Which anesthesia is safer for hip fracture surgery? new study aims to find out
NCT ID NCT06952257
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study at Johns Hopkins will enroll 24 older adults having hip fracture surgery with bone cement. It compares general anesthesia to epidural (neuraxial) anesthesia to see which one lowers the risk of bone cement implantation syndrome—a serious complication that can cause breathing problems, low blood pressure, or even cardiac arrest. The study also measures histamine and complement levels to understand why the syndrome happens.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
General anesthesia (intravenous) and neuraxial analgesia (epidural)
What this could lead to
If it works, this could point toward safer anesthesia choices to reduce serious complications during hip fracture surgery.
What could go wrong
This is a very small pilot study with only 24 participants, so results may not apply broadly. It is early-stage research, not a treatment trial.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Dept of Orthopadic Surgery, Johns Hopkins Hospital, JHOC 5221, 601 N. Caroline St.
Baltimore, Maryland, 21287, United States