Vitamin d and k: the Bone-Boosting duo under the microscope

NCT ID NCT04573946

Ongoing Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how vitamin D and vitamin K interact to affect bone density and fracture risk in older adults. Researchers are analyzing data from over 25,000 participants who took vitamin D and omega-3 supplements or placebos. The goal is to see if people with low vitamin K levels get more bone benefits from vitamin D.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin D3 (cholecalciferol) and omega-3 fatty acids (fish oil)
What this could lead to: If successful, this could clarify whether vitamin K status influences how well vitamin D supplements protect bones, guiding future bone health recommendations.
What could go wrong: This is an observational analysis of an existing trial, not a new treatment test. Results may show no clear link or may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bone fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE DENSITY BONE HEALTH FRACTURES

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.