see how well it improves pain and function. Participants have conditions like arthritis, fractures, or rotator cuff tears. The goal is to collect long-term safety and performance data for regula…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This study compares a standard rehab program to a foot-intensive rehab (FIRE) program in 150 adults aged 18-44 with chronic ankle instability. Participants do 2 supervised and 3 home sessions per week for 6 weeks. The goal is to see if FIRE reduces re-injury rates, improves stabi…

This study followed 413 people with hip arthritis who received a new type of hip replacement called the OXINIUM DH system. The goal was to see how well the implant worked and how safe it was over 10 years. Researchers checked pain, movement, and whether the implant stayed in plac…

This study is checking the long-term safety and performance of two hip implant devices (RingLoc Bipolar Acetabular Cup and Endo II Femoral Head) used in hip replacement surgery. Researchers will follow 116 patients who had their surgery at least eight years ago, tracking complica…

This early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…

This early-phase study tests whether combining noninvasive spinal cord stimulation with the drug buspirone can help people with severe spinal cord injury take steps overground. Fifteen participants who have been paralyzed for at least a year will undergo various training and meas…

This study compares a new temporary dressing called PermeaDerm with a standard one (Allograft) for people who need a skin graft after surgery or injury. About 40 participants will have the dressing applied to their wound, then a skin graft a few days later. Researchers will check…

This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use eith…

This study tests whether adding non-invasive ventilation (a breathing machine) or the drug Buspar to a special rowing exercise program can improve heart and lung fitness in people with high-level spinal cord injury. Seventy participants will exercise for 6 months while receiving …

This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, an…

This study tests a program called NeuroResource Facilitation for offenders with brain injury who are about to be released from prison. The program assigns a facilitator to help them access medical care, job training, and other support services. Researchers will track whether this…

This study looks at the safety and performance of a cemented hip stem (TrendHip®) in 119 people who had hip replacement surgery. It tracks pain, function, and quality of life for up to 5 years after surgery. The goal is to confirm the device works well in everyday use.

This study tests a new synthetic skin substitute called NovoSorb BTM for treating severe burns. About 150 adults with deep burns covering 3% to 60% of their body will receive either the new matrix or standard care. The goal is to see if the new material helps burns close complete…

This small study tests a noninvasive method called transcutaneous spinal cord stimulation (scTS) to help children aged 7-12 with chronic cervical spinal cord injury regain hand function. Researchers will find the best placement and strength of stimulation on the neck and lower ba…

This study looks at people with a single broken bone in the middle-to-lower back (thoracolumbar burst fracture) but no nerve damage. It compares two standard treatments: surgery and non-surgical care (like a brace). The goal is to see which approach leads to better daily function…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study looks at a metal plate and screw system used to fix certain types of broken upper arm bones. About 135 adults who need surgery for a fresh fracture or one that didn't heal with a cast will be followed for one year. The main goal is to see how often a second surgery is …

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study compares a special suction bandage (PICO) to standard wound cleaning for foot ulcers and wounds that have reopened after surgery. 300 adults with non-infected wounds are randomly assigned to either the suction device or usual care. The main goal is to see if the suctio…

This study tests whether custom-made 3D titanium plates are better than standard two-plate systems for fixing a specific type of jaw fracture. Eighteen adults with a broken jaw angle (non-infected, within two weeks of injury) will receive one of the two treatments. The main goal …

This study follows 102 people who received the aneXys hip replacement cup to see how safe and effective it is over 2 years. Researchers measure if the cup moves and track pain and function using standard scores. The goal is to confirm the device works well in everyday use.

This study looks at how well the ExploR Radial Head implant works over time for people who had elbow replacement surgery after an injury. Researchers will track about 93 patients to see how long the implant lasts and if any problems arise. The goal is to confirm the device is saf…

This study tests whether adding a daily supplement (vitamins D, K, C, magnesium, zinc, copper) to pulsed electromagnetic field therapy helps women aged 45-55 heal faster from a wrist fracture. Sixty women will either use the device alone or the device plus supplement for 30 days.…

This study tests a new surgical method that uses a tiny camera (endoscope) to repair broken facial bones through small, hidden cuts instead of large incisions. The goal is to see if this approach works as well as standard surgery while reducing scarring and nerve damage. Thirty a…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study followed 13 children and adults who had a permanent tooth knocked out and then put back in (replanted). The goal was to see how long the replanted teeth lasted and what problems occurred. Researchers also looked at how factors like time out of the mouth and storage met…

This study tests a new artificial disc implant (PerQdisc) placed during surgery for a herniated disc. The goal is to see if it is safe and helps reduce back and leg pain. About 50 adults with a single herniated disc in the lower back will take part. The implant is meant to replac…

This study tests whether a special fish skin graft can help deep burn wounds heal without needing as much skin taken from the patient's own body. About 65 adults with deep partial-thickness burns will receive both the fish skin graft and a standard skin graft on different burn ar…

This study follows 200 adults who receive the Shoulder iD™ implant to treat severe rotator cuff tears or shoulder arthritis. Researchers measure how well the shoulder works and how often the implant needs to be fixed or replaced over 10 years. Participants attend regular check-up…

This study looks at two ways to treat serious shoulder fractures in people aged 65 to 85: a reverse total shoulder replacement (surgery) or non-surgical care like a sling and physical therapy. The goal is to see which approach leads to better arm and shoulder function and quality…

This study was designed to test a new metal implant called the Artemis Proximal Femoral Nail for fixing a common type of hip fracture. The plan was to compare results from patients who received this implant to similar patients from the past who received other implants. However, t…

This study compares a high-tech, computer-controlled knee-ankle-foot brace (C-Brace) to traditional braces in 30 people with spinal cord injury. Participants will train with the device for up to 20 sessions and then use it at home for 3 months. The main goal is to see if the smar…

This study is testing a metal plate (the NuVasive ACP system) used during neck spine surgery to treat conditions like disc disease, stenosis, or fractures. About 75 adults will receive the plate and be followed for up to 24 months to see how safe it is and how well it helps with …

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This study tracks 100 adults who need a hip replacement to see how well the Avenir cemented hip stem works and holds up over time. Participants have conditions like arthritis, hip fractures, or hip damage from past surgeries. The main goal is to measure how long the implant lasts…

This study looks at how well two specific shoulder replacement parts work over time. It includes 146 adults who already had or will have shoulder replacement surgery. Researchers will check for problems and ask patients about their shoulder function for up to 10 years after surge…

This study looks at how well a special shoulder implant works for people who need a joint replacement due to arthritis, injury, or bone loss. Researchers will track 22 participants to see how long the implant lasts and if there are any problems. The goal is to make sure the impla…

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study looks at whether giving platelets (cells that help blood clot) to people with severe traumatic brain injuries who are on antiplatelet medications (blood thinners) can improve clotting and stop bleeding in the brain. About 225 adults with certain types of head bleeds wi…

This study is following 202 people who received a special hip liner during hip replacement surgery. The goal is to see how long the liner lasts and whether it causes any problems over time. Participants are adults aged 18 to 80 with conditions like arthritis or hip fractures. The…

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study looks at whether a strong antibiotic called meropenem (a carbapenem) works better than another antibiotic called piperacillin/tazobactam for treating sepsis in burn patients. Sepsis is a life-threatening infection that can happen after severe burns. The study will trac…

This study tests an implanted stimulator and sensor that helps people with cervical spinal cord injury regain hand and arm function. Ten participants will use the device to perform everyday tasks like grasping objects. The goal is to improve independence and quality of life.

This study tests whether a special lipid cream (EpiCeram) can prevent healed chronic wounds—like diabetic foot ulcers or pressure sores—from reopening. About 100 adults with recently healed wounds will apply either the cream or Vaseline for 3 months. Researchers will measure skin…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This study tests a surgical technique called retrograde elastic nailing with a pollar K-wire for children aged 3-15 with hard-to-heal wrist fractures. The goal is to see if this method improves bone alignment and reduces complications. Twenty children who failed closed reduction …

This early study tests if a dye called Lumitrace, given as a shot, can make the ureters (tubes from kidney to bladder) glow under a special blue light during minimally invasive belly surgery. About 10 adults having such surgery will get the dye, and surgeons will rate how well th…

This study tests a device called HITT that scans the eyes to detect subtle changes in eye movement and alignment that may occur after a mild traumatic brain injury (TBI). About 200 people aged 13 to 45 who recently experienced head trauma will have their eyes scanned, along with …

This study looks at whether a simple blood test can help doctors decide if a head CT scan is really needed after a mild head injury. Researchers will collect blood samples from 350 adults with mild head trauma and see if the test results match the need for imaging. The goal is to…

This study compares the standard X-ray with a bedside ultrasound to confirm that a dislocated shoulder has been successfully put back into place. Adults with an acute shoulder dislocation will receive both tests in the emergency department, allowing doctors to see if the ultrasou…

This study tests how accurately doctors, nurses, and technicians can diagnose ear barotrauma (pressure injury to the ear) using two different grading systems: the TEED score and the O'Neill Grading System (OGS). Thirty healthcare providers will grade 120 photos of eardrums to see…

This study compares a new device, cureVision cV, to an existing one (MolecuLight i:X) to see if it can accurately detect moderate to high levels of bacteria in wounds. About 100 adults with various wound types (like diabetic foot ulcers or surgical wounds) will be enrolled. The g…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see exactly which parts of a burn wound are dead or inflamed. Up to 100 burn patients will receive the dye and have their wounds imaged with a special camera before and during surgery. The…

This study compares an artificial intelligence (AI) algorithm's ability to detect broken bones on X-rays with that of doctors, including residents and specialists. About 500 X-rays from emergency patients with suspected fractures will be reviewed by both the AI and human readers.…

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study looks at ways to help teen drivers stay safe on the road. Car crashes are the top cause of death for teens. Over 2,200 teens and their parents will test new strategies to reduce accidents. The goal is to find clear methods that prevent crashes and save lives.

This trial tests whether a multicomponent exercise program—combining plyometric, strength, and core exercises—can improve athletic performance and reduce injuries in recreational runners. Participants, who run 20-100 km per week, will be randomly assigned to either this program o…

This study tests a program called PREVENT designed to reduce hip fractures in long-term care homes. The program uses a risk calculator based on residents' health records to identify those at high risk, then trains healthcare staff on the latest fracture prevention recommendations…

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This pilot study tests a culturally adapted fall prevention program for adults aged 60 and older living in urban Karachi, Pakistan. Participants take part in a 7-week group program covering strength and balance exercises, home safety, and medication awareness. The study aims to s…

Gun violence is the leading cause of death for children in the U.S. This study tests a video program called Rise Up! Against Violence for middle schoolers. High school students who have experienced gun violence made the videos to teach younger kids about the real-life consequence…

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study tests a program called ACTFAST that trains doctors and nurses at three children's trauma centers to talk with families about safe firearm storage. The goal is to help prevent gun injuries in kids. Researchers will survey parents, teens, and clinicians to see if the tra…

This study tests a program called ACTFAST in three trauma centers. The program screens injured patients for firearm access, offers brief counseling on safe storage, and connects them to community resources. Researchers will track whether the program increases safe storage practic…

This study tests whether a brief 10-20 minute motivational interview given to injured patients who drink heavily can reduce future harm. Researchers will track hospital readmissions, DUIs, and drinking behavior over 12 months in 830 adults. The goal is to see if a simple conversa…

This study tests a 3-month web-based education program for mothers of children aged 0-3. The program teaches how to prevent common home accidents like falls, burns, and poisoning. 140 mothers in Turkey will be randomly assigned to either the web program or usual care. Researchers…

This study compares three care models to prevent falls and fractures in older adults recovering from a broken bone in a skilled nursing facility. About 3,780 participants across 42 facilities will receive either medication reduction, bone health management, or both. The goal is t…

This study tests two physiotherapy approaches—manual therapy (joint mobilization) and proprioception (balance) exercises—against a placebo to see which best improves balance and prevents ankle sprains in young soccer players. Forty-five boys aged 11-13 who have played soccer for …

This study looks at whether the Nurse-Family Partnership program, where nurses visit first-time, low-income mothers during pregnancy and early childhood, can prevent preterm birth, low birth weight, and injuries in children. About 6,000 mothers in South Carolina are taking part. …

This study tests whether a new ankle brace changes how athletes run and cut. Researchers will compare five different bracing conditions. Participants will run on a treadmill, do shuttle runs, and fill out surveys about comfort and stability. The goal is to see if the brace is com…

This trial tests whether a special wound dressing called Suprathel can help partial-thickness burns heal without needing a skin graft. Adults with burns covering at least 2% of their body will receive either Suprathel or standard care. The study looks at how many people avoid gra…

This study looks at whether reusing walking boots is safe for people recovering from foot or ankle injuries. About 60 patients will be randomly assigned to get either a new boot or a cleaned, reused boot. The main goal is to see if reused boots cause more skin problems like blist…

This study tests a computer-based cognitive rehabilitation program designed to improve thinking skills, particularly time-based prospective memory—remembering to do things at a specific time—in people who have had a moderate-to-severe traumatic brain injury (TBI) at least a year …

This study tests whether transcutaneous spinal cord stimulation (TSCS) — a gentle electrical current applied through the skin — can help veterans with chronic spinal cord injury (SCI) better regulate blood pressure during exercise and cold exposure. Participants will receive both…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether placing a placental-based allograft called Amnioeffect on the surgical wound improves scar appearance, pain, and swallowing after thyroid or parathyroid surgery. About 334 adults will be enrolled, with half receiving the graft and half getting standard ca…

This trial tests whether a smartphone-based virtual reality tool (VR-PAT) can reduce pain during at-home burn dressing changes in children aged 6 to 17. Half of the 200 participants will use VR-PAT during their daily dressing changes, while the other half will not. Researchers wi…

This study tests whether showing 3D hologram videos during burn dressing changes can reduce pain, anxiety, and fear in patients. 70 adults will be randomly assigned to either watch a hologram or receive standard care. The hologram projects interactive images into the air without …

This study tests whether ketamine or lidocaine infusions can better manage pain from multiple broken ribs, reducing the need for opioids. About 74 adults with at least three broken ribs will receive one of the two medications for 72 hours. The goal is to improve breathing, reduce…

This trial tests whether a personalized form of transcranial magnetic stimulation (TMS) can ease persistent headaches and other symptoms after a mild traumatic brain injury. Researchers will use each participant's brain scan to target the specific networks linked to their most bo…

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The training combines exercises to recognize emotions in faces and voices with attention training, since paying attention is key to understanding emotions in daily life…

This study tests whether 36 sessions of a computer-based brain training program, called PATH neurotraining, followed by digit memory exercises, can improve working memory, processing speed, and attention in people who have had a mild traumatic brain injury (concussion). The train…

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce pain and anxiety and improve quality of life for burn patients during dressing changes. About 96 adults with second-degree burns will be randomly assigned to receive the stimulation before o…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests whether a 6-week pulmonary rehabilitation program—combining breathing exercises and arm workouts—can improve lung function and physical ability in adults who had burns on their arms. Sixty-four participants will be randomly assigned to either the rehab program or…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether a saphenous nerve block can safely reduce pain after surgery for a tibial plateau fracture. Typically, nerve blocks are avoided in these fractures because numbness might mask compartment syndrome, a serious complication. The saphenous nerve block targets …

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This study tests whether a cream made from human fat can help skin graft donor sites heal faster and form better scars. Thirty adults getting skin grafts will have two donor sites: one treated with the fat extract and the other with standard care. Researchers will compare healing…

This study compares virtual reality exercises to standard physical therapy for improving walking and balance in adults aged 60 and older. Thirty-six participants will either use a VR headset to play movement games or do traditional exercises like tandem walking. Researchers will …

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This study tests whether an implanted spinal cord stimulator can reduce chronic pain and improve rehabilitation outcomes in people with thoracic spinal cord injury. Twenty-five participants will either have the device turned on or off for three months, while both groups continue …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study compares two types of nerve blocks (PENG and FICB) to see which provides better pain relief for people with hip fractures in the emergency department. About 50 adults with a broken hip will receive one of the two blocks, and researchers will measure their pain scores a…

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This study tests whether using virtual reality and action observation therapy during the time a wrist or hand is in a cast can improve recovery. Participants watch first-person videos of hand movements through a VR headset and then practice those movements. The goal is to prevent…

This study compares two ways to manage pain before spinal anesthesia for hip fracture surgery: a fascia iliaca block (a numbing injection near the hip) versus intravenous nalbuphine (a painkiller given through a vein). Researchers will measure pain scores and how well patients ca…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests whether high doses of branched chain amino acids (BCAAs), a type of supplement, can help people aged 11 to 23 recover from a concussion more quickly. Participants receive either a BCAA drink or a placebo for 28 days. The main goal is to see if more people in the …

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests whether a structured physical therapy program (STAT) helps people with severe burns recover better than standard therapy. About 166 adults aged 18-65 with burns covering at least 15% of their body will take part at seven burn centers. The main goal is to see if t…

This study tests three types of wave therapies—focused shockwave, radial pressure waves, and electromagnetic therapy—to treat leg injuries like muscle, cartilage, and bone damage. Researchers at Mayo Clinic will enroll 200 adults to see if these treatments reduce pain and improve…

This study tests whether a nerve block called erector spinae plane block can reduce the amount of morphine needed for pain after spinal fracture surgery. About 86 adults having minimally invasive spine surgery will be randomly assigned to receive either the nerve block or a place…

This study tests whether a hormone called pregnenolone can improve mental health, thinking, and pain in veterans who had a mild traumatic brain injury (TBI) while serving after 9/11. About 108 veterans will take either pregnenolone or a placebo daily for 8 weeks. Researchers will…

This pilot study tests whether robot-assisted gait training can improve walking in people with lower limb burns and fractures. Five participants will receive 30 minutes of robot training plus 30 minutes of conventional therapy daily for 8 weeks. The goal is to see if this combina…

This early-stage study tests whether a smartphone app and remote training can help military members and active young adults recover from a mild concussion. The goal is to improve symptoms and lower the risk of getting hurt again. About 88 people will participate.

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study aimed to compare two ways to manage pain from broken ribs: a continuous IV drip of lidocaine versus a nerve block called an erector spinae plane (ESP) block. The goal was to see which method reduces pain and improves breathing better. However, the study was withdrawn b…

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study tests whether walking with a robotic exoskeleton three times a week for 12 weeks can reduce nerve pain in people with spinal cord injury. Forty adults with traumatic spinal injury and persistent nerve pain will be randomly assigned to either robotic walking or a relaxa…

This study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …

This study looks at why some people get persistent headaches after a mild concussion and tests a new treatment called repetitive transcranial magnetic stimulation (rTMS). Researchers will measure headache days and blood markers in 62 adults who had a mild brain injury 2-4 months …

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study looks at whether a special pain injection given around the knee during surgery can lower pain for people with a tibial plateau fracture (a break in the top of the shinbone). About 150 adults with this type of fracture will receive the injection, and their pain scores w…

This study tests whether remote monitoring through a secure app can safely replace in-person follow-up visits after wrist fracture surgery. Researchers will compare recovery, satisfaction, and complication rates between 160 adults who use virtual check-ins and those who attend st…

This study compares two ways to numb the wrist during a broken bone repair: a hematoma block (injecting numbing medicine into the fracture site) and a Bier block (using a tourniquet and IV numbing medicine). 500 adults with a broken wrist will be enrolled to see which method prov…

This study looks at whether progressive muscle relaxation exercises can improve sleep, reduce anxiety, and help body image in people with burn injuries. About 100 adults with second-degree burns will either do these exercises twice daily for a week or receive standard care. The g…

This trial tests whether a 10-week online health program called DRIV can help adults with long-term spinal cord injury adopt healthier habits and feel better. Participants attend weekly video group sessions covering exercise, nutrition, stress, and goal-setting. Researchers compa…

This study tests if a special light treatment, called photobiomodulation therapy (PBMT), can improve how scars look and feel after a facial wound is stitched up. About 36 people with facial cuts will receive either the light therapy or a fake treatment after their stitches are re…

This study compares two types of injections—platelet-poor plasma and corticosteroids—for treating thigh muscle injuries in athletes aged 15-30. The main goal is to see which treatment helps athletes return to sports faster and with less pain. Participants will be randomly assigne…

This study tests whether a 3-week outpatient rehab program can reduce long-lasting symptoms of traumatic brain injury (TBI) and related conditions like PTSD and depression in 416 veterans and first responders. Participants will complete surveys, and some will also give blood samp…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This study looks at whether wearing a splint and going to formal physical therapy are necessary after surgery for a broken wrist. About 230 adults with a specific type of wrist fracture will be followed to see if early movement (no splint) leads to better outcomes and lower costs…

This study compares two sedative drugs (midazolam and dexmedetomidine) given as nasal sprays to 32 people having surgery for a broken lower jaw. The goal is to see which drug provides better sedation and how they affect heart rate and blood pressure. Participants are healthy adul…

This study tests a type of talk therapy called graded exposure therapy for people who have had a concussion and are still having symptoms. The therapy, delivered by a psychologist over 12 video sessions, helps people gradually face activities they have been avoiding due to fear o…

This study compares two surgical techniques for repairing a broken hip (femoral neck fracture) in adults over 50. One is the standard direct lateral approach, and the other is a newer muscle-sparing method called SPAIRE. Researchers want to see which approach leads to better hip …

This study looks at whether using a powered exoskeleton to walk can improve quality of life for people with spinal cord injury. Eighteen participants will either use the device at home or in a clinic over 24 months. Researchers will measure changes in well-being and compare costs…

This study is testing two methods of giving pain medicine through a small tube placed near a nerve after surgery. One method gives a steady, low-dose drip, while the other gives larger doses at set times. The goal is to see which method provides better pain control and lasts long…

This early-phase trial compares two drugs—dexamethasone and dexmedetomidine—added to standard spinal anesthesia for pelvic fracture surgery. Sixty adults will be split into two groups to see which combination provides longer pain relief and better recovery. The goal is to find a …

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This study tests if microneedling, a technique that creates tiny skin channels, followed by cortisone cream can improve burn scars. It aims to make scars softer, thinner, and less red. The trial includes 36 adults with at least two burn scars.

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a device that stimulates the vagus nerve during arm rehabilitation exercises to see if it helps people with spinal cord injuries regain upper limb function. Twenty adults with chronic cervical spinal cord injury will receive either active or placebo stimulation d…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study planned to test whether giving ear acupuncture during wrist fracture surgery could lower the amount of opioid painkillers patients need afterward. It was designed for adults aged 18–64 having a specific type of wrist repair. However, the trial was withdrawn before enro…

This study planned to test whether adding ear acupuncture to standard pain management could reduce opioid use after surgery for lower leg fractures. It was designed for adults aged 18–64 undergoing ankle or foot fracture repair. However, the trial was withdrawn before enrolling a…

This study tests whether an 8-week group exercise class done over video can improve psychological and social well-being in people with spinal cord injury. The class is tailored for wheelchair users and co-led by someone with lived experience. Researchers will measure changes in m…

This study tests a program called BreeZe that helps burn survivors take charge of their recovery. The goal is to improve quality of life by teaching skills like goal-setting and problem-solving. About 146 adults from three burn centers in the Netherlands will take part. Researche…

This study compares two recovery approaches after wrist fracture surgery: moving the wrist right away versus wearing a cast for two weeks. Researchers want to see which method helps patients return to work sooner and improves wrist function. About 240 adults aged 18-65 with a bro…

This study looks at whether a program called LearningRx can improve thinking skills, daily life function, and work confidence in adults who have had a traumatic or acquired brain injury, including from COVID-19. About 30 participants will complete cognitive exercises and be teste…

This early study tests whether combining a spinal cord stimulator with the drug buspirone can improve arm and hand movement in people with cervical spinal cord injury. Twelve participants will receive both the device and the drug, and their motor function will be formally assesse…

This study tests a surgical procedure called partial wrist denervation, done at the same time as standard fracture repair, to see if it reduces the chance of long-term wrist pain. Researchers are enrolling 56 adults with severe, shattered wrist fractures. The main goal is to meas…

This pilot study tests whether adding blood flow restriction therapy to standard physical therapy helps elderly patients (65 and older) recover muscle strength and size after hip fracture surgery. Twenty participants will have their thigh and leg measurements, muscle strength, pa…

This study tests whether a wearable robot suit can help people aged 65 and older recover leg function after hip fracture surgery. Participants will either do standard rehab or use the robot suit during therapy. The goal is to see if the robot improves walking, balance, and pain b…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study looks at whether floating in a special tank that reduces outside stimulation can help people with posttraumatic stress disorder (PTSD). About 30 adults with PTSD will take part. Researchers will measure changes in PTSD symptoms, stress, mood, and pain before and after …

This study looks at two different nerve block techniques used alongside low-dose spinal anesthesia for hip fracture surgery in elderly patients. The goal is to see which method better prevents severe drops in blood pressure during surgery and improves pain control afterward. Abou…

This study looks at two different nerve-block methods to control pain after hip surgery. One group gets a standard block that numbs the hip joint, while the other gets an extra block for the thigh skin. The goal is to see which method reduces pain, lowers the need for pain medici…

This study tests whether a gentle electrical current (TENS) applied to the lower back can reduce muscle stiffness and improve movement in people with spinal cord injuries. Forty adults with injuries between the neck and mid-back will either receive TENS for two months or wait two…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This study tests a chatbot called 'Wrist Health' that helps elderly patients (ages 60-90) recover from wrist fractures at home. The chatbot provides exercise instructions, education, and reminders, and tracks how often patients use it. Researchers want to see if using the chatbot…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study tests two additional therapies for people recovering from a broken wrist (distal radius fracture) treated with surgery. One therapy uses gentle manual movements (Mulligan mobilisation), and the other uses mental imagery exercises (graded motor imagery) to retrain the b…

This study tests whether a special skin protectant spray (3M Cavilon Advanced) can heal partial-thickness wounds caused by moisture (like from incontinence or stoma leaks) faster and with less pain than usual hospital wound care. About 36 adults in hospitals will be randomly assi…

This study compares three types of local anesthesia for people with a broken wrist who need a fracture reduction in the emergency room. It aims to find which method—a nerve block, a hematoma block, or both—provides the best pain relief. About 105 adults will take part, and their …

This study tests whether adding suzetrigine to standard pain treatments helps adults with multiple broken ribs feel less pain and use fewer opioids. About 80 people will be randomly assigned to get either suzetrigine or a placebo alongside usual care. The goal is to improve breat…

This pilot study aimed to test whether a virtual reality (VR) cooking simulation could improve arm movement and daily function in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdr…

This pilot study tests a custom-made mouthpiece created with 3D scanning and printing for people whose mouths became tight after burn scars. Ten participants will wear the mouthpiece all day except during meals for two months. Researchers will measure if it improves mouth opening…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study looks at whether starting weight bearing and active knee exercises soon after surgery for a tibial plateau fracture (a type of knee break) helps reduce pain, improve knee movement, and support bone healing. About 28 adults aged 18 to 50 who had a specific type of fract…

This early-phase trial aimed to see if a nose spray sedative (dexmedetomidine) could safely and effectively sedate children aged 2–18 with a broken forearm, compared to the standard IV ketamine. The study was withdrawn before any participants were enrolled, so no data was collect…

This study looks at whether wearing a cast for 4 weeks instead of 6 weeks helps adults with a broken wrist recover just as well. About 80 adults aged 18 to 50 with a specific type of wrist fracture will be randomly assigned to either 4 or 6 weeks of casting. The main goal is to s…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a special light box each morning, and researchers track changes in sleep quality, mood, thinking, and blood markers. The goal is to find…

This study aimed to see if adding blood flow restriction (BFR) therapy to standard physical therapy improves recovery after surgery for a tibial plateau fracture. It planned to enroll adults who had that surgery and measure knee function, muscle size, and movement over one year. …

This study tests whether a trauma-informed care plan (TICP) placed in the electronic medical record helps healthcare teams better care for patients with trauma and complex needs. About 200 patients and their clinicians will use the plan, and researchers will measure how acceptabl…

This study looks at whether applying heat and giving abdominal massage soon after hip fracture surgery can improve bowel function and mental well-being. About 75 adults who had hip surgery and haven't had a bowel movement yet will receive these treatments twice a day for three da…

This study tests a new type of magnetic brain stimulation in 15 adults who have had a mild traumatic brain injury and still have symptoms like headaches or trouble thinking. Participants get 30 short treatment sessions and detailed MRI scans before and after. The goal is to see i…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study aimed to see if giving a nerve block before and after hip fracture surgery could reduce pain, confusion, and hospital stays in patients 65 and older. The trial was withdrawn before any participants were enrolled, so no conclusions can be drawn.

This study tests whether taking a person's own fat and injecting it into burn scars on the arms can improve scar appearance and movement better than standard treatments like steroid shots or surgery. Forty adults with burn scars will be randomly assigned to fat grafting or usual …

This study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…

This study looks at whether adding acupuncture to usual care (painkillers and physical therapy) can improve pain and mobility in people recovering from hip fracture surgery. About 90 adults aged 40–99 will be randomly assigned to receive either standard care alone or standard car…

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study follows 300 people who had a traumatic brain injury (TBI) for at least two years after their injury. Researchers want to see how their recovery changes over time and test a blood marker that may show brain damage. The goal is to better understand the long-term effects …

This study looks at whether a special computer tool can help doctors better care for children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers wil…

This trial tests whether a treadmill that automatically adjusts its speed to the walker can help people with weakness on one side of the body take more even steps. Participants with hemiparesis from a stroke or traumatic brain injury will walk on both a self-pacing and a fixed-pa…

This study follows breast cancer patients who have had curative surgery and are receiving hypofractionated radiation therapy—shorter treatment courses lasting one to three weeks. Researchers will track changes in breast skin, fibrosis, cosmetic appearance, and patient-reported ou…

This pilot study explores whether targeted visual attention training can improve cognitive processing in older veterans, particularly those with a history of mild traumatic brain injury (mTBI). Researchers will use EEG to measure brain wave activity during attention tasks, compar…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study tests a 12-session teletherapy program called ICARE for people with traumatic brain injury (TBI) and their care partners. The program teaches emotion recognition from facial expressions and empathy skills through role-playing. Researchers want to see if it's practical …

This study looks at whether offering free legal help to people recovering from violent injuries like gunshot wounds can lower stress and improve their health. Researchers will work with 500 patients at a trauma center to address problems like housing or money issues that often le…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…

This study tests whether a virtual reality brain-machine interface can help people with spinal cord injury regain function. Participants imagine moving their legs while wearing an EEG cap and VR headset, receiving sensory feedback. The goal is to understand how the brain's commun…

This pilot study is testing whether a specialized blood test called thromboelastography (TEG) can better evaluate clotting problems in people with severe burns. Researchers will track clotting patterns over the first four weeks after injury and see if they relate to burn size or …

This pilot study at Johns Hopkins will enroll 24 older adults having hip fracture surgery with bone cement. It compares general anesthesia to epidural (neuraxial) anesthesia to see which one lowers the risk of bone cement implantation syndrome—a serious complication that can caus…

This study looks at whether using a laser followed by a gel containing doxycycline (NanoDOX) can help medicine reach deeper into the skin and improve wound healing. About 12 healthy adults will receive the laser treatment and gel on small skin areas, and then have biopsies to mea…

This study explores new ways to improve patient education and care for adults who visit the emergency department with a mild traumatic brain injury or concussion. Researchers are testing different strategies to help clinicians provide clearer discharge instructions and follow-up …

This pilot study explores whether it is safe and practical to allow body temperature to rise to 39.5°C (permissive hyperthermia) in critically ill patients with severe brain injury, instead of aggressively treating fever. Twenty patients on ventilators with brain monitoring will …

This study develops and tests an artificial intelligence-based tool to predict major heart complications—such as heart attack, heart failure, or dangerous heart rhythms—in adults aged 60 and older after hip fracture surgery. Researchers will analyze data from 600 patients across …

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study follows about 420 people aged 65 and older who have a certain type of pelvic fracture. Researchers will collect information on their health, treatment, and recovery for up to one year. The goal is to better understand how these fractures affect daily life and mobility.

This study follows children and adolescents who experienced trauma to see how many still have PTSD or Complex PTSD two years later. Researchers will also look at factors like symptom severity, resilience, sleep, and anxiety that may influence recovery. The goal is to better under…

This study looks at how well and how safe Global D implants work for people who need surgery on their jaw or face after an injury. About 102 patients aged 11 and older will take part. The main goal is to see how well the jaw works 6 months after surgery using a simple questionnai…

This study tracks 750 teens aged 13-18 with mild concussions to see if changes in their saliva can predict how long symptoms last. Researchers will check for persistent symptoms 30 days after injury. The goal is to find biological markers that help doctors personalize recovery pl…

This study follows about 80 adults who receive the EasyMove total ankle prosthesis for severe ankle arthritis caused by injury, wear-and-tear, or rheumatoid arthritis. Researchers will monitor how often the implant loosens and needs revision, as well as pain, mobility, and functi…

This study explores how low-level laser therapy (LLLT) affects skin stiffness and thickness. Researchers will use a special imaging system to track tiny skin movements in 20 healthy adults. The goal is to find the best laser settings for future wound healing treatments.

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study follows 50 adults who had surgery for a broken shinbone to see if changes in the kneecap tendon's stiffness relate to knee pain. Researchers use a special ultrasound before and up to 6 months after surgery. The goal is to better understand why some people develop front…

This study was designed to compare two procedures—vertebroplasty and kyphoplasty—for treating spinal fractures caused by trauma. Researchers planned to measure how much bone cement was injected and how well the spine's shape and function were restored. However, the study was with…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part.

This study was designed to observe how patients with acute brain injury are taken off mechanical ventilation (breathing machines) in the ICU. It planned to include adults with brain injury who needed a ventilator for at least 24 hours, but the study was withdrawn before enrolling…

This study interviews 120 people—patients, relatives, and healthcare staff—to better understand what 'person-centered' means in rehabilitation. Researchers will use these insights to develop a tool that measures how well rehab services focus on individual needs. The goal is to im…

This study explores whether micro-Doppler radar, a type of motion-sensing technology, can tell if someone has had ACL knee surgery just by watching how they move. Researchers will compare movement patterns from 181 adults—some with past ACL repairs and some without—while they do …

This study looks at how having your arm in a cast or splint after an injury changes your brain activity and recovery. About 30 adults with wrist or hand injuries will have their brain waves measured with a safe, painless EEG test at three points: when the cast goes on, when it co…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study tests whether an app that helps patients and doctors make decisions together can lower the number of CT scans for people with minor head injuries. About 370 adults aged 18-65 who are at low risk for serious brain injury will use the app in the emergency department. The…

This study looks at 200 older adults (65+) who had hip fracture surgery. Researchers compared two common rating systems—the ASA score and the Clinical Frailty Scale—to see which better predicts whether a patient will need intensive care after surgery. The goal is to help doctors …

This study looks back at medical records of 233 older adults (65+) who had hip fracture surgery. Researchers want to see if certain blood test results, taken before and after surgery, can help predict who is at higher risk of dying within 30 days or needing a longer stay in the i…

This study looks at how different levels of traumatic brain injury (TBI) affect children's thinking, balance, and ability to do everyday tasks. Researchers will test 48 children aged 8 to 12 with mild to moderate TBI using standard assessments. The goal is to understand the links…

This registry will follow about 300 adults with orbital blow-out fractures to see how different treatments affect double vision and eye position over 6 months. Patients may receive surgery or non-surgical care as part of routine practice. The goal is to collect real-world data to…

This study looks at whether low blood pressure during major noncardiac surgery harms organs like the heart and kidneys. Researchers are using a non-invasive brain monitor to see if a personalized blood pressure target can be set. 650 patients at cardiovascular risk are being obse…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study checks how well a commercially available nail system works for fixing broken upper arm bones. 100 adults who need surgery for a humerus fracture will be followed for 12 months to see if the bone heals enough for normal activities. The goal is to confirm the device is s…

This study aimed to see if using real-time ultrasound during a thoracic epidural block makes the procedure more reliable. It was designed for adults with chest or abdominal pain or rib fractures. The study was withdrawn before enrolling any participants, so no results are availab…

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This study tests a new, low-cost device that creates controlled slips while people with incomplete spinal cord injuries walk on it. The goal is to measure how their balance changes, both standing still and moving. Ten participants who can walk without aids will be observed to bet…

Many pregnant women have experienced trauma, which can make prenatal care stressful and increase health risks. This study will create and test a toolkit to train obstetric providers in trauma-informed care, including screening tools and modified procedures. Researchers will work …

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study was designed to test a program that helps caregivers of people with traumatic brain injury improve their problem-solving skills. It planned to enroll adults aged 19 and older, but was withdrawn before any participants joined, so no results are available.

This study tests a tool that helps patients with lung cancer or lung metastases work with their doctor to choose the right radiation dose. The tool is designed for tumors very close to the chest wall. The goal is to see if using this tool leads to better shared decision-making an…

This study is a registry that collects medical records, quality-of-life questionnaires, and tissue samples from 900 people with spine tumors or other spine disorders. The goal is to learn more about these conditions to guide better treatment in the future. Participants must be be…

This study is creating a computer model to predict hamstring injuries in male football and handball players. Researchers will measure athletes' flexibility, strength, and other factors before the season, then track who gets injured. The goal is to find patterns that could help pr…

This study compares two surgical techniques (posterior SPAIRE and anterior approach) for treating broken hips in people aged 70–90. Researchers will measure recovery, muscle damage, and bone density changes in 210 participants. The goal is to see if one approach leads to better o…

This study follows 70 adults aged 65 and older admitted to the hospital with an orthopedic injury. Researchers measure muscle strength, mobility, and thinking skills shortly after admission, again at day 7 or discharge, and 4-6 weeks after leaving the hospital. They also intervie…

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This study looks at the medical records of over 550,000 athletes to understand how sports medicine services are used and how effective they are. The goal is to find ways to improve care and outcomes for people with sports injuries. No new treatments are being tested; instead, res…

This observational study looks at 300 adults with severe traumatic brain injury to see how low brain oxygen levels affect certain proteins in the blood, known as biomarkers. Researchers will measure these proteins to better understand brain damage and recovery. The study does not…

This study follows 113 adults with arm stiffness from brain injuries who are receiving botulinum toxin injections in routine care. Researchers measure how the treatment affects the burden on caregivers, the patient's disability, and other health factors over time. The goal is to …

This study looks at whether a computer model can predict heart injury after major orthopedic surgery in patients 65 and older. Researchers will combine blood tests, frailty scores, and other health data to build a machine learning tool. The goal is to help doctors spot high-risk …

This study tests an 8-week online group program called Living Longer and Stronger with SCI, designed to help people with spinal cord injury improve their physical, mental, and social health as they age. Participants set health goals and make weekly action plans with support from …

This study tests whether a drug called racecadotril can reduce fluid leakage in skin blisters, as a model for what happens in the lungs during Acute Respiratory Distress Syndrome (ARDS). ARDS is a severe lung injury with no effective drug treatments, where patients' lungs fill wi…

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study compares two recovery plans for people who had surgery for a specific type of knee fracture (unicondylar tibial plateau fracture). One group will start putting weight on their leg after 6 weeks, while the other follows the standard 10-week wait. Researchers will measur…

This study looks at how the body's inflammatory response after a specific type of knee fracture might be linked to developing arthritis later. Researchers will measure inflammatory markers in the joint fluid and blood of 60 adults with a tibial plateau fracture. They will also us…

This study compares genetic differences and muscle gene activity in people who develop acute compartment syndrome after a leg fracture versus those who do not. Researchers will measure a protein called myostatin in muscle tissue. The goal is to better understand why some people g…

This study looks at how vitamin D and vitamin K interact to affect bone density and fracture risk in older adults. Researchers are analyzing data from over 25,000 participants who took vitamin D and omega-3 supplements or placebos. The goal is to see if people with low vitamin K …

This study looks for biological markers in the body that could warn athletes about potential injuries before they happen. Researchers will use advanced technology to analyze samples from 60 athletes aged 12-30 who have had a recent sports injury. The goal is to find patterns that…

This study is working to create a prediction model specifically for children with moderate to severe traumatic brain injury (TBI). Currently, doctors use models designed for adults, which may not be accurate for kids. Researchers will analyze data from 2000 children to develop a …

This study tests whether giving patients with hand problems like carpal tunnel syndrome or trigger finger a decision aid—a booklet with clear information about their condition and treatment options—helps them feel more satisfied and less conflicted about their choices. About 126 …

This study follows 250 former NFL players and healthy volunteers aged 50-70 over 5 years. Researchers use brain scans, blood tests, and thinking/memory assessments to understand how concussions and repeated head impacts affect long-term brain health. The goal is to gather informa…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study follows about 190,000 Korean radiation workers to see if low-dose radiation exposure over time increases the risk of cancer and other diseases. Researchers will link national health records to track health outcomes. The goal is to better understand the long-term effect…

This study looks back at 300 patients who had a hip replacement after a cancer-weakened bone broke. Researchers want to see how well patients walk, their pain levels, and how long they live compared to patients from decades ago. The goal is to find what helps people walk again af…

This study tests a new way to measure how children move their arms using a special camera system that tracks reflective markers placed on the skin. Researchers will check if the method is reliable and easy to use in both healthy children and those with arm movement problems. The …

This study follows 118 adults who received a shoulder replacement using the Tornier Perform® Humeral System after a fracture or related joint damage. Researchers will collect data on pain, function, and safety over 10 years. The goal is to monitor real-world performance, not to t…

This study looks back at the medical records of 176 adults who came to a major trauma centre with injuries from bouldering, a type of rock climbing without ropes. The goal is to understand what kinds of injuries happen most often. No new treatments are being tested; instead, the …

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study looks at whether using sunscreen on a healing surgical scar improves how it looks. Fifty adults who had skin cancer surgery will have half of their scar treated with sunscreen and the other half left alone. After three months, doctors will compare the two sides to see …

This study compares three different therapy approaches to help people with cervical spinal cord injury improve arm, hand, and trunk control. Ninety-nine participants will complete 40 therapy sessions over 8 weeks, with follow-up at 12 weeks. The goal is to find which method works…

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This pilot study tests whether stitches or staples are better for closing surgical wounds after fixing broken leg bones. About 50 adults with certain leg fractures will be randomly assigned to one closure method. The main goal is to see if such a study is practical, not to prove …

This study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…

This study uses repeated MRI scans to track brain injury and growth in very preterm babies (born before 33 weeks) during their NICU stay. Researchers will also test a program called SENSE-plus, which involves daily gentle sensory activities like touch and sound, to see if it help…

This study aimed to find out which drug combinations are most commonly used when trauma patients need a breathing tube in the emergency department. Researchers planned to review medical records from several Texas trauma centers to see how different drug regimens affect patient ou…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …

This study looks back at the records of 417 adults with severe injuries (polytrauma) who were treated in the intensive care unit between 2020 and 2025. The goal is to describe their care, how long they stayed, and their survival. No new treatment is being tested; instead, researc…

This study looks back at medical records of 146 adults with stable spine fractures caused by falls or accidents. It compares three treatments: wearing a brace, a minimally invasive bone cement procedure, or spinal fusion surgery. The goal is to see which option leads to the best …

This study looks at whether non-invasive spinal cord stimulation, combined with breathing, arm, or trunk training, can improve lung and breathing muscle function in people with spinal cord injuries. 36 adults with injuries at or above the T5 level are participating. The goal is t…

This study aimed to create a self-management program to help veterans with AIS D spinal cord injury improve their well-being. It was designed for veterans who have some movement and sensation but often struggle with emotional and social challenges. However, the study was withdraw…

This study follows about 1500 adults with hip, shin, ankle, upper arm, or wrist fractures for up to one year. Researchers collect information on healing, patient-reported symptoms, and activity patterns using questionnaires and wearable sensors. The goal is to understand recovery…

This study aimed to find out if removing the nail plate helps people with nailbed injuries heal better. It was planned by Stanford University but was withdrawn before any participants were enrolled. No data or results are available from this trial.

This study looks at whether a simple ultrasound of the brain's blood flow can safely identify mild traumatic brain injury patients who can go home right away instead of staying in the hospital for observation. About 550 adults with mild head injuries will be randomly assigned to …

This study was designed to test whether a mobile app with personalized feedback and peer coaching could help young adults aged 18-29 who drink heavily and have experienced interpersonal trauma. Participants would have been randomly assigned to the enhanced app or a standard versi…

This study follows 50 adults with incomplete cervical spinal cord injuries to see how well certain tests capture their recovery over 6 months. Researchers will track things like movement, sensation, and balance to find the best ways to measure improvement. The goal is to make fut…

This study looks at whether ultrasound can accurately measure stomach contents in children with traumatic injuries who need emergency surgery. Researchers will compare ultrasound estimates with actual stomach fluid drained after intubation. The goal is to better predict aspiratio…

This study compares two treadmill tests—the Buffalo Concussion Treadmill Test and a modified dynamic exertion test—in teens aged 14-17 who had a sport-related concussion within the past 14 days. The goal is to see which test better measures symptoms like headache and dizziness, a…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study looks at 37 children with acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers want to see if measuring certain inflammation markers in saliva works as well as measuring them in fluid from the lungs. If saliva works, it could lead to a …

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study asks over 2,300 people with various joint conditions (like arthritis, fractures, and hip problems) to fill out surveys about their treatment preferences. Researchers want to learn how factors like pain, recovery time, cost, and surgery versus non-surgery affect patient…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

This study from Mayo Clinic will follow 4,000 athletes aged 12-30 to find better ways to diagnose concussions on the spot and set safe return-to-play rules. Researchers will also test if neck and vision training can help prevent brain injuries. The goal is to use simple tests and…

This study tests a new workshop designed to help caregivers in residential facilities use everyday interactions to build trusting, healing relationships with children who have experienced trauma. About 300 caregivers and children aged 8 and older will participate. The goal is to …

This study tests a training program for occupational therapists who work with adults who have had a brain injury. The goal is to help therapists better spot and treat anxiety and depression in their patients. Twenty therapists will take part, and researchers will see if they star…

This study looks at whether patients with surgically treated leg, pelvis, or hip socket fractures can safely start walking right away instead of waiting 6-12 weeks. About 100 adults will be randomly assigned to immediate weightbearing or delayed weightbearing. The goal is to see …

This study looks at dental and jaw problems in children who had proton beam therapy for head and neck cancer. Researchers will survey survivors and review dental records to see how often these side effects occur and how they relate to radiation dose. The goal is to gather informa…

This study looks at whether people can go home the same day after surgery for a broken wrist, instead of staying in the hospital overnight. Researchers will compare recovery, function, and patient satisfaction between the two groups. The goal is to see if same-day discharge is a …

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study follows 52 elite junior ice hockey players over a season to understand how head impacts affect the brain and body. Players wear helmet sensors to record impacts, plus heart rate monitors and cognitive tests to detect subtle changes. The goal is to improve concussion de…

This study aimed to see if custom carbon fiber braces could reduce forces on the ankle joint after a fracture, potentially lowering the risk of arthritis. It planned to enroll adults with healed ankle fractures and test different brace designs. However, the study was withdrawn be…

This study was designed to test whether a special checklist bundle (SCOPE-E) could help doctors who perform colonoscopy avoid work-related injuries. The trial planned to enroll endoscopists at multiple centers and measure their posture during procedures using an AI program. Howev…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study follows 400 Swedish elite football players (academy and professional) for up to 5 years to understand how physical fitness, training load, and other factors relate to injury risk and success. Researchers will measure endurance, strength, speed, and neuromuscular contro…

This laboratory study looks at how freezing and thawing affects human cells. Researchers will test different freezing methods on cell samples to see which keeps the most cells alive and healthy. The goal is to improve cell storage for future medical use. No human participants are…

This study looks at two methods for setting the pressure of a tourniquet (a tight band that stops blood flow) during surgery for a broken wrist. The goal is to see which method gives surgeons a clearer view, causes less pain, and leads to fewer complications. About 140 adults hav…

This study was designed to observe and compare the quality of burn scars in people treated with two different skin substitutes—Integra and NovoSorb BTM—12 to 36 months after their final skin graft. Researchers planned to review medical records, use non-invasive scar measurements,…

This study compares how well different tourniquet models block blood flow when placed on the arm, forearm, leg, and thigh. Forty healthy volunteers will each receive eight tourniquet applications over three days. The goal is to see if placement location affects how quickly and co…

This study compares two surgical methods for fixing a broken hip (femoral neck fracture) using a dynamic hip screw. In one method, the surgeon makes a larger cut to see the bone directly (open reduction); in the other, the bone is aligned without a large cut (closed reduction). T…

This study follows 150 adults undergoing back-of-the-neck and upper spine surgery with metal screws and rods (posterior fixation) for injuries, tumors, or worn-out discs. Researchers track complications, X-ray results, and patient-reported pain over time. The goal is to better un…

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-ap…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study tested a new device that measures blood flow, pressure, and temperature inside the brain, while also draining fluid. It was designed for patients with serious brain injuries who already need standard monitoring. Only one person took part, and the goal was to see if the…

This study tests a program to help people with traumatic brain injury (TBI) who are leaving prison avoid returning to jail. 102 participants will be randomly assigned to either the new program or standard services. The program provides support and teaches coping skills to reduce …

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…

This study aimed to create a program to screen and support families of children under 2 who came to the emergency room with a head injury from neglect or abuse. The goal was to offer brief counseling and connect families with helpful resources. However, the study was withdrawn be…

This study looks at how common mild brain injuries are in Czech soldiers during tough training like parachute jumps and shooting. Researchers will test blood for injury markers and use wearable sensors to measure head impacts. The goal is to find risks and create ways to protect …

This study checks how well 10 existing prediction models can estimate the chance of dying within 30 days after a hip fracture. Researchers will look at data from 3500 patients in the Netherlands, using about 35 health factors. The goal is to find models that are accurate and usef…

This study aimed to test whether high-frequency electrical stimulation could improve bladder control in people with spinal cord injury who already have a special device implanted. Researchers planned to compare high-frequency versus low-frequency stimulation in 5 to 10 participan…

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study is looking at whether changes in RNA found in saliva can help predict how long concussion symptoms will last in children aged 5 to 21. Researchers will collect saliva samples and track symptoms like dizziness and balance problems. The goal is to better understand recov…

This study looks at 600 adults who take blood thinners and have a mild head injury but a normal first brain scan. Researchers want to know how often a delayed brain bleed happens within 24 hours and up to 4 weeks after the injury. They also track risks like blood clots or confusi…

This study was designed to see if a pre-surgery meeting with an occupational therapist helps people with hand injuries or thumb arthritis recover faster and attend their therapy appointments. It planned to include adults needing surgery for a broken wrist, a cut tendon, or thumb …

This study planned to see if a cheap thermal camera that attaches to a smartphone could help doctors figure out how deep a child's second-degree burn is. Deep burns often need skin grafts, but it can take over a week to tell. The idea was that deeper, cooler areas would show up o…