Can adding albumin improve burn resuscitation?

NCT ID NCT04356859

Completed Disease control Sponsor: American Burn Association Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding albumin (a protein) to standard IV fluids helps adults with severe burns covering at least 25% of their body. 101 participants were randomly assigned to receive either standard fluids alone or standard fluids plus albumin during the first 24-48 hours after injury. The goal was to see if albumin reduces the total fluid needed and improves urine output and other outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Albumin (human)

What this could lead to

If adding albumin works, it could reduce the amount of fluid needed during burn resuscitation, potentially lowering complications like swelling and organ damage.

What could go wrong

This is a small, completed trial with 101 participants, so results may not apply to all burn patients. Albumin is expensive and may not improve survival or other key outcomes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

burn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BURN INJURY

Contacts and locations

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Locations

Arizona Burn Center Valleywise Health

Phoenix, Arizona, 85008, United States
Ascension Via Christi St. Francis

Wichita, Kansas, 67214, United States
Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
Cooperman Barnabas Medical Center

Livingston, New Jersey, 07039, United States
Erie County Medical Center

Buffalo, New York, 14215, United States
Hennepin Healthcare

Minneapolis, Minnesota, 55404, United States
Legacy Health

Portland, Oregon, 97227, United States
Loyola Medicine

Maywood, Illinois, 60153, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Metrohealth Medical Center

Cleveland, Ohio, 44109, United States
Regional Burn Center at Harborview

Seattle, Washington, 98014, United States
Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N3M5, Canada
The University of Tennessee Health Science Center

Memphis, Tennessee, 38163, United States
Torrance Memorial

Torrance, California, 90505, United States
University of Alberta

Edmonton, Alberta, AB T6G 1Z1, Canada
University of California Davis, Regional Burn Center

Sacramento, California, 95817, United States
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45267, United States
University of Florida Health

Gainesville, Florida, 32608, United States
University of Iowa Healthcare

Iowa City, Iowa, 52242, United States
University of Kansas Health System

Kansas City, Kansas, 66160, United States
University of Miami Health System

Miami, Florida, 33136, United States
University of South Florida

Tampa, Florida, 33606, United States
University of Utah Health

Salt Lake City, Utah, 84132, United States
University of Wisconsin Health

Madison, Wisconsin, 53792, United States
West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States
Westchester Medical Center Health Network

Valhalla, New York, 10595, United States