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Could a vacuum dressing slash infection rates after major abdominal surgery?

NCT ID NCT05977816

Disease control Sponsor: Royal College of Surgeons, Ireland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This trial tests whether a negative pressure wound therapy (NPWT) dressing — a special vacuum-sealed bandage — can reduce surgical site infections and improve scar appearance compared to a standard dressing in people who have had a midline laparotomy (a large abdominal incision). About 2,000 adults undergoing this type of surgery will be randomly assigned to receive either the NPWT dressing or a standard dressing after their operation. Researchers will track infection rates for up to six months and also measure quality of life and scar healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Negative Pressure Wound Therapy (NPWT) dressing applied to the wound after surgery
What this could lead to
If it works, this could establish NPWT as a better way to prevent surgical site infections and improve scar healing after abdominal surgery.
What could go wrong
This is a single trial, and results may not apply to all types of abdominal surgery. NPWT dressings can be more expensive and may cause skin irritation in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or older * Patient requires visceral abdominal surgery via a midline laparotomy * Patients who can complete questionnaires Exclusion Criteria: • Patients who are unable to adhere to protocol requirements

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Conditions

The condition(s) this trial relates to.

injury Surgical Wound Surgical Wound Infection Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cosmesis Wound infection Wound surgical

Contacts and locations

Locations

  • Beaumont Hospital

    Dublin, Ireland

  • Letterkenny University Hospital

    Letterkenny, Ireland

  • Mater Misericordiae University Hospital

    Dublin, Ireland

  • Mayo University Hospital

    Castlebar, Ireland

  • Sligo University Hospital

    Sligo, Ireland

  • St James's Hospital

    Dublin, Ireland

  • Tallaght University Hospital

    Dublin, Ireland

  • University Hospital Galway

    Galway, Ireland

  • University Hospital Limerick

    Limerick, Ireland

  • University Hospital Waterford

    Waterford, Ireland

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